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O-POINTED SIGNED

Osteoarthritis patient cohorts in the dish - personalised cellular drug development tools for osteoarthritis precision medicine

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

O-POINTED project word cloud

Explore the words cloud of the O-POINTED project. It provides you a very rough idea of what is the project "O-POINTED" about.

tool expandable companies revenue tools jobs feasibility plus synovium completely pharma representing rates launch benefit clinical variability create estimate osteoarthritis pathophysiology patients populations fastest drug cell consumables cohort million modifying consequently trials worldwide milestone pointed cartilage conventional personalised off commercial disease scaling disability recurring first dimension seek consistently disregard 15 easier phenotypes drugs double lines personalise model customer bone payments underlying fail combined patient cellular minimal business biotech global candidates

Project "O-POINTED" data sheet

The following table provides information about the project.

Coordinator	InSCREENeX GmbH Organization address address: INHOFFENSTRASSE 7 city: BRAUNSCHWEIG postcode: 38124 website: www.inscreenex.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Total cost	71˙429 €
EC max contribution	50˙000 € (70%)
Programme	1. H2020-EU.3. (PRIORITY 'Societal challenges) 2. H2020-EU.2.3. (INDUSTRIAL LEADERSHIP - Innovation In SMEs) 3. H2020-EU.2.1. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies)
Code Call	H2020-SMEInst-2018-2020-1
Funding Scheme	SME-1
Starting year	2019
Duration (year-month-day)	from 2019-06-01 to 2019-11-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	InSCREENeX GmbH InSCREENeX GmbH Organization address address: INHOFFENSTRASSE 7 city: BRAUNSCHWEIG postcode: 38124 website: www.inscreenex.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BRAUNSCHWEIG)	coordinator	50˙000.00

Map

Project objective

Osteoarthritis is the fastest growing cause of disability worldwide. Still, there is currently no drug available that targets the underlying pathophysiology of osteoarthritis. Clinical trials testing disease-modifying drug candidates consistently fail. This is because osteoarthritis is a complex disease and currently used drug development tools completely disregard patient variability. Consequently, such non-personalised drugs fail to reach high enough response rates in highly variable osteoarthritis patient populations. O-POINTED is the first tool to enable pharma and biotech companies to personalise the osteoarthritis drug development process. O-POINTED is a cellular test system based on personalised and expandable cell lines generated from a cohort of more than 50 osteoarthritis patients. It represents osteoarthritis patient variability including all the main disease phenotypes (bone-, cartilage-, synovium-driven). Compared to conventional test systems, it is easier to use and more relevant, with the unique benefit of representing osteoarthritis patient variability. The combined O-POINTED business model includes a double one-off revenue (product plus consumables) and recurring revenue (milestone-based payments). We estimate that O-POINTED will create €2.9 million revenue and 15 new jobs, 3 years after commercial launch. We have a key customer already testing a minimal viable product of O-POINTED and seek Phase 1 support to evaluate the feasibility of scaling up to a European and Global dimension.

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The information about "O-POINTED" are provided by the European Opendata Portal: CORDIS opendata.

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