MIAMi SIGNED
Refactoring monoterpenoid indole alkaloid production in microbial cell factories
Total Cost €
0EC-Contrib. €
0Partnership
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0MIAMi project word cloud
Explore the words cloud of the MIAMi project. It provides you a very rough idea of what is the project "MIAMi" about.
Project "MIAMi" data sheet
The following table provides information about the project.
| Coordinator |
DANMARKS TEKNISKE UNIVERSITET
Organization address contact info |
| Coordinator Country | Denmark [DK] |
| Total cost | 6˙648˙301 € |
| EC max contribution | 6˙648˙301 € (100%) |
| Programme |
1. H2020-EU.2.1.4. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Biotechnology) |
| Code Call | H2020-NMBP-BIO-2018-two-stage |
| Funding Scheme | RIA |
| Starting year | 2019 |
| Duration (year-month-day) | from 2019-01-01 to 2022-12-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | DANMARKS TEKNISKE UNIVERSITET | DK (KGS LYNGBY) | coordinator | 1˙438˙313.00 |
| 2 | MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV | DE (MUENCHEN) | participant | 1˙511˙371.00 |
| 3 | UNIVERSITE DE TOURS | FR (TOURS) | participant | 1˙165˙125.00 |
| 4 | FUTURE GENOMICS TECHNOLOGIES BV | NL (LEIDEN) | participant | 853˙750.00 |
| 5 | EXPLORA SRL | IT (ROMA) | participant | 719˙250.00 |
| 6 | AXYNTIS | FR (PARIS) | participant | 619˙375.00 |
| 7 | KOBENHAVNS UNIVERSITET | DK (KOBENHAVN) | participant | 341˙116.00 |
| 8 | JOHN INNES CENTRE | UK (NORWICH) | participant | 0.00 |
Map
Project objective
Plants produce some of the most potent human therapeutics and have been used for millennia to treat illnesses. The monoterpenoid indole alkaloids (MIAs) are plant secondary metabolites that show a remarkable structural diversity and pharmaceutically valuable biological activities with more than 2,000 MIAs derived from the common precursor strictosidine. However, because most MIA chemicals do not have their biosynthetic pathways elucidated and MIA-producing plants are not genetically trackable, MIAs are under-represented in recently introduced medicines. In the consortium for Refactoring of Monoterpenoid Indole Alkaloids in Microbial Cell Factories (MIAMi) our main objective is to develop sustainable microbial production of new human therapies for the benefit of the European biotech industry, human health, and the environment. To do so, MIAMi will i) develop a new approach for MIA biosynthetic pathway discovery in plants founded on supervised learning algorithms based on omics data sampled from > 20 MIA producing plants, ii) contribute to standardisation of bioengineering by development of SOPs for characterisation of > 100 DNA elements for control of gene expression, protein interactions, and sub-cellular localisation, iii) build a public parts repository and Bio-CAD for forward engineering of compartmentalised biosynthetic pathway designs in yeast, and iv) apply automated genome engineering to prototype > 1,000 new-to-nature MIA biosynthetic pathway designs in order to identify robust designs for scale-up microbial MIA production processes, and evaluate the environmental benefits and risks compared to existing value chains. The excellent, interdisciplinary and inter-sectorial consortium will showcase the use of the new approaches and standardised data inventory to produce both commercially available and new-to-market MIAs rauwolscine, tabersonine and alstonine in yeast, and finally test their bioactivity as new cancer and psychosis treatment drug leads.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2020 |
Thomas Dugé de Bernonville, Nicolas Papon, Marc Clastre, Sarah E. O’Connor, Vincent Courdavault Identifying Missing Biosynthesis Enzymes of Plant Natural Products published pages: , ISSN: 0165-6147, DOI: 10.1016/j.tips.2019.12.006 |
Trends in Pharmacological Sciences | 2020-02-20 |
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