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GLU-IMAGE SIGNED

Glutamate dynamics during visual stimulation and ketamine challenge in the human brain

Total Cost €

0

EC-Contrib. €

0

Partnership

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 GLU-IMAGE project word cloud

Explore the words cloud of the GLU-IMAGE project. It provides you a very rough idea of what is the project "GLU-IMAGE" about.

optimal    glutamate    activated    echo    standard    clinical    demands    elevated    mrsi    single    tomography    pioneering    slice    emission    monitor    therapies    time    cingulate    positron    overcomes    measured    glutamatergic    conventional    motion    missing    while    improvement    spatial    vienna    healthy    monitoring    boost    previously    glu    patients    gold    oxygenation    ultra    trd    coverage    functional    energetic    acc    medical    pharmacologically    confirmed    concentrations    utilized    reproducibly    administration    showed    mechanism    clarify    aspartate    treatment    metabolism    ground    human    metabolic    sensitivity    receptor    critical    resolution    group    therapy    limited    glucose    brain    reliably    urgently    invasive    selectively    mrs    muw    improvements    minute    action    correction    blood    direct    image    disorder    ute    breaking    methyl    insula    potent    imaging    dependent    university    proton    cortex    signals    resistant    thalamus    bold    vascular    ketamine    accelerated    dynamics    suggesting    dynamic    infusion    antagonist    vivo    exact    depressive    applicability    voxels    subjects    unclear    voxel    baseline    sv    understand    anterior   

Project "GLU-IMAGE" data sheet

The following table provides information about the project.

Coordinator
MEDIZINISCHE UNIVERSITAET WIEN 

Organization address
address: SPITALGASSE 23
city: WIEN
postcode: 1090
website: www.meduniwien.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Total cost 186˙167 €
 EC max contribution 186˙167 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-07-01   to  2021-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MEDIZINISCHE UNIVERSITAET WIEN AT (WIEN) coordinator 186˙167.00

Map

 Project objective

While clinical experience confirmed ketamine, a glutamate (Glu) N-methyl-D-aspartate receptor antagonist, as a potent therapy of treatment-resistant major depressive disorder (TRD), the exact mechanism of ketamine’s action in the brain is unclear. Thus, a method to reliably and reproducibly monitor minute changes in Glu metabolism in the human brain is urgently needed to understand ketamine dynamics in vivo. So far, the pioneering work at the Medical University Vienna (MUW) showed ketamine-induced increase of vascular and metabolic responses measured as blood oxygenation level dependent (BOLD) signals in healthy subjects in thalamus, insula and anterior cingulate cortex (ACC), while others observed elevated glucose uptake using positron emission tomography, suggesting higher energetic demands and Glu response after ketamine infusion. Yet, a reliable and non-invasive method for direct monitoring of pharmacologically-induced dynamic Glu changes is still missing. Our group at MUW has recently developed a novel ground-breaking accelerated method for ultra-short echo time MRS imaging (UTE-MRSI) providing optimal Glu measures with critical sensitivity improvements compared to conventional proton single-voxel MRS (SV-MRS) and previously utilized MRSI approaches. Our method allows monitoring of Glu responses selectively in activated voxels and overcomes low spatial resolution, and limited coverage of SV-MRS that is the current gold standard for measurement of Glu concentrations and its dynamic changes in vivo (functional SV-MRS). The further improvement of UTE-MRSI by the implementation of the novel real-time motion correction will boost its applicability in clinical human studies. Thus, our UTE-MRSI will offer image-based multi-slice measurements of baseline Glu concentrations and its responses to ketamine administration with the potential to clarify ketamine’s mechanism of action in patients with TRD, and will allow monitoring of other novel glutamatergic therapies.

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