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BioGraphING SIGNED

Biomolecule Sensing with Graphene-Integrated Nanogaps

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 BioGraphING project word cloud

Explore the words cloud of the BioGraphING project. It provides you a very rough idea of what is the project "BioGraphING" about.

origins    modulations    amino    mechanical    distance    break    electronics    fingerprinting    functions    mcbjs    chemical    biological    atomic    single    cells    acids    molecules    covalent    composition    free    situ    caused    junctions    environment    final    room    offers    nanoscopic    degree    bonding    stacking    exert    function    first    trapping    data    conductance    biophysics    model    graphene    simulations    charge    electronic    arrangement    inside    monitoring    combined    biomolecule    platform    plane    closely    ideal    individual    peptides    transport    pi    monitor    tunnelling    architecture    statistical    spaced    protein    dna    air    superior    molecular    electrodes    temperature    inertness    mcbj    bias    structure    thinness    molecule    liquid    biographing    picometer    species    device    junction    electrode    vacuum    mechanically    bonds    label    fingerprints    modes    gap    sensitive    contact    size    anchoring    stability    discriminate    diseases    sensing    biomolacular    voltage    resolution    quantum   

Project "BioGraphING" data sheet

The following table provides information about the project.

Coordinator
TECHNISCHE UNIVERSITEIT DELFT 

Organization address
address: STEVINWEG 1
city: DELFT
postcode: 2628 CN
website: www.tudelft.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 165˙598 €
 EC max contribution 165˙598 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2020-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITEIT DELFT NL (DELFT) coordinator 165˙598.00

Map

 Project objective

Monitoring the DNA and protein composition of cells is key to understanding most biological processes, including the molecular origins of specific diseases. To this end, the emerging field of molecular electronics offers unique opportunities for label-free single-biomolecule sensing. In particular, tunnelling current modulations caused by trapping an individual molecule in a nanoscopic gap between two electrodes can be used to discriminate species based on their electronic structure. The junction conductance is highly sensitive not only to the structure of the molecule, but also to the gap size, the voltage applied, the bonding arrangement inside the gap and the immediate molecular environment. Mechanically controlled break junctions (MCBJs) that allow the formation of closely-spaced electrodes with picometer resolution, can exert a degree of control over each of these parameters and therefore represent an ideal platform for in-situ studies at single-molecule level.

In BioGraphING, I will develop the first graphene MCBJ, a unique device that will be both a model system for studying charge transport in molecular junctions at room temperature, and a sensing platform for biomolacular fingerprinting. Graphene’s atomic thinness, chemical inertness and strong in-plane bonds will lead to a device architecture with superior mechanical stability and measurement resolution. Given that a robust and reliable contact to single molecules is crucial for high junction conductance, various anchoring modes of the molecules to the graphene electrodes will be investigated (e.g. covalent bonding, π-π stacking). I will monitor the molecular conductance as a function of electrode distance and bias voltage in air, vacuum and in liquid. Combined with quantum transport simulations and statistical data analysis my final goal is to establish molecular fingerprints for amino acids and peptides with specific biological functions, an important challenge in single-molecule biophysics.

 Publications

year authors and title journal last update
List of publications.
2018 Valentin Dubois, Shyamprasad N. Raja, Pascal Gehring, Sabina Caneva, Herre S. J. van der Zant, Frank Niklaus, Göran Stemme
Massively parallel fabrication of crack-defined gold break junctions featuring sub-3 nm gaps for molecular devices
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-05785-2
Nature Communications 9/1 2020-03-23
2018 Sabina Caneva, Pascal Gehring, Víctor M. García-Suárez, Amador García-Fuente, Davide Stefani, Ignacio J. Olavarria-Contreras, Jaime Ferrer, Cees Dekker, Herre S. J. van der Zant
Mechanically controlled quantum interference in graphene break junctions
published pages: 1126-1131, ISSN: 1748-3387, DOI: 10.1038/s41565-018-0258-0
Nature Nanotechnology 13/12 2020-03-23

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The information about "BIOGRAPHING" are provided by the European Opendata Portal: CORDIS opendata.

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