Opendata, web and dolomites

FlyGutHomeostasis SIGNED

Identification of paracrine and systemic signals controlling adult stem cell activity and organ homeostasis

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 FlyGutHomeostasis project word cloud

Explore the words cloud of the FlyGutHomeostasis project. It provides you a very rough idea of what is the project "FlyGutHomeostasis" about.

final    organismal    remarkable    ebs    self    membrane    physiological    systemic    infection    paradigm    fitness    released    environmental    model    enteroendocrine    tissue    energy    screens    secreted    metabolism    communication    coupling    flies    pathological    circuitries    enterocytes    organs    coupled    ee    cells    systematic    feasible    disease    division    health    local    proliferation    gut    independent    prime    epithelial    suited    feeding    due    renewing    transmembrane    physiology    visceral    knockdown    stem    deciphering    proliferative    inputs    saturating    tightly    gi    potentially    steady    tnfr    nutrient    vertebrate    challenged    intestinal    enteroblasts    encoding    renewal    organ    mammals    vms    fly    models    couplings    molecular    muscles    ligand    inter    behavior    capacity    relays    peptides    homeostasis    signals    genes    ageing    reveal    shown    cell    insects    ecs    activation    mammalian    isc    stress    divergence    couple    turnover    proteins    rnais    adult    balance    niche    gastrointestinal    ees    multiple    despite    function   

Project "FlyGutHomeostasis" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 1˙498˙964 €
 EC max contribution 1˙498˙964 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-02-01   to  2024-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 1˙498˙964.00

Map

Leaflet | Map data © OpenStreetMap contributors, CC-BY-SA, Imagery © Mapbox

 Project objective

Due to its remarkable self-renewing capacity, the fly gut has recently become a prime paradigm for studying stem-cell function during adult tissue homeostasis. This capacity for self-renewal relays on the proliferative activity of the intestinal stem cells (ISC), which is tightly coupled with cell loss to maintain intestinal homeostasis. ISC proliferation is controlled by multiple local and systemic signals released from the ISC niche (enterocytes (ECs), enteroendocrine (EE) cells, enteroblasts (EBs), and visceral muscles (VMs)) and non-gastrointestinal (non-GI) organs. Despite the physiological divergence between insects and mammals, studies have shown that flies represent a model that is well suited for studying stem cell physiology during ageing, stress, and infection. As a saturating approach to identify local and systemic signals controlling intestinal homeostasis in steady-state and challenged conditions, RNAis will be used to known down all genes encoding secreted peptides specifically in ECs, EEs, or VMs and all genes encoding transmembrane and membrane-associated proteins in the VMs. The proposed screens should identify novel intra- and inter-organ circuitries allowing communication between the gut and other organs to provide organismal health. In addition, the systematic knockdown of secreted peptides from the ISC niche could identify gut-derived signals that couple changes in environmental inputs, such as nutrient availability, with systemic changes in feeding behavior, energy balance, and metabolism. Since large-scale approaches are not feasible in vertebrate models, the signals identified in the above screens could potentially reveal novel couplings contributing to mammalian GI homeostasis and disease. The final part of the proposed project aims a deciphering the molecular signals coupling epithelial fitness with ligand-independent TNFR activation to control ISC division and epithelial turnover in steady-state, challenged and pathological conditions.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "FLYGUTHOMEOSTASIS" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "FLYGUTHOMEOSTASIS" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

KineTic (2020)

New Reagents for Quantifying the Routing and Kinetics of T-cell Activation

Read More  

INSPIRE (2019)

System-wide discovery and analysis of inositol pyrophosphate signaling networks in plants

Read More  

TechChange (2019)

Technological Change: New Sources, Consequences, and Impact Mitigation

Read More