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GPCR-Sensor SIGNED

GPCR-based biosensor for synthetic biology applications

Total Cost €

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EC-Contrib. €

0

Partnership

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 GPCR-Sensor project word cloud

Explore the words cloud of the GPCR-Sensor project. It provides you a very rough idea of what is the project "GPCR-Sensor" about.

extensive    permits    enzymes    career    versatile    synthetic    encountered    enzyme    internationally    expertise    monitoring    independent    epitopes    lack    hurdles    strains    mentoring    powerful    entities    launching    yields    rising    plugging    medical    economical    variety    optimized    microbial    alternative    frequently    biosynthetic    accumulation    hosts    leadership    integral    efficient    valuable    combine    interdisciplinary    chemicals    diagnostics    close    drug    overcome    competitive    sense    samples    pathogen    fund    engineering    protein    recognition    biochemical    biotechnology    establishing    sustainable    professional    communication    academic    gpcr    line    pharmaceuticals    sensor    principles    skills    biology    industrially    create    me    yeast    instrumental    metabolic    limitation    pollutants    training    cell    factories    biosensor    bio    throughput    harness    industrial    coupled    eukaryotes    teaching    enzymology    natural    acquire    environment    vivo    structure    discovery    environmental    molecular    gpcrs    biosynthesis    modular    receptors   

Project "GPCR-Sensor" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 207˙312 €
 EC max contribution 207˙312 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-06-01   to  2022-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 207˙312.00

Map

 Project objective

Microbial cell factories are an economical and sustainable alternative for the production of pharmaceuticals, industrial chemicals and other valuable chemicals. However, establishing efficient cell factories requires optimized production strains and efficient biosynthetic enzymes, and involves extensive protein and metabolic engineering to achieve industrially relevant yields. One of the main hurdles frequently encountered in this process is the lack of high-throughput methods for monitoring product accumulation. To overcome this limitation, I will harness G-protein coupled receptors (GPCRs), the unique molecular entities that eukaryotes use to sense their environment, to create a versatile in vivo biosensor. I will apply synthetic biology principles and an interdisciplinary approach to develop a yeast-based GPCR biosensor for the engineering of enzymes and production hosts. However, enzyme engineering is only one of the potential applications of GPCR-sensor. Its modular structure permits plugging in any GPCR, enabling a great variety of other powerful applications including bio-medical applications, such as recognition of pathogen epitopes, molecular diagnostics and drug discovery, or environmental applications, such as determining the presence of pollutants from environmental samples. In the GPCR-sensor project, I will combine my knowledge in natural product biosynthesis and enzymology with training in biochemical engineering and biotechnology to acquire a unique expertise that will help me establish my own unique line of research. Furthermore, the comprehensive professional development program, that is an integral part of GPCR-sensor, includes close mentoring in addition to training in fund-rising, research management, communication, teaching and academic leadership. These skills that are Instrumental for launching my future independent internationally competitive research career

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The information about "GPCR-SENSOR" are provided by the European Opendata Portal: CORDIS opendata.

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