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ENDpoiNTs SIGNED

Novel Testing Strategies for Endocrine Disruptors in the Context of Developmental NeuroToxicity

Total Cost €

EC-Contrib. €

Partnership

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ENDpoiNTs project word cloud

Explore the words cloud of the ENDpoiNTs project. It provides you a very rough idea of what is the project "ENDpoiNTs" about.

exposure generate neurodevelopment independent interaction combination causal biostatistics strategies calls disruption guidelines molecular differences tools behavioural edcs learning technologies vitro hazard innovative markers outcomes rapid urgent endocrine predictive associations basic silico human lack species designs relevance insights experimental endpoints chemical epidemiological linking societal assays supports linked dnt international impaired ed validate screening combining data frameworks developmental continuous expertise machine risk stakeholders integrating links clear communities edc animal sex biomonitoring neurotoxicity regulatory vivo scientific close omics meet disrupting toxicology correlative

Project "ENDpoiNTs" data sheet

The following table provides information about the project.

Coordinator	UPPSALA UNIVERSITET Organization address address: VON KRAEMERS ALLE 4 city: UPPSALA postcode: 751 05 website: www.uu.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Sweden [SE]
Total cost	7˙578˙990 €
EC max contribution	6˙889˙033 € (91%)
Programme	1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
Code Call	H2020-SC1-2018-Single-Stage-RTD
Funding Scheme	RIA
Starting year	2019
Duration (year-month-day)	from 2019-01-01 to 2023-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UPPSALA UNIVERSITET UPPSALA UNIVERSITET Organization address address: VON KRAEMERS ALLE 4 city: UPPSALA postcode: 751 05 website: www.uu.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (UPPSALA)	coordinator	945˙322.00
2	INSTITUT FUR UMWELTMEDIZINISCHE FORSCHUNG AN DER HEINRICH-HEINE-UNIVERSITAT DUSSELDORF GMBH INSTITUT FUR UMWELTMEDIZINISCHE FORSCHUNG AN DER HEINRICH-HEINE-UNIVERSITAT DUSSELDORF GMBH Organization address address: AUF M HENNEKAMP 50 city: DUESSELDORF postcode: 40225 website: www.iuf.uni-duesseldorf.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (DUESSELDORF)	participant	1˙071˙300.00
3	STICHTING VU STICHTING VU Organization address address: DE BOELELAAN 1105 city: AMSTERDAM postcode: 1081 HV website: www.vu.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	participant	926˙776.00
4	UNIVERSITA DEGLI STUDI DI MILANO UNIVERSITA DEGLI STUDI DI MILANO Organization address address: Via Festa Del Perdono 7 city: MILANO postcode: 20122 website: www.unimi.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	participant	898˙517.00
5	UNIVERSITEIT UTRECHT UNIVERSITEIT UTRECHT Organization address address: HEIDELBERGLAAN 8 city: UTRECHT postcode: 3584 CS website: www.uu.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (UTRECHT)	participant	632˙133.00
6	GREEN TOX GMBH GREEN TOX GMBH Organization address address: LANGACKERSTRASSE 49 city: ZURICH postcode: 8057 website: www.greentox.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (ZURICH)	participant	411˙890.00
7	KAROLINSKA INSTITUTET KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	participant	334˙856.00
8	INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE Organization address address: BOULEVARD DE L'HOPITAL 47 city: PARIS postcode: 75013 website: http://icm-institute.org/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	315˙525.00
9	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Organization address address: RUE MICHEL ANGE 3 city: PARIS postcode: 75794 website: www.cnrs.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	315˙437.00
10	UNIVERSITAT KONSTANZ UNIVERSITAT KONSTANZ Organization address address: UNIVERSITATSSTRASSE 10 city: KONSTANZ postcode: 78464 website: www.uni-konstanz.de/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (KONSTANZ)	participant	300˙000.00
11	UNIVERSIDAD COMPLUTENSE DE MADRID UNIVERSIDAD COMPLUTENSE DE MADRID Organization address address: AVENIDA DE SENECA 2 city: MADRID postcode: 28040 website: http://www.ucm.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	participant	199˙375.00
12	UMEA UNIVERSITET UMEA UNIVERSITET Organization address address: UNIVERSITETOMRADET city: UMEA postcode: 901 87 website: www.umu.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (UMEA)	participant	198˙750.00
13	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI Organization address address: ONE GUSTAVE L LEVY PLACE BOX 1075 city: NEW YORK postcode: 10029 6574 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (NEW YORK)	participant	124˙972.00
14	BRUNEL UNIVERSITY LONDON BRUNEL UNIVERSITY LONDON Organization address address: KINGSTON LANE city: UXBRIDGE postcode: UB8 3PH website: www.brunel.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (UXBRIDGE)	participant	112˙500.00
15	KARLSTADS UNIVERSITET KARLSTADS UNIVERSITET Organization address address: UNIVERSITETSGATAN 2 city: KARLSTAD postcode: 651 88 website: www.kau.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (KARLSTAD)	participant	101˙677.00
16	MURDOCH CHILDRENS RESEARCH INSTITUTE MURDOCH CHILDRENS RESEARCH INSTITUTE Organization address address: FLEMINGTON ROAD RCH city: PARKVILLE postcode: 3052 website: www.mcri.edu.au contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AU (PARKVILLE)	participant	0.00
17	THE UNIVERSITY OF QUEENSLAND THE UNIVERSITY OF QUEENSLAND Organization address address: ST LUCIA city: BRISBANE postcode: 4072 website: http://www.uq.edu.au contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AU (BRISBANE)	participant	0.00
18	UNIVERSITY OF MELBOURNE UNIVERSITY OF MELBOURNE Organization address address: PARKVILLEOFFICE OF THE VICE CHANCELLOR city: MELBOURNE postcode: 3010 website: www.unimelb.edu.au contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AU (MELBOURNE)	participant	0.00

Map

Project objective

Clear evidence supports associations between endocrine disrupting chemical (EDC) exposure and impaired neurodevelopment. Yet, current hazard assessment of EDCs does not address developmental neurotoxicity. This is due to lack of scientific knowledge on how endocrine disruption is linked to developmental neurotoxicity (DNT). Thus there is an urgent need for novel testing and screening tools to address ED-induced DNT, based on new scientific knowledge. This calls for rapid advances in basic research as well as in the development of screening and testing tools close to the end-users. ENDpoiNTs will address this need by i) integrating advanced expertise in the EDC and DNT fields, two so far rather independent toxicology communities, and ii) continuous interaction with European and international key stakeholders. By combining state-of-the-art in silico and in vitro tools, innovative experimental designs and technologies, and advanced biostatistics on human epidemiological and biomonitoring data, ENDpoiNTs will 1) Generate the necessary scientific insights on the correlative and causal links between endocrine disruption and DNT; 2) Develop predictive in silico tools for chemical screening using machine learning and combination of evidence; 3) Develop and validate in vitro tools for chemical screening and testing that address sex- and species differences; 4) Develop novel molecular endpoints for existing animal-based test guidelines by integrating in vitro, in vivo, and human omics data with behavioural outcomes; 5) Ensure human relevance by linking experimental and epidemiological evidence; 6) Develop an integrated testing approach based on the developed in silico, in vitro, and in vivo assays and molecular markers; 7) Ensure regulatory relevance by developing strategies for implementation of these tools and endpoints into regulatory frameworks. In this way, ENDpoiNTs will meet the scientific, regulatory, and societal needs for improved hazard and risk assessment of EDCs

Deliverables

List of deliverables.
Launch of Website, logo and flyer	Websites, patent fillings, videos etc.	2020-04-21 01:15:02
1st animation	Websites, patent fillings, videos etc.	2020-04-21 01:15:02
Set of test compounds	Documents, reports	2020-04-21 01:15:02

Take a look to the deliverables list in detail: detailed list of ENDpoiNTs deliverables.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ENDPOINTS" project.

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Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

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The information about "ENDPOINTS" are provided by the European Opendata Portal: CORDIS opendata.