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BioGraphING SIGNED

Biomolecule Sensing with Graphene-Integrated Nanogaps

Total Cost €

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EC-Contrib. €

0

Partnership

0

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 BioGraphING project word cloud

Explore the words cloud of the BioGraphING project. It provides you a very rough idea of what is the project "BioGraphING" about.

dna    label    stability    environment    conductance    fingerprinting    plane    caused    structure    molecule    ideal    device    data    mechanically    sensitive    size    charge    break    free    degree    mechanical    biomolacular    final    air    modes    inertness    trapping    quantum    sensing    bonding    bonds    functions    species    chemical    modulations    liquid    mcbjs    superior    molecular    individual    biomolecule    inside    thinness    distance    statistical    tunnelling    peptides    biographing    exert    junction    fingerprints    discriminate    origins    contact    room    picometer    simulations    composition    junctions    model    biophysics    offers    electrodes    monitor    protein    stacking    voltage    monitoring    electronics    combined    transport    vacuum    nanoscopic    diseases    biological    molecules    electrode    situ    spaced    electronic    atomic    first    architecture    function    bias    gap    graphene    platform    arrangement    temperature    amino    cells    covalent    anchoring    acids    closely    mcbj    pi    single    resolution   

Project "BioGraphING" data sheet

The following table provides information about the project.

Coordinator
TECHNISCHE UNIVERSITEIT DELFT 

Organization address
address: STEVINWEG 1
city: DELFT
postcode: 2628 CN
website: www.tudelft.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 165˙598 €
 EC max contribution 165˙598 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2020-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITEIT DELFT NL (DELFT) coordinator 165˙598.00

Map

 Project objective

Monitoring the DNA and protein composition of cells is key to understanding most biological processes, including the molecular origins of specific diseases. To this end, the emerging field of molecular electronics offers unique opportunities for label-free single-biomolecule sensing. In particular, tunnelling current modulations caused by trapping an individual molecule in a nanoscopic gap between two electrodes can be used to discriminate species based on their electronic structure. The junction conductance is highly sensitive not only to the structure of the molecule, but also to the gap size, the voltage applied, the bonding arrangement inside the gap and the immediate molecular environment. Mechanically controlled break junctions (MCBJs) that allow the formation of closely-spaced electrodes with picometer resolution, can exert a degree of control over each of these parameters and therefore represent an ideal platform for in-situ studies at single-molecule level.

In BioGraphING, I will develop the first graphene MCBJ, a unique device that will be both a model system for studying charge transport in molecular junctions at room temperature, and a sensing platform for biomolacular fingerprinting. Graphene’s atomic thinness, chemical inertness and strong in-plane bonds will lead to a device architecture with superior mechanical stability and measurement resolution. Given that a robust and reliable contact to single molecules is crucial for high junction conductance, various anchoring modes of the molecules to the graphene electrodes will be investigated (e.g. covalent bonding, π-π stacking). I will monitor the molecular conductance as a function of electrode distance and bias voltage in air, vacuum and in liquid. Combined with quantum transport simulations and statistical data analysis my final goal is to establish molecular fingerprints for amino acids and peptides with specific biological functions, an important challenge in single-molecule biophysics.

 Publications

year authors and title journal last update
List of publications.
2018 Valentin Dubois, Shyamprasad N. Raja, Pascal Gehring, Sabina Caneva, Herre S. J. van der Zant, Frank Niklaus, Göran Stemme
Massively parallel fabrication of crack-defined gold break junctions featuring sub-3 nm gaps for molecular devices
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-05785-2
Nature Communications 9/1 2020-03-23
2018 Sabina Caneva, Pascal Gehring, Víctor M. García-Suárez, Amador García-Fuente, Davide Stefani, Ignacio J. Olavarria-Contreras, Jaime Ferrer, Cees Dekker, Herre S. J. van der Zant
Mechanically controlled quantum interference in graphene break junctions
published pages: 1126-1131, ISSN: 1748-3387, DOI: 10.1038/s41565-018-0258-0
Nature Nanotechnology 13/12 2020-03-23

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The information about "BIOGRAPHING" are provided by the European Opendata Portal: CORDIS opendata.

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