Opendata, web and dolomites

EvoTrap SIGNED

Mechanisms to emerge and replicate the first sequence information of life in geothermal microfluidics of early Earth

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 EvoTrap project word cloud

Explore the words cloud of the EvoTrap project. It provides you a very rough idea of what is the project "EvoTrap" about.

enhanced    selective    capillary    dynamics    taq    molecular    richert    microfluidics    chemistry    forms    strands    chemistries    food    printed    heated    oligonucleotide    accumulated    convection    separated    evolution    base    lc    onset    temperature    illumina    explored    host    emergence    cooperative    mimicking    sequences    tested    drive    hypercycle    sequence    polymerization    200mbar    accumulate    replication    below    boundary    ms    flows    lt    expand    gradients    expertise    boiling    szostak    edc    pressures    gelation    starting    800    fast    deg    select    progressing    water    mechanisms    first    boost    ligation    dna    microfluidic    life    earth    pressure    bind    prebiotic    can    thermal    hydro    ligase    rna    tof    rock    monitor    settings    60    recondensation    fold    explore    equilibrium    biochemistry    mimick    respective    joyce    oligonucleotides    gradient    limited    nbsp    sequencing    trigger    fog    air    small    activated    atp    pores    thermophoresis    modern    creation    heat    autonomous    ribozymes    molecules    primitive    metabolism    lab    reconstruct    interfaces    adp    3d    interesting   

Project "EvoTrap" data sheet

The following table provides information about the project.

Coordinator
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN 

Organization address
address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539
website: www.uni-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙364˙500 €
 EC max contribution 2˙364˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-10-01   to  2023-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN DE (MUENCHEN) coordinator 2˙364˙500.00

Map

 Project objective

Can we reconstruct in the lab the onset of molecular evolution? To trigger the autonomous emergence of the first oligonucleotide sequences, we will explore non-equilibrium boundary conditions and selective mechanisms to host the fast progressing prebiotic replication chemistry of oligonucleotides. We will explore novel water-fog microfluidic settings to boost the replication and selection of the first RNA sequences. The findings aims to enable the creation of primitive life forms in the lab, starting from simple molecules in heated rock pores of early Earth.

Autonomous replication and metabolism. We will expand our thermal gradient expertise to host three replication chemistries. Using 3D printed microfluidics, we will mimick conditions in pores on early Earth. Thermophoresis will select long over short strands, accumulate small food molecules and strands will be separated by thermal convection and novel mechanisms in water-air systems. With respective collaboration partners, we will drive the replication from RNA ribozymes (Joyce), base-by-base RNA replication (Szostak) and EDC activated DNA ligation (Richert) and monitor the results with Illumina sequencing and TOF LC/MS. The ligation will be also explored with Taq ligase since we expect a cooperative replication dynamics with hypercycle-like characteristics. Thermal gradients will drive early metabolism to boost RNA polymerization and select ATP over ADP to drive modern biochemistry.

Sequence selection in low pressure water-air systems. Oligonucleotides bind to water-air interfaces. and can be accumulated 800-fold by heat-driven capillary flows. Based on this, we expect interesting selection effects under microfluidic boiling, fog formation and recondensation dynamics. The settings are tested for sequence selective hydro-gelation of RNA/DNA and enhanced replication chemistry. The temperature of boiling water will be limited below 60°C by using air pressures <200mbar, mimicking very early Earth conditions.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "EVOTRAP" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "EVOTRAP" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

LO-KMOF (2019)

Vapour-deposited metal-organic frameworks as high-performance gap-filling dielectrics for nanoelectronics

Read More  

TRUST (2018)

Truth and Semantics

Read More  

Resonances (2019)

Resonances and Zeta Functions in Smooth Ergodic Theory and Geometry

Read More