HUMAN TEXTILES SIGNED
Human, Woven, Tissue-Engineered Blood Vessels (TEBV) Exclusively from Cell-Assembled Extracellular Matrix (CAM).
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0HUMAN TEXTILES project word cloud
Explore the words cloud of the HUMAN TEXTILES project. It provides you a very rough idea of what is the project "HUMAN TEXTILES" about.
Project "HUMAN TEXTILES" data sheet
The following table provides information about the project.
| Coordinator |
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Organization address contact info |
| Coordinator Country | France [FR] |
| Total cost | 2˙491˙543 € |
| EC max contribution | 2˙491˙543 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2017-ADG |
| Funding Scheme | ERC-ADG |
| Starting year | 2018 |
| Duration (year-month-day) | from 2018-11-01 to 2023-10-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE | FR (PARIS) | coordinator | 2˙491˙543.00 |
Map
Project objective
'Synthetic vascular grafts perform very poorly in small diameter applications (coronary/peripheral bypass) and for dialysis access. Better vascular conduits for these applications would be life and limb-saving for a very large patient population. A biological, human, tissue-engineered blood vessel (TEBV) may be such a device. We have developed a method to produce robust sheets of cell-assembled extracellular matrix (CAM) from normal, adult, human fibroblasts in vitro. These have been rolled into TEBV and shown promising clinical results. However, this initial rolling approach is very costly, time consuming and has limited mechanical design potential. Here, we propose a new textile-based assembly method that can lift all these limitations.
Task#1 will aim at processing CAM sheets into various types of yarns (human and large animal) and characterizing composition, organization, and mechanical properties. Task#2 will aim at quantifying the in vivo remodeling of the various yarns in nude rats (human yarn) and in an allogeneic recipient (large animal) as subcutaneous implants. This screening process will identify yarns with the best biological response and mechanical profiles. Task#3 will aim at weaving human and animal, non-living, TEBVs with clinically relevant biological and mechanical properties. Task#4 will evaluate the long-term (1 year) performance of the animal TEBV in an allogeneic setting.
This study will provide: 1) in-depth understanding of the immune reactivity of this CAM, both from the innate and specific immune system. 2) long-term performance data of a woven, CAM-based, TEBV in an allogeneic setting (animal). 3) a human woven TEBV with clinically relevant mechanical properties ready for in vivo testing. This “next generation” assembly method will reduce TEBV production time/cost 3-fold and represents a more versatile, reliable and highly tunable approach. HUMAN TEXTILES will provide a COMPLETELY NEW TYPE OF SCAFFOLD for engineering a variety of organs.'
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "HUMAN TEXTILES" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "HUMAN TEXTILES" are provided by the European Opendata Portal: CORDIS opendata.