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LIGHTPORT SIGNED

From light-stimulated anion receptors to transmembrane carriers and pumps

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 LIGHTPORT project word cloud

Explore the words cloud of the LIGHTPORT project. It provides you a very rough idea of what is the project "LIGHTPORT" about.

alternative    solar    concentration    dynamically    receptors    toward    death    synthetic    induce    cancer    actuated    wp2    directed    bacterial    pharmacological    last    membrane    mechanically    anions    transporters    visible    convert    whereas    view    biological    anionic    structures    decade    environment    constructing    function    platforms    cell    store    diseases    pumping    endeavour    phospholipid    wp3    utilizing    progress    regulate    gradients    membranes    behavior    static    contemporary    localized    photoswitchable    energy    carriers    treatment    dual    route    interlocked    divided    light    transport    prepared    integrate    pumps    stimuli    channel    completely    photoswitches    triggered    despite    transmembrane    binding    mostly    gated    active    artificial    proteins    structurally    rigid    natural    interdisciplinary    deals    packages    hosts    modulated    passive    gradient    mediated    chemists    mimic    bilayers    wp1    anion    dysregulation    responsive   

Project "LIGHTPORT" data sheet

The following table provides information about the project.

Coordinator
RIJKSUNIVERSITEIT GRONINGEN 

Organization address
address: Broerstraat 5
city: GRONINGEN
postcode: 9712CP
website: www.rug.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 1˙499˙461 €
 EC max contribution 1˙499˙461 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-03-01   to  2024-02-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    RIJKSUNIVERSITEIT GRONINGEN NL (GRONINGEN) coordinator 1˙499˙461.00

Map

 Project objective

The transport of anions across the cell membrane, which is mediated by transport proteins, is essential to many important biological processes. Dysregulation of this transport has been associated to various diseases and therefore, chemists endeavour to develop artificial receptors that mimic the function of natural transporters. Despite much progress over the last decade, the current artificial systems are mostly static, while proteins are able to change their activity dynamically in response to stimuli in the environment. To integrate such stimuli-controlled behavior in synthetic systems is a key contemporary challenge. In view of this, the goal of the proposed research program is to develop anion receptors in which the binding properties can be effectively modulated by light and to apply these receptors as transmembrane carriers and pumps, in order to regulate passive transport (i.e. down a concentration gradient) and to induce active transport (i.e. against a concentration gradient). This interdisciplinary program is divided into three work packages: WP1 aims at the development of structurally rigid and visible-light-actuated photoswitches and their use as platforms for constructing anion receptors; WP2 deals with the development of mechanically interlocked structures as photoswitchable anionic hosts; WP3 is directed at utilizing these receptors for light-gated transport and light-driven pumping of anions across phospholipid bilayers, whereas also an alternative dual-responsive anion channel will be prepared. Eventually, it is expected that this work will open a new route toward light-based localized pharmacological treatment, e.g. via light-triggered cancer or bacterial cell death. Furthermore, active transport systems, that are able to build up and maintain concentration gradients across membranes, could provide a completely new view on how to convert and store light (solar) energy.

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The information about "LIGHTPORT" are provided by the European Opendata Portal: CORDIS opendata.

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