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SUBNETVIS SIGNED

Identifying subtype specific networks involved in sensory representation in mouse primary visual cortex

Total Cost €

EC-Contrib. €

Partnership

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SUBNETVIS project word cloud

Explore the words cloud of the SUBNETVIS project. It provides you a very rough idea of what is the project "SUBNETVIS" about.

tracing diverse interestingly certain properties leaving behaviors computation locomotor situ stimuli modulation structured subpopulation identification laboratory encode provides led cerebral transcriptomics involvement found recorded harris preference giving poorly transcriptomic explore few cortical specific broad monosynaptic professors matteo relationships kenneth tissue perform carandini neurons cell experiments identity posteriori throughput link diversity decipher interact responding preferentially college fixed technique cortex mainly single integrates primary combining thought fine functional vivo university extract unexplored accordingly arise share connectivity functions brain subpopulations visual initiated london neuronal connected connections mouse sensory populating signature correspond tuning

Project "SUBNETVIS" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	212˙933 €
EC max contribution	212˙933 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2018
Funding Scheme	MSCA-IF-EF-ST
Starting year	2020
Duration (year-month-day)	from 2020-04-01 to 2022-03-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITY COLLEGE LONDON UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	coordinator	212˙933.00

Map

Project objective

To produce relevant behaviors, the brain integrates and processes sensory information. Neurons in the primary visual cortex extract sensory information by responding preferentially to certain visual features. This feature preference, or tuning, is thought to arise from structured connections established between cortical neurons. Accordingly, it was found that connected neurons in the cerebral cortex share similar tuning properties. Interestingly, the neurons populating the cerebral cortex correspond to numerous neuronal subpopulations, involved in different functions. However, the functional involvement of this large neuronal diversity in cortical computation has been so far studied for a few broad neuronal subpopulations, leaving the fine subpopulations mainly unexplored. Do these poorly studied neuronal subpopulations share similar tuning properties? Is the structured connectivity giving rise to tuning subpopulation specific? I will use a new technique referred as in situ transcriptomics to study the tuning properties and locomotor modulation of the diverse neuronal subpopulations in the mouse primary visual cortex. This technique provides high throughput identification of neuronal subpopulations on fixed tissue based on the transcriptomic signature of neurons. I will thus determine the identity of in vivo recorded neurons a posteriori and decipher the relationships between cell identity and responses to visual stimuli. Combining this approach with single cell initiated monosynaptic tracing, I will then explore the link between subpopulation specific connectivity and tuning properties. This project will greatly contribute to the understanding of how cortical neuronal subpopulations interact to encode sensory information. I will perform these experiments in the Cortical Processing Laboratory at University College London, led by Professors Kenneth Harris and Matteo Carandini.

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The information about "SUBNETVIS" are provided by the European Opendata Portal: CORDIS opendata.