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SWIRL SIGNED
Short, weakly interacting RNA ligands for the development of high-concentration monoclonal antibody therapeutics
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0SWIRL project word cloud
Explore the words cloud of the SWIRL project. It provides you a very rough idea of what is the project "SWIRL" about.
commercialize
sequence
protein
elucidated
shield
salts
unmet
molecules
rna
strategies
stage
interacting
blood
aggregation
acids
immunogenic
manner
interaction
formulation
software
fundamental
computational
allergenic
specificity
designing
material
context
amino
solubility
biological
prone
powerful
types
concentration
pharmacological
mabs
involve
independent
cancer
suffer
usage
insufficient
erc
biopharmaceutical
solvent
osmolyte
therapeutic
alteration
efficient
pharmaceutical
simultaneous
swirls
degradable
cardiovascular
autoimmune
rnas
standard
grant
central
designed
suite
principles
excipients
advantage
mab
issue
diseases
physicochemical
proteins
reactivity
unmodified
ligands
weak
therapeutics
starting
interactions
antibodies
exists
disorders
structure
carbohydrates
treatment
monoclonal
surfactants
formulations
Project "SWIRL" data sheet
The following table provides information about the project.
| Coordinator |
UNIVERSITAT WIEN
Organization address contact info |
| Coordinator Country | Austria [AT] |
| Total cost | 150˙000 € |
| EC max contribution | 150˙000 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2018-PoC |
| Funding Scheme | ERC-POC |
| Starting year | 2018 |
| Duration (year-month-day) | from 2018-06-01 to 2019-11-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | UNIVERSITAT WIEN | AT (WIEN) | coordinator | 150˙000.00 |
Map
Project objective
Usage of therapeutic monoclonal antibodies (mAbs) has over the past 20 years become one of the most powerful pharmacological strategies in the treatment of various types of cancer, cardiovascular diseases and autoimmune disorders. Importantly, a central challenge in developing the required high protein concentration formulations of mAb therapeutics is the issue of protein solubility. The current approaches for addressing this challenge typically involve using different osmolyte excipients such as salts, carbohydrates, amino acids or surfactants, but they suffer from various problems including insufficient activity, low specificity, allergenic reactivity and others. Clearly, there exists an unmet need for novel strategies to increase the solubility of mAbs in pharmaceutical formulations in an efficient, cost-effective, target-specific manner. We propose to address this challenge by exploiting one of the central biological interaction partners of proteins, the RNA molecules. Specifically, we will: 1) bring to a product stage a computational software suite for designing short, weakly interacting RNA ligands (SWIRLs) that improve the solubility of aggregation-prone mAb therapeutics in a sequence- specific manner, and 2) commercialize the software for usage in a biopharmaceutical context. The designed SWIRLs increase the solubility of target proteins and shield them from unwanted aggregation through weak, specific interactions and a simultaneous alteration of solvent structure. Moreover, a major advantage of using short, standard unmodified RNAs is that they are non-immunogenic and are degradable in the blood, which makes them a unique material for formulation development. Importantly, the sequence-specific design of SWIRLs for a particular target protein will be based on fundamental physicochemical principles of RNA-protein interactions, recently elucidated by us in the context of our ERC Starting Independent grant project.
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The information about "SWIRL" are provided by the European Opendata Portal: CORDIS opendata.
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No valid XML
lastchecktime (2024-07-16 10:28:08) correctly updated