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Biosensor Design SIGNED

Engineering Chemotactic Biosensors for a Diverse Spectrum of Metastatic Markers

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 Biosensor Design project word cloud

Explore the words cloud of the Biosensor Design project. It provides you a very rough idea of what is the project "Biosensor Design" about.

circulation    secreted    soluble    fundamental    engineering    cytotoxic    extravasation    tumor    points    lethal    scaffold    opportunity    molecular    malignant    stringent    indicators    platform    cues    complexity    biophysical    potency    host    therapeutics    chemotactic    validate    structure    elicit    translational    journey    proliferate    biosensors    cancers    niches    sensing    environmental    barth    vulnerable    actions    immune    tumors    chemotaxis    function    lab    markers    migration    secondary    escape    initial    extensive    distant    receptors    diversity    nk    engineered    molecules    spectrum    biologists    metastatic    reaching    cells    form    protein    metastasis    initiate    movement    membrane    chemokine    synthetic    receptor    organ    migratory    harnessing    employ    biosensor    extremely    modulation    computational    relevance    techniques    cancer    rational    seed    biology    cell    immunosurveillance    ultimately    basic    directional    sites    expand    computation    intravasation   

Project "Biosensor Design" data sheet

The following table provides information about the project.

Coordinator
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE 

Organization address
address: BATIMENT CE 3316 STATION 1
city: LAUSANNE
postcode: 1015
website: www.epfl.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 191˙149 €
 EC max contribution 191˙149 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-02-01   to  2022-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH (LAUSANNE) coordinator 191˙149.00

Map

 Project objective

Directional movement of cells in response to environmental cues (e.g. chemotaxis) is essential throughout biology, and the membrane receptors that initiate cell migration offer a key opportunity for modulation by synthetic biologists. The design of chemotactic receptor biosensors for metastatic markers has the potential to expand the immune system’s spectrum of actions. Metastatic cancers are extremely lethal, and tumor cells that escape to seed a secondary tumor in a distant organ often escape immunosurveillance. Extensive studies on metastasis have identified soluble secreted factors that promote the initial escape of tumor cells, their intravasation into circulation, and extravasation into metastatic niches where they can proliferate and form new malignant tumors. We will employ a host of computational design techniques developed in the Barth Lab to build novel biosensors that will elicit chemotactic responses towards molecular indicators of metastatic cells at various key points during their journey to secondary sites when they are vulnerable to engineered cytotoxic immune (T and NK) cells. By harnessing the migratory potency of a chemokine receptor scaffold, we will design several novel chemotactic receptors sensing molecules of increasing complexity to ultimately build and validate a general computation-based platform for rational biosensor design. At a fundamental level, engineering membrane receptors that can respond to a diversity of molecules is a stringent test of our biophysical understanding of protein structure and function, but also has far-reaching applications in basic and translational research with immediate relevance and impact for cancer therapeutics.

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The information about "BIOSENSOR DESIGN" are provided by the European Opendata Portal: CORDIS opendata.

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