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vAMRes SIGNED

Vaccines as a remedy for antimicrobial resistant bacterial infections

Total Cost €

EC-Contrib. €

Partnership

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vAMRes project word cloud

Explore the words cloud of the vAMRes project. It provides you a very rough idea of what is the project "vAMRes" about.

bind impossible antigen pneumococcus pipeline governments vaccinology cancer amr fab world bacteria vaccines people un cloned convalescent successful vaccine crystal reverse antibiotics advantage bank vaccinated fragments bactericidal alarm tested men antigens cells usa length screened crystals monoclonal facs technologies structure possibility images assays platform 700 expressed antibodies protection confers co bacterial resistance animal viral perhaps kill g20 2050 passive models causes intoxicate infections full phagocytosis assembly deaths cloning antimicrobial throughput formulations gonococcus million human discovered uk coli conventional opsono captures vivo immunization forecast lower clones difficult digital microscopy health

Project "vAMRes" data sheet

The following table provides information about the project.

Coordinator	FONDAZIONE TOSCANA LIFE SCIENCES Organization address address: VIA FIORENTINA 1 city: SIENA postcode: 53100 website: www.toscanalifesciences.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Total cost	2˙432˙500 €
EC max contribution	2˙432˙500 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2017-ADG
Funding Scheme	ERC-ADG
Starting year	2018
Duration (year-month-day)	from 2018-11-01 to 2023-10-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	FONDAZIONE TOSCANA LIFE SCIENCES FONDAZIONE TOSCANA LIFE SCIENCES Organization address address: VIA FIORENTINA 1 city: SIENA postcode: 53100 website: www.toscanalifesciences.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (SIENA)	coordinator	2˙432˙500.00

Map

Project objective

Antimicrobial Resistance (AMR) is perhaps the most emerging alarm in health. It already causes 700,000 deaths per year and the forecast for 2050 is 10 million deaths, more than cancer today. WHO, UN General Assembly, World Bank, G20, EU, UK and USA governments call for new antibiotics, but the pipeline for new antibiotics is not very promising. Here we propose to use new technologies to develop human monoclonal antibodies and vaccines against three AMR bacteria such as gonococcus, pneumococcus and E.coli. The technology defined as reverse vaccinology 2.0, already successful for viral infections, will be used for bacterial vaccines. Taking advantage of the recent possibility of high throughput cloning of human B cells from convalescent or vaccinated people we aim to find targets difficult or impossible to be discovered using conventional technologies. B cells will be cloned from people convalescent from target infections and from people vaccinated with Men B vaccine which confers some protection against gonococcus. The antibodies produced by the clones will be screened for their ability to bind, intoxicate or kill bacteria using a novel high-throughput microscopy platform that rapidly captures digital images and also with conventional, lower throughput technologies such as bactericidal, opsono-phagocytosis and FACS assays. The selected antibodies, will be expressed as full length and used for passive immunization in animal models and tested for protection in vivo. Finally, those antibodies that will provide the best protection in the above assays, will be used to identify the recognized antigens. Selected antigens will be expressed and tested in vaccine formulations. Fab fragments can be used to make co-crystals with the antigen and determine the crystal structure of the new antigens, for the development of structure-based antigen design. In conclusion we expect to enable development of human monoclonal antibodies and vaccines against AMR.

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The information about "VAMRES" are provided by the European Opendata Portal: CORDIS opendata.