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TWO-BIRDS SIGNED

A feasibility study for SYT-510, a first-in-class drug to treat neuropsychiatric disorders through restoring overall balance in brain chemistry

Total Cost €

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EC-Contrib. €

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Partnership

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 TWO-BIRDS project word cloud

Explore the words cloud of the TWO-BIRDS project. It provides you a very rough idea of what is the project "TWO-BIRDS" about.

co    intrusive    ready    function    pharma    severe    combined    paradigm    pharmaceutical    regulate    pharmacokinetic    510    million    understand    sales    feasibility    clinical    safety    population    regulatory    synendos    relief    mechanism    never    symptoms    safe    chemistry    investor    sustainable    action    start    reuptake    trauma    drug    traumatic    stage    nightmares    ineffective    self    syt    consolidate    termed    companies    relive    family    circuit    victims    triggers    15    plan    downstream    birds    thoughts    demonstrated    disrepair    balance    attractive    commercialize    compound    psychological    manner    selective    patient    disorder    thereby    unfortunately    modulate    preclinical    provoke    people    neural    business    hold    drugs    unforgiving    treatment    limiting    small    restoring    circuits    dysregulated    partnering    first    market    anxiety    inhibitors    post    cognitive    brain    flashbacks    experiences    clinician    deals    anti    chemistries    establishing    endocx    final    dependency    stress    patients    eventual    disorders    70    restore    seris    risk    molecule    ptsd    master    profile    coerced    neuroregulator    endocannabinoid   

Project "TWO-BIRDS" data sheet

The following table provides information about the project.

Coordinator		 SYNENDOS THERAPEUTICS AG 

Organization address
address: SWISS INNOVATION PARK, GEWERBESTRASSE 24
city: ALLSCHWIL
postcode: 4123
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Switzerland [CH]
 Total cost 71˙429 €
 EC max contribution 50˙000 € (70%)
 Programme 1. H2020-EU.3. (PRIORITY 'Societal challenges)
2. H2020-EU.2.3. (INDUSTRIAL LEADERSHIP - Innovation In SMEs)
3. H2020-EU.2.1. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies)
 Code Call H2020-SMEInst-2018-2020-1
 Funding Scheme SME-1
 Starting year 2019
 Duration (year-month-day) from 2019-08-01   to  2020-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    SYNENDOS THERAPEUTICS AG CH (ALLSCHWIL) coordinator 50˙000.00

Map

 Project objective

PTSD affects over 15 million people in Europe. So far, 70% never find relief. New drugs that restore the endocannabinoid (endoCx) neural circuit hold potential to change this paradigm.

Post-traumatic stress disorder, known as PTSD, is one of the most unforgiving psychological disorders. As victims of trauma, PTSD patients are coerced by their dysregulated brain chemistries to relive their traumatic experiences, where specific triggers provoke symptoms such as flashbacks, intrusive thoughts, nightmares and severe anxiety. Unfortunately, current drugs address only specific downstream neural circuits and are highly ineffective. The endoCx is highly dysregulated in PTSD, and as a 'master neuroregulator', drugs that restore its function in a safe and sustainable manner have strong potential to be the first effective treatment for PTSD.

Synendos is a pharmaceutical start-up who have identified a new family of drugs that modulate the endoCx via a new mechanism-of-action. Termed SERIs, or, ‘selective endocannabinoid reuptake inhibitors’, these small molecule drugs regulate the endoCx system in a self-limiting manner, thereby restoring balance to brain chemistry without risk of drug dependency or cognitive disrepair. Our lead compound SYT-510 is at the stage of preclinical development, where it has demonstrated effective anti-anxiety activity, favourable pharmacokinetic characteristics and a strong safety profile.

We aim to commercialize SYT-510 through establishing partnering deals with pharma companies for its co-development and eventual sales. With a patient population of over 30 million (in EU/US combined), PTSD is an attractive market for drug development.

TWO-BIRDS project: The main aims of this feasibility study are to 1) work to further understand clinician and patient needs, 2) define a detailed plan for final preclinical, clinical and regulatory activities and 3) consolidate new information into an investor-ready business plan.

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The information about "TWO-BIRDS" are provided by the European Opendata Portal: CORDIS opendata.

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