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GLU-IMAGE SIGNED

Glutamate dynamics during visual stimulation and ketamine challenge in the human brain

Total Cost €

0

EC-Contrib. €

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Partnership

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 GLU-IMAGE project word cloud

Explore the words cloud of the GLU-IMAGE project. It provides you a very rough idea of what is the project "GLU-IMAGE" about.

functional    mrsi    invasive    cortex    proton    demands    therapy    mrs    utilized    ketamine    standard    critical    improvements    vascular    bold    ute    concentrations    treatment    glucose    coverage    imaging    glutamate    resolution    acc    vivo    energetic    dynamic    conventional    glu    trd    receptor    infusion    overcomes    slice    measured    healthy    potent    therapies    baseline    while    ground    mechanism    tomography    clinical    exact    pharmacologically    action    ultra    subjects    previously    voxels    improvement    spatial    monitor    vienna    administration    direct    medical    signals    antagonist    activated    positron    boost    patients    monitoring    sensitivity    showed    university    urgently    emission    elevated    limited    disorder    image    time    aspartate    correction    blood    applicability    gold    methyl    insula    breaking    missing    pioneering    single    dependent    cingulate    selectively    reproducibly    oxygenation    depressive    understand    glutamatergic    minute    resistant    group    reliably    dynamics    motion    confirmed    human    suggesting    clarify    muw    sv    unclear    voxel    metabolism    accelerated    echo    thalamus    optimal    metabolic    brain    anterior   

Project "GLU-IMAGE" data sheet

The following table provides information about the project.

Coordinator
MEDIZINISCHE UNIVERSITAET WIEN 

Organization address
address: SPITALGASSE 23
city: WIEN
postcode: 1090
website: www.meduniwien.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Total cost 186˙167 €
 EC max contribution 186˙167 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-07-01   to  2021-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MEDIZINISCHE UNIVERSITAET WIEN AT (WIEN) coordinator 186˙167.00

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 Project objective

While clinical experience confirmed ketamine, a glutamate (Glu) N-methyl-D-aspartate receptor antagonist, as a potent therapy of treatment-resistant major depressive disorder (TRD), the exact mechanism of ketamine’s action in the brain is unclear. Thus, a method to reliably and reproducibly monitor minute changes in Glu metabolism in the human brain is urgently needed to understand ketamine dynamics in vivo. So far, the pioneering work at the Medical University Vienna (MUW) showed ketamine-induced increase of vascular and metabolic responses measured as blood oxygenation level dependent (BOLD) signals in healthy subjects in thalamus, insula and anterior cingulate cortex (ACC), while others observed elevated glucose uptake using positron emission tomography, suggesting higher energetic demands and Glu response after ketamine infusion. Yet, a reliable and non-invasive method for direct monitoring of pharmacologically-induced dynamic Glu changes is still missing. Our group at MUW has recently developed a novel ground-breaking accelerated method for ultra-short echo time MRS imaging (UTE-MRSI) providing optimal Glu measures with critical sensitivity improvements compared to conventional proton single-voxel MRS (SV-MRS) and previously utilized MRSI approaches. Our method allows monitoring of Glu responses selectively in activated voxels and overcomes low spatial resolution, and limited coverage of SV-MRS that is the current gold standard for measurement of Glu concentrations and its dynamic changes in vivo (functional SV-MRS). The further improvement of UTE-MRSI by the implementation of the novel real-time motion correction will boost its applicability in clinical human studies. Thus, our UTE-MRSI will offer image-based multi-slice measurements of baseline Glu concentrations and its responses to ketamine administration with the potential to clarify ketamine’s mechanism of action in patients with TRD, and will allow monitoring of other novel glutamatergic therapies.

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The information about "GLU-IMAGE" are provided by the European Opendata Portal: CORDIS opendata.

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