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HUMAN TEXTILES SIGNED

Human, Woven, Tissue-Engineered Blood Vessels (TEBV) Exclusively from Cell-Assembled Extracellular Matrix (CAM).

Total Cost €

EC-Contrib. €

Partnership

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HUMAN TEXTILES project word cloud

Explore the words cloud of the HUMAN TEXTILES project. It provides you a very rough idea of what is the project "HUMAN TEXTILES" about.

time profiles 1 rolling subcutaneous fibroblasts innate limb engineering limitations assembly yarns scaffold coronary 2 generation rolled yarn human saving peripheral dialysis recipient performance data clinical reduce mechanical types matrix reactivity device small weaving 3 conduits normal implants biological sheets diameter vivo perform tissue initial versatile life vessel tunable characterizing grafts completely woven living patient immune blood rats animal nude quantifying bypass variety limited ready textiles costly consuming tebvs population screening organs remodeling 4 organization tebv poorly vitro synthetic setting extracellular cell fold allogeneic lift textile vascular cam assembled clinically shown adult composition engineered

Project "HUMAN TEXTILES" data sheet

The following table provides information about the project.

Coordinator	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Organization address address: RUE DE TOLBIAC 101 city: PARIS postcode: 75654 website: www.inserm.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Total cost	2˙491˙543 €
EC max contribution	2˙491˙543 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2017-ADG
Funding Scheme	ERC-ADG
Starting year	2018
Duration (year-month-day)	from 2018-11-01 to 2023-10-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Organization address address: RUE DE TOLBIAC 101 city: PARIS postcode: 75654 website: www.inserm.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	coordinator	2˙491˙543.00

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Project objective

'Synthetic vascular grafts perform very poorly in small diameter applications (coronary/peripheral bypass) and for dialysis access. Better vascular conduits for these applications would be life and limb-saving for a very large patient population. A biological, human, tissue-engineered blood vessel (TEBV) may be such a device. We have developed a method to produce robust sheets of cell-assembled extracellular matrix (CAM) from normal, adult, human fibroblasts in vitro. These have been rolled into TEBV and shown promising clinical results. However, this initial rolling approach is very costly, time consuming and has limited mechanical design potential. Here, we propose a new textile-based assembly method that can lift all these limitations.

Task#1 will aim at processing CAM sheets into various types of yarns (human and large animal) and characterizing composition, organization, and mechanical properties. Task#2 will aim at quantifying the in vivo remodeling of the various yarns in nude rats (human yarn) and in an allogeneic recipient (large animal) as subcutaneous implants. This screening process will identify yarns with the best biological response and mechanical profiles. Task#3 will aim at weaving human and animal, non-living, TEBVs with clinically relevant biological and mechanical properties. Task#4 will evaluate the long-term (1 year) performance of the animal TEBV in an allogeneic setting.

This study will provide: 1) in-depth understanding of the immune reactivity of this CAM, both from the innate and specific immune system. 2) long-term performance data of a woven, CAM-based, TEBV in an allogeneic setting (animal). 3) a human woven TEBV with clinically relevant mechanical properties ready for in vivo testing. This “next generation” assembly method will reduce TEBV production time/cost 3-fold and represents a more versatile, reliable and highly tunable approach. HUMAN TEXTILES will provide a COMPLETELY NEW TYPE OF SCAFFOLD for engineering a variety of organs.'

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The information about "HUMAN TEXTILES" are provided by the European Opendata Portal: CORDIS opendata.