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ARTimmune SIGNED

Programmable ARTificial immune systems to fight cancer

Total Cost €

0

EC-Contrib. €

0

Partnership

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 ARTimmune project word cloud

Explore the words cloud of the ARTimmune project. It provides you a very rough idea of what is the project "ARTimmune" about.

infiltration    life    intelligent    lymph    illustrate    proteolytic    cancer    generate    architecture    roadblocks    sponge    branched    polymeric    entered    decorated    transcriptomics    immunological    advantage    obstacles    immunotherapy    immune    overcome    communication    dose    tumour    destruction    cell    tolerable    treatment    molecules    fundamental    notwithstanding    modality    vaccinated    chemical    blueprint    direct    patients    locally    toxicity    tools    injected    programmable    hypothesize    single    local    node    immunomodulating    powerhouses    programming    powerful    centre    bursts    accomplished    revolutionary    act    scaffolds    artimmune    follow    cells    tuning    span    porosity    fine    successful    radically    revolutionize    stage    mixed    structures    systemic    instruct    extend    niches    toxic    ln    activation    injectable    character    moving    immunomodulators    maximal    synthetic    vivo    innovative    function    immunotherapies    clusters    vicinity    mimic    pressing    immunosuppression    cytotoxic   

Project "ARTimmune" data sheet

The following table provides information about the project.

Coordinator
STICHTING KATHOLIEKE UNIVERSITEIT 

Organization address
address: GEERT GROOTEPLEIN NOORD 9
city: NIJMEGEN
postcode: 6525 EZ
website: www.radboudumc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-11-01   to  2024-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING KATHOLIEKE UNIVERSITEIT NL (NIJMEGEN) coordinator 2˙500˙000.00

Map

 Project objective

Immunotherapy has entered centre stage as a novel treatment modality for cancer. Notwithstanding this major step forward, toxicity and immunosuppression remain major obstacles, and illustrate the pressing need for more powerful and specific immunotherapies against cancer. To overcome these roadblocks, in ARTimmune, I propose to follow a radically different approach by developing local rather than systemic immunotherapies. Taking advantage of the architecture of a lymph node (LN), I aim to design fully synthetic immune niches to locally instruct immune cell function. I hypothesize that programmable synthetic immune niches, when injected next to a tumour, will act as local powerhouses to generate bursts of cytotoxic T cells for tumour destruction, without toxic side effects. Single cell transcriptomics on LN, obtained from patients that are vaccinated against cancer, will provide unique insight in communication within immune cell clusters and provide a blueprint for the intelligent design of synthetic immune niches. Chemical tools will be used to build branched polymeric structures decorated with immunomodulating molecules to mimic LN architecture. These will be injected, mixed with sponge-like scaffolds to provide porosity needed for immune cell infiltration. Programming of immune cell function will be accomplished by in vivo targeting- and proteolytic activation- of immunomodulators for fine-tuning, and to extend the life span of these local powerhouses. The innovative character of ARTimmune comes from: 1) novel fundamental immunological insight in complex communication within LN cell clusters, 2) a revolutionary new approach in immunotherapy, by the development of 3) injectable- and 4) programmable- synthetic immune niches by state-of-the-art chemical technology. When successful, it will revolutionize cancer immunotherapy, moving from maximal tolerable dose systemic treatment with significant toxicity to local low dose treatment in the direct vicinity of a tumour

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The information about "ARTIMMUNE" are provided by the European Opendata Portal: CORDIS opendata.

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