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PMSMatTrain SIGNED

Novel Biomaterial-based Device for the Treatment of Progressive MS- - An Integrated Pan- European Approach

Total Cost €

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EC-Contrib. €

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Partnership

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PMSMatTrain project word cloud

Explore the words cloud of the PMSMatTrain project. It provides you a very rough idea of what is the project "PMSMatTrain" about.

molecular silico scaffolds basics scaled esrs joint education progressive vivo utilise spectrophotometry protocols time mass hyaluronan release patient cgmp policy oligodendrocyte property tested skills therapy talk drug industry manufacturing standardised quality degenerative regulatory sclerosis innovation complementary arising designed gaining disease leadership mri pmsmattrain jrtp chronic proximal entrepreneurship spif beneficiaries modal cell april immediately evaluation multiple weight model mechanisms neuroprotection commercialisation neuroprotective recruited intellectual affairs translation stage training followed stem elusion smes functionalised cns biomimetic cortex axonal employable discipline neuroinflammation ibudilast cross modifying compulsory demyelination dispersal directed cultures organotypic pms signals inflammatory yield biomaterials ms first drugs medical pathophysiology miconazole remyelination clinically generate molecules device characterised small tool transferable receive anti gender

Project "PMSMatTrain" data sheet

The following table provides information about the project.

Coordinator	NATIONAL UNIVERSITY OF IRELAND GALWAY Organization address address: UNIVERSITY ROAD city: Galway postcode: H91 website: www.nuigalway.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Ireland [IE]
Total cost	3˙962˙143 €
EC max contribution	3˙962˙143 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2018
Funding Scheme	MSCA-ITN-ETN
Starting year	2019
Duration (year-month-day)	from 2019-05-01 to 2023-04-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	NATIONAL UNIVERSITY OF IRELAND GALWAY NATIONAL UNIVERSITY OF IRELAND GALWAY Organization address address: UNIVERSITY ROAD city: Galway postcode: H91 website: www.nuigalway.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (Galway)	coordinator	1˙373˙421.00
2	UNIVERSITEIT ANTWERPEN UNIVERSITEIT ANTWERPEN Organization address address: PRINSSTRAAT 13 city: ANTWERPEN postcode: 2000 website: www.ua.ac.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (ANTWERPEN)	participant	512˙640.00
3	WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER Organization address address: SCHLOSSPLATZ 2 city: MUENSTER postcode: 48149 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENSTER)	participant	505˙576.00
4	NEOS SURGERY SL NEOS SURGERY SL Organization address address: PASEO MIKELETEGI - PARQUE TECNOLOGICO MIRAMON 2 city: DONOSTIA SAN SEBASTIAN postcode: 20009 website: www.neosurgery.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (DONOSTIA SAN SEBASTIAN)	participant	501˙809.00
5	SYDDANSK UNIVERSITET SYDDANSK UNIVERSITET Organization address address: CAMPUSVEJ 55 city: ODENSE M postcode: 5230 website: www.sdu.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (ODENSE M)	participant	297˙522.00
6	UNIVERSITE GRENOBLE ALPES UNIVERSITE GRENOBLE ALPES Organization address address: 621 AVENUE CENTRALE city: GRENOBLE postcode: 38058 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (GRENOBLE)	participant	274˙802.00
7	UNIVERSITA DEGLI STUDI GABRIELE D'ANNUNZIO DI CHIETI-PESCARA UNIVERSITA DEGLI STUDI GABRIELE D'ANNUNZIO DI CHIETI-PESCARA Organization address address: Via dei Vestini 31 city: CHIETI postcode: 66013 website: www.unich.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (CHIETI)	participant	261˙499.00
8	CONTIPRO AS CONTIPRO AS Organization address address: DOLNI DOBROUC 401 city: DOLNI DOBROUC postcode: 561 02 website: www.contipro.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CZ (DOLNI DOBROUC)	participant	234˙871.00
9	UNIVERSITE GRENOBLE ALPES UNIVERSITE GRENOBLE ALPES Organization address address: 621, AVENUE CENTRALE city: SAINT MARTIN D'HERES postcode: 38401 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (SAINT MARTIN D'HERES)	participant	0.00

Map

Project objective

PMSMatTrain is focusing on gaining a comprehensive understanding of the progressive (late degenerative phase) of multiple sclerosis (PMS) from basics to translation, fully supported by 8 beneficiaries (6 research institutions, 2 SMEs). Recruited ESRs will receive compulsory discipline-specific, generic and complementary transferable skills training. PMSMatTrain’s Joint Research Education and Training programme (JRTP) will provide early stage researchers with high quality research and transferable skills training in intellectual property, leadership skills, innovation, regulatory affairs, entrepreneurship, gender policy, and medical device evaluation, which will ensure that they are immediately employable in industry. The consortium will develop a multi-modal hyaluronan-based medical device designed to release small molecular weight anti-inflammatory molecules (APRIL and sPIF) followed by remyelination and neuroprotective drugs (ibudilast and miconazole). PMSMatTrain will for the first time utilise these functionalised multi-modal biomimetic hyaluronan scaffolds as a tool to investigate cross-talk between signals arising due to chronic neuroinflammation and those leading to demyelination and axonal loss, while identifying molecular mechanisms that facilitate remyelination and neuroprotection in PMS. This approach could yield the first cortex-proximal and directed biomaterials-based disease-modifying therapy for PMS. These scaffolds will be tested in state of the art MS patient induced stem cell-derived oligodendrocyte cultures and organotypic cultures to investigate MS pathophysiology. In vivo responses will be characterised using field-leading MRI and mass spectrophotometry protocols. PMSMatTrain will also generate a clinically-relevant in silico model of drug elusion and dispersal within the CNS. Our industry partners will develop the end-device by providing standardised manufacturing protocols for scaled-up production and commercialisation of the cGMP product.

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The information about "PMSMATTRAIN" are provided by the European Opendata Portal: CORDIS opendata.

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