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SUBNETVIS SIGNED

Identifying subtype specific networks involved in sensory representation in mouse primary visual cortex

Total Cost €

EC-Contrib. €

Partnership

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SUBNETVIS project word cloud

Explore the words cloud of the SUBNETVIS project. It provides you a very rough idea of what is the project "SUBNETVIS" about.

modulation subpopulation single identification subpopulations cortical perform giving university correspond throughput kenneth poorly few neurons preference mouse thought arise properties diverse involvement stimuli transcriptomics decipher primary connectivity london professors situ posteriori cerebral behaviors led neuronal tuning share cell explore experiments preferentially connections populating harris integrates mainly cortex carandini functions interestingly specific broad computation fixed responding functional diversity accordingly transcriptomic signature matteo identity brain laboratory found extract monosynaptic interact encode certain fine college locomotor combining provides technique visual tracing initiated link structured vivo unexplored leaving relationships tissue recorded connected sensory

Project "SUBNETVIS" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	212˙933 €
EC max contribution	212˙933 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2018
Funding Scheme	MSCA-IF-EF-ST
Starting year	2020
Duration (year-month-day)	from 2020-04-01 to 2022-03-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITY COLLEGE LONDON UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	coordinator	212˙933.00

Map

Project objective

To produce relevant behaviors, the brain integrates and processes sensory information. Neurons in the primary visual cortex extract sensory information by responding preferentially to certain visual features. This feature preference, or tuning, is thought to arise from structured connections established between cortical neurons. Accordingly, it was found that connected neurons in the cerebral cortex share similar tuning properties. Interestingly, the neurons populating the cerebral cortex correspond to numerous neuronal subpopulations, involved in different functions. However, the functional involvement of this large neuronal diversity in cortical computation has been so far studied for a few broad neuronal subpopulations, leaving the fine subpopulations mainly unexplored. Do these poorly studied neuronal subpopulations share similar tuning properties? Is the structured connectivity giving rise to tuning subpopulation specific? I will use a new technique referred as in situ transcriptomics to study the tuning properties and locomotor modulation of the diverse neuronal subpopulations in the mouse primary visual cortex. This technique provides high throughput identification of neuronal subpopulations on fixed tissue based on the transcriptomic signature of neurons. I will thus determine the identity of in vivo recorded neurons a posteriori and decipher the relationships between cell identity and responses to visual stimuli. Combining this approach with single cell initiated monosynaptic tracing, I will then explore the link between subpopulation specific connectivity and tuning properties. This project will greatly contribute to the understanding of how cortical neuronal subpopulations interact to encode sensory information. I will perform these experiments in the Cortical Processing Laboratory at University College London, led by Professors Kenneth Harris and Matteo Carandini.

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The information about "SUBNETVIS" are provided by the European Opendata Portal: CORDIS opendata.