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GIOTTO SIGNED

Active aGeIng and Osteoporosis: The next challenge for smarT nanobiOmaterials and 3D technologies

Total Cost €

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EC-Contrib. €

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Partnership

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GIOTTO project word cloud

Explore the words cloud of the GIOTTO project. It provides you a very rough idea of what is the project "GIOTTO" about.

activation systemic oscillating confined fractures regeneration cell align mechanotransduction appropriate measurable anatomy platform boost meet anti injectable people men cement materials osteoporotic treatment deal prevalence age additive recruitment functionalised chemical activate reducing bioresorbable postmenopausal molecules serious validating giotto remote gather decision share solutions biological patient fibrous function dependent nanofunctionalisation collate fifth cues degenerative stabilise risk external women die chain device release suffering types nanobiomaterials tool internet ultimately specificity bone pelvic nanoparticles predominantly technologies drugs designing active healing radiopaque fracture fixated elderly stimulating clinical smart things inputs tissue match 3d vertebral magnetic small effectiveness systematic software treat manufacture graded parallel temporalised service personalisation osteoporosis data manufacturing disorder screws stimulate half scaffold

Project "GIOTTO" data sheet

The following table provides information about the project.

Coordinator	POLITECNICO DI TORINO Organization address address: CORSO DUCA DEGLI ABRUZZI 24 city: TORINO postcode: 10129 website: www.polito.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Total cost	5˙660˙096 €
EC max contribution	5˙660˙096 € (100%)
Programme	1. H2020-EU.2.1.3. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Advanced materials) 2. H2020-EU.2.1.2. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies)
Code Call	H2020-NMBP-TR-IND-2018
Funding Scheme	RIA
Starting year	2019
Duration (year-month-day)	from 2019-01-01 to 2023-02-28

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	POLITECNICO DI TORINO POLITECNICO DI TORINO Organization address address: CORSO DUCA DEGLI ABRUZZI 24 city: TORINO postcode: 10129 website: www.polito.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (TORINO)	coordinator	920˙750.00
2	BIOMECH INNOVATIONS AG BIOMECH INNOVATIONS AG Organization address address: AARBERGSTRASSE 5 city: NIDAU postcode: 2560 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (NIDAU)	participant	622˙067.00
3	NOVAICOS SRLS NOVAICOS SRLS Organization address address: VIA AMICO CANOBIO 4/6 city: NOVARA (NO) postcode: 28100 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (NOVARA (NO))	participant	550˙312.00
4	UNIVERSITEIT MAASTRICHT UNIVERSITEIT MAASTRICHT Organization address address: Minderbroedersberg 4-6 city: MAASTRICHT postcode: 6200 MD website: http://www.maastrichtuniversity.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (MAASTRICHT)	participant	392˙490.00
5	IDRYMA TECHNOLOGIAS KAI EREVNAS IDRYMA TECHNOLOGIAS KAI EREVNAS Organization address address: N PLASTIRA STR 100 city: IRAKLEIO postcode: 70013 website: www.forth.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (IRAKLEIO)	participant	375˙000.00
6	UNIVERSITY OF NEWCASTLE UPON TYNE UNIVERSITY OF NEWCASTLE UPON TYNE Organization address address: KINGS GATE city: NEWCASTLE UPON TYNE postcode: NE1 7RU website: http://www.ncl.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (NEWCASTLE UPON TYNE)	participant	362˙445.00
7	DUBLIN CITY UNIVERSITY DUBLIN CITY UNIVERSITY Organization address address: Glasnevin city: DUBLIN postcode: 9 website: www.dcu.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (DUBLIN)	participant	355˙608.00
8	UNIVERSITA DI PISA UNIVERSITA DI PISA Organization address address: LUNGARNO PACINOTTI 43/44 city: PISA postcode: 56126 website: www.unipi.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (PISA)	participant	332˙000.00
9	UNIVERSIDAD COMPLUTENSE DE MADRID UNIVERSIDAD COMPLUTENSE DE MADRID Organization address address: AVENIDA DE SENECA 2 city: MADRID postcode: 28040 website: http://www.ucm.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	participant	326˙047.00
10	BEWARRANT BEWARRANT Organization address address: AVENUE HENRI JASPAR 113 city: BRUXELLES postcode: 1060 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (BRUXELLES)	participant	324˙625.00
11	CELLINK AB CELLINK AB Organization address address: ARVID WALLGRENS BACKE 20 city: GOTEBORG postcode: 413 46 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (GOTEBORG)	participant	300˙000.00
12	YODIWO ANONYMI ETAIREIA SCHEDIASISOLOKLIROMENON KYKLOMATON YODIWO ANONYMI ETAIREIA SCHEDIASISOLOKLIROMENON KYKLOMATON Organization address address: E O ANO KATO KASTRITSIOU 4 city: RIO PATRAS postcode: 26504 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (RIO PATRAS)	participant	297˙750.00
13	TECNOLOGIA NAVARRA DE NANOPRODUCTOS SL TECNOLOGIA NAVARRA DE NANOPRODUCTOS SL Organization address address: AREA INDUSTRIAL PERGUITA C/A 1 city: LOS ARCOS postcode: 31210 website: http://www.tecnan-nanomat.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (LOS ARCOS)	participant	263˙500.00
14	FLUIDINOVA SA FLUIDINOVA SA Organization address address: RUA ENGENHEIRO FREDERICO ULRICH 2650 TECMAIA PARQUE DE CIENCIA E TECNOLOGIA DA MAIA city: MAIA postcode: 4470 605 website: www.fluidinova.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (MAIA)	participant	237˙500.00

Map

Project objective

Osteoporosis is a systemic, degenerative disorder, predominantly affecting postmenopausal women (1 out of 3) but also men at an advanced age (1 out of 5) and it increases the prevalence of fracture risk. One fifth of people suffering an osteoporotic fracture will die within a year and half will become dependent. Appropriate anti-osteoporotic drugs are available but have serious side effects and they do not promote fracture healing. The concept behind GIOTTO is to develop a platform of technologies and materials for the treatment of different types of osteoporotic fractures, designing, manufacturing and validating three different solutions: 1) 3D graded scaffold, which can be fixated with screws, to treat long bone fractures 2) Fibrous scaffold to deal with small, not confined pelvic fractures; 3) Radiopaque, bioresorbable, injectable cement to stabilise vertebral fractures. The three devices will share smart nanobiomaterials that release chemical and biological cues to stimulate bone regeneration while reducing bone loss. Nanofunctionalisation and the smart, temporalised release of active molecules will allow for the systematic cell recruitment and activation needed to face the challenges of stimulating bone tissue regeneration in the elderly. The use of additive manufacturing technologies will enable device personalisation to match and better align with the patient’s anatomy and fracture type. A further boost to meet patient specificity and needs, will be provided through the use of functionalised magnetic nanoparticles in order to provide, via the application of an external oscillating magnetic field, a remote tool to activate mechanotransduction. In parallel, an Internet of Things platform will be developed to gather and collate measurable data inputs about device effectiveness and to provide decision support software as a service to improve the design, manufacture and clinical function of the proposed devices, ultimately managing the overall value chain.

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