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Opendata, web and dolomites

HELP SIGNED

Collaboration for innovation: Establishment of a pan-nematode drug development platform

Total Cost €

EC-Contrib. €

Partnership

Views

HELP project word cloud

Explore the words cloud of the HELP project. It provides you a very rough idea of what is the project "HELP" about.

goals multiple breaking adult pipeline diseases data co clinical profile regulatory proven helminthiasis mechanism sdg proposes good compound onchocerciasis endosymbionts treat exploratory tropical preclinical action toxicity nor celgene strategy prospects populate benefit health sterilize doxycycline elimination oxfendazol nematodes chemotherapeutics industrial shift candidates efficacy pamoate humans paradigm species anthelminthics transmitted filariae fail superiority treating compounds horizon gold infections eliminate pan stages drugs guidelines upcoming 2030 endemic preselected bayer oxantel helminth corallopyronin nematode drug worms soil bioavailability efficacious excellent profiling standard ground safety wolbachia undergo trials progressed animals collaborations

Project "HELP" data sheet

The following table provides information about the project.

Coordinator	SCHWEIZERISCHES TROPEN- UND PUBLIC HEALTH-INSTITUT Organization address address: SOCINSTRASSE 57 city: Basel postcode: CH-4002 website: www.swisstph.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Switzerland [CH]
Total cost	0 €
EC max contribution	8˙713˙395 € (0%)
Programme	1. H2020-EU.3.1.3. (Treating and managing disease)
Code Call	H2020-SC1-2018-Two-Stage-RTD
Funding Scheme	RIA-LS
Starting year	2019
Duration (year-month-day)	from 2019-09-01 to 2024-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	SCHWEIZERISCHES TROPEN- UND PUBLIC HEALTH-INSTITUT SCHWEIZERISCHES TROPEN- UND PUBLIC HEALTH-INSTITUT Organization address address: SOCINSTRASSE 57 city: Basel postcode: CH-4002 website: www.swisstph.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (Basel)	coordinator	3˙385˙143.00
2	DRUGS FOR NEGLECTED DISEASES INITIATIVE FONDATION DNDI DRUGS FOR NEGLECTED DISEASES INITIATIVE FONDATION DNDI Organization address address: CHEMIN LOUIS DUNANT 15 city: GENEVE postcode: 1202 website: www.dndi.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (GENEVE)	participant	2˙285˙375.00
3	UNIVERSITATSKLINIKUM BONN UNIVERSITATSKLINIKUM BONN Organization address address: VENUSBERG-CAMPUS 1 city: BONN postcode: 53127 website: www.ukb.uni-bonn.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BONN)	participant	1˙839˙714.00
4	IFAKARA HEALTH INSTITUTE TRUST IFAKARA HEALTH INSTITUTE TRUST Organization address address: KIKO AVENUE OFF OLD BAGAMOYO ROAD PLOT 463 city: DAR ES SALAAM postcode: n.a. website: http://www.ihi.or.tz/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	TZ (DAR ES SALAAM)	participant	820˙506.00
5	MUSEUM NATIONAL D'HISTOIRE NATURELLE MUSEUM NATIONAL D'HISTOIRE NATURELLE Organization address address: RUE CUVIER 57 city: PARIS postcode: 75005 website: http://www.mnhn.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	284˙500.00
6	UNIVERSITY OF BUEA UNIVERSITY OF BUEA Organization address address: PO BOX 63 city: BUEA SOUTHWEST REGION postcode: n.a. website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CM (BUEA SOUTHWEST REGION)	participant	98˙156.00
7	BAYER ANIMAL HEALTH GMBH BAYER ANIMAL HEALTH GMBH Organization address address: KAISER WILHLEM ALLEE 50 city: LEVERKUSEN postcode: 51373 website: www.bayerhealthcare.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (LEVERKUSEN)	participant	0.00
8	CELGENE MANAGEMENT SARL CELGENE MANAGEMENT SARL Organization address address: ROUTE DE PERREUX 1 city: BOUDRY postcode: 2017 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (BOUDRY)	participant	0.00

Map

Project objective

To target helminth elimination, a drug research and development (R&D) pipeline is needed to provide new chemotherapeutics that effectively eliminate or sterilize adult worms, thus bringing about the paradigm shift necessary to reach the 2030 SDG goals on health. Our consortium proposes to establish a R&D pipeline for anthelminthics targeting nematodes. The focus will be on soil-transmitted helminthiasis and onchocerciasis, since these infections are among the leading neglected tropical diseases. Ground breaking characteristics of the drugs developed within our project are that they will have a unique mechanism of action that, at best, will target multiple nematodes (pan-nematode) with an excellent safety profile, including no efficacy against non-targeted co-endemic species. We will benefit from collaborations with our industrial partners Bayer and Celgene providing preselected compounds to populate the early preclinical stages of the R&D pipeline. Compounds with the best profile will be progressed through preclinical studies. Corallopyronin A, a compound with proven efficacy against essential Wolbachia endosymbionts in filariae that has superiority to the gold standard doxycycline, excellent bioavailability and promising exploratory safety data will undergo state-of-the-art toxicity profiling to advance towards phase 1 trials. We will also evaluate oxfendazol and oxantel pamoate in clinical trials. They have already proven efficacious in animals or humans and will only require clinical trials according to current regulatory guidelines to be implemented. With this strategy, the consortium will ensure that a pipeline of drug candidates is available for treating onchocerciasis, especially should current candidates fail in upcoming clinical trials. Moreover, we will establish a much-needed drug R&D pipeline to treat soil-transmitted helminth infections for which there is currently neither a drug with good efficacy against all species nor any prospects on the horizon.

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The information about "HELP" are provided by the European Opendata Portal: CORDIS opendata.