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ENHPATHY SIGNED

Molecular basis of human enhanceropathies

Total Cost €

EC-Contrib. €

Partnership

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ENHPATHY project word cloud

Explore the words cloud of the ENHPATHY project. It provides you a very rough idea of what is the project "ENHPATHY" about.

least cutting disruption edge mechanistic multidisciplinary enhancer cancer molecular ageing post broad considering limited vitro gene ombined strategies epigenetic genes biology mutations disorders implications structural models congenital group clear basis genomic network reflects predicted partial disease elucidating diagnostic sequences reaching landscapes uncovered enhancers engineering private partly translating regulatory vivo transcriptional diabetes pandemic genetic ranging stage diverse proportions primitive chiefly expression whereby utilize pathological training enhpathy mechanisms therapeutic consequently translational enhanceropathies etiological acquiring human display diseases equally rare coding believe hypothesize

Project "ENHPATHY" data sheet

The following table provides information about the project.

Coordinator	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Organization address address: RUE DE TOLBIAC 101 city: PARIS postcode: 75654 website: www.inserm.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Total cost	3˙992˙397 €
EC max contribution	3˙992˙397 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2019
Funding Scheme	MSCA-ITN-ETN
Starting year	2020
Duration (year-month-day)	from 2020-03-01 to 2024-02-29

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Organization address address: RUE DE TOLBIAC 101 city: PARIS postcode: 75654 website: www.inserm.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	coordinator	274˙802.00
2	KOBENHAVNS UNIVERSITET KOBENHAVNS UNIVERSITET Organization address address: NORREGADE 10 city: KOBENHAVN postcode: 1165 website: www.ku.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KOBENHAVN)	participant	297˙522.00
3	SYDDANSK UNIVERSITET SYDDANSK UNIVERSITET Organization address address: CAMPUSVEJ 55 city: ODENSE M postcode: 5230 website: www.sdu.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (ODENSE M)	participant	297˙522.00
4	KUNGLIGA TEKNISKA HOEGSKOLAN KUNGLIGA TEKNISKA HOEGSKOLAN Organization address address: BRINELLVAGEN 8 city: STOCKHOLM postcode: 100 44 website: www.kth.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	participant	281˙982.00
5	ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE Organization address address: BATIMENT CE 3316 STATION 1 city: LAUSANNE postcode: 1015 website: www.epfl.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (LAUSANNE)	participant	281˙276.00
6	ADVANCED BIODESIGN ADVANCED BIODESIGN Organization address address: LES ALLEES DU PARC, 575/655 ALLEE D city: SAINT-PRIEST postcode: 69800 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (SAINT-PRIEST)	participant	274˙802.00
7	ELVESYS ELVESYS Organization address address: 1-3 BIS RUE ROBERT ET SONIA DELAUNAY city: PARIS postcode: 75011 website: www.elvesys.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	274˙802.00
8	GEN-X BV GEN-X BV Organization address address: ERASMUSGRACHT 59H city: AMSTERDAM postcode: 1056 BG website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	participant	265˙619.00
9	KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW Organization address address: KLOVENIERSBURGWAL 29 HET TRIPPENHUIS city: AMSTERDAM postcode: 1011 JV website: www.knaw.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	participant	265˙619.00
10	HUMANITAS UNIVERSITY HUMANITAS UNIVERSITY Organization address address: VIA RITA LEVI MONTALCINI SNC city: PIEVE EMANUELE postcode: 20090 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (PIEVE EMANUELE)	participant	261˙499.00
11	EUROPEAN MOLECULAR BIOLOGY LABORATORY EUROPEAN MOLECULAR BIOLOGY LABORATORY Organization address address: Meyerhofstrasse 1 city: HEIDELBERG postcode: 69117 website: http://www.embl.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HEIDELBERG)	participant	252˙788.00
12	FUNDACIO CENTRE DE REGULACIO GENOMICA FUNDACIO CENTRE DE REGULACIO GENOMICA Organization address address: CARRER DOCTOR AIGUADER 88 city: BARCELONA postcode: 8003 website: www.crg.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	250˙904.00
13	UNIVERSIDAD DE CANTABRIA UNIVERSIDAD DE CANTABRIA Organization address address: AVENIDA DE LOS CASTROS S/N city: SANTANDER postcode: 39005 website: www.unican.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (SANTANDER)	participant	250˙904.00
14	USTAV MOLEKULARNI GENETIKY AKADEMIE VED CESKE REPUBLIKY VEREJNA VYZKUMNA INSTITUCE USTAV MOLEKULARNI GENETIKY AKADEMIE VED CESKE REPUBLIKY VEREJNA VYZKUMNA INSTITUCE Organization address address: VIDENSKA 1083 city: PRAHA 4 postcode: 142 20 website: www.img.cas.cz contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CZ (PRAHA 4)	participant	234˙871.00
15	UNIWERSYTET WARSZAWSKI UNIWERSYTET WARSZAWSKI Organization address address: KRAKOWSKIE PRZEDMIESCIE 26/28 city: WARSZAWA postcode: 00 927 website: www.uw.edu.pl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PL (WARSZAWA)	participant	227˙478.00

Map

Project objective

Mutations within coding genes have traditionally been considered the major genetic cause of human disease. However, it is becoming increasingly clear that the genetic, structural and/or epigenetic disruption of enhancers and enhancer landscapes represent major etiological factors in numerous human diseases (i.e. enhanceropathies), ranging from rare congenital disorders to common diseases associated with ageing (e.g. cancer, diabetes). Although changes in enhancer activity are predicted to have broad pathological and therapeutic implications, we currently have a limited mechanistic understanding of human enhanceropathies. This reflects, at least partly, our still primitive and partial understanding of the mechanisms whereby enhancers can control gene expression. We hypothesize that enhancers are a diverse group of regulatory sequences that can utilize different mechanisms to control gene expression at the transcriptional and/or post-transcriptional level. Consequently, human enhanceropathies are likely to display an equally diverse molecular basis that, we believe, can only be uncovered using highly multidisciplinary systems biology approaches. Chiefly, elucidating the molecular basis of human enhanceropathies has far reaching translational implications, especially considering the pandemic proportions that some of these disorders are acquiring in recent years. Therefore, the major goal of the ENHPATHY network is to provide early-stage researchers with a multidisciplinary training in which cutting-edge genomic and genetic engineering approaches are ombined with various in vitro and in vivo disease models. Moreover, together with our private partners we aim at translating our molecular findings into new diagnostic and therapeutic strategies.

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