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FlyGutHomeostasis SIGNED

Identification of paracrine and systemic signals controlling adult stem cell activity and organ homeostasis

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 FlyGutHomeostasis project word cloud

Explore the words cloud of the FlyGutHomeostasis project. It provides you a very rough idea of what is the project "FlyGutHomeostasis" about.

enteroblasts    paradigm    cell    peptides    genes    feasible    systematic    physiological    energy    divergence    encoding    adult    disease    tnfr    released    vms    steady    model    multiple    coupling    feeding    screens    ebs    final    health    circuitries    fitness    isc    ageing    independent    inputs    knockdown    division    rnais    environmental    organismal    behavior    molecular    inter    suited    epithelial    challenged    balance    physiology    local    ligand    infection    insects    flies    vertebrate    signals    visceral    couplings    organs    prime    proliferation    systemic    proteins    proliferative    tightly    potentially    gut    deciphering    tissue    despite    turnover    coupled    ecs    niche    self    transmembrane    mammals    remarkable    activation    shown    muscles    function    relays    pathological    enterocytes    ee    renewal    renewing    enteroendocrine    due    homeostasis    ees    stem    stress    reveal    intestinal    saturating    membrane    mammalian    fly    cells    metabolism    organ    models    couple    gastrointestinal    capacity    gi    communication    secreted    nutrient   

Project "FlyGutHomeostasis" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 1˙498˙964 €
 EC max contribution 1˙498˙964 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-02-01   to  2024-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 1˙498˙964.00

Map

Leaflet | Map data © OpenStreetMap contributors, CC-BY-SA, Imagery © Mapbox

 Project objective

Due to its remarkable self-renewing capacity, the fly gut has recently become a prime paradigm for studying stem-cell function during adult tissue homeostasis. This capacity for self-renewal relays on the proliferative activity of the intestinal stem cells (ISC), which is tightly coupled with cell loss to maintain intestinal homeostasis. ISC proliferation is controlled by multiple local and systemic signals released from the ISC niche (enterocytes (ECs), enteroendocrine (EE) cells, enteroblasts (EBs), and visceral muscles (VMs)) and non-gastrointestinal (non-GI) organs. Despite the physiological divergence between insects and mammals, studies have shown that flies represent a model that is well suited for studying stem cell physiology during ageing, stress, and infection. As a saturating approach to identify local and systemic signals controlling intestinal homeostasis in steady-state and challenged conditions, RNAis will be used to known down all genes encoding secreted peptides specifically in ECs, EEs, or VMs and all genes encoding transmembrane and membrane-associated proteins in the VMs. The proposed screens should identify novel intra- and inter-organ circuitries allowing communication between the gut and other organs to provide organismal health. In addition, the systematic knockdown of secreted peptides from the ISC niche could identify gut-derived signals that couple changes in environmental inputs, such as nutrient availability, with systemic changes in feeding behavior, energy balance, and metabolism. Since large-scale approaches are not feasible in vertebrate models, the signals identified in the above screens could potentially reveal novel couplings contributing to mammalian GI homeostasis and disease. The final part of the proposed project aims a deciphering the molecular signals coupling epithelial fitness with ligand-independent TNFR activation to control ISC division and epithelial turnover in steady-state, challenged and pathological conditions.

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The information about "FLYGUTHOMEOSTASIS" are provided by the European Opendata Portal: CORDIS opendata.

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