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miRhythm SIGNED

Understanding mechanisms and functions of miRNA oscillations during development

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 miRhythm project word cloud

Explore the words cloud of the miRhythm project. It provides you a very rough idea of what is the project "miRhythm" about.

lab    fundamental    molecular    transcript    diverse    uncover    mechanisms    peaking    cell       mirna    oscillation    once    delineate    function    host    period    largely    stage    surprising    metabolism    organismal    orchestration    larval    combination    paradigm    oscillatory    genetic    of    timers    gene    progression    mostly    exhibit    stable    remained    proliferation    principles    precise    transcription    nematode    bioinformatics    additional    organism    developmental    biophysics    differentiation    mirnas    genes    amplitudes    exactly    tracking    sufficiently    timing    appear    migration    amplitude    hr    single    events    uncovered    oscillations    cuticle    biological    orchestrate    careful    generally    quite    tractability    small    render    periodic    encompassing    relies    rely    unstable    sequencing    successful    repetitive    enigmatic    synthesis    elegans    throughput    regulatory    assets    rhythmic    experimental    expression    2700    temporal    reproducibility    shedding   

Project "miRhythm" data sheet

The following table provides information about the project.

Coordinator
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION 

Organization address
address: MAULBEERSTRASSE 66
city: BASEL
postcode: 4058
website: www.fmi.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 203˙149 €
 EC max contribution 203˙149 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION CH (BASEL) coordinator 203˙149.00

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 Project objective

Successful development of an organism relies on careful temporal orchestration of a large number of diverse events. Although processes such as cell proliferation, migration and differentiation are thus under precise temporal control, molecular mechanisms of the relevant biological timers have remained largely enigmatic. I propose to exploit the repetitive development and robust oscillatory gene expression of the nematode C. elegans to identify fundamental principles of temporal control of organismal development through rhythmic gene expression. High temporal reproducibility of developmental progression and genetic tractability are additional major assets of this novel experimental paradigm. Previous work in my host-lab uncovered high-amplitude oscillatory expression of ~2700 genes peaking exactly once per larval stage, with an ~8-hr period. These oscillations appear to orchestrate periodic developmental events encompassing synthesis and shedding of the cuticle, cell proliferation and differentiation. A small set of regulatory miRNAs also exhibit oscillations with large amplitudes. This is surprising given that miRNAs are generally quite stable, and that the transcript level oscillations appear to be rely mostly on rhythmic transcription. Here, I propose to delineate the function of oscillatory miRNAs in rhythmic gene expression and development, and the mechanisms that render them sufficiently unstable to facilitate oscillation. Thus, through a combination of high-throughput developmental tracking, single-cell sequencing, bioinformatics, and biophysics approaches, I expect to uncover molecular mechanisms that control developmental timing and miRNA metabolism.

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The information about "MIRHYTHM" are provided by the European Opendata Portal: CORDIS opendata.

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