Opendata, web and dolomites
IMMUNETREH SIGNED
Trehalose as a source for privileged immunity in Drosophila
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0IMMUNETREH project word cloud
Explore the words cloud of the IMMUNETREH project. It provides you a very rough idea of what is the project "IMMUNETREH" about.
fruit
immunity
host
privileged
energy
immunology
trehalose
fly
play
immune
metabolic
transporter
intracellularly
efficient
drosophila
vivo
researcher
metabolism
suggesting
genetic
models
insect
techniques
expertise
primary
multidisciplinary
evolutionary
manipulate
tissue
cell
combine
trait
culture
independent
convert
time
fundamental
activated
insulin
nutrients
mammalian
systemic
biology
glucose
idea
regulation
tools
physiology
demanding
completely
molecular
laboratory
infection
actually
carbohydrate
genetics
preferentially
preliminary
developmental
cells
sugar
metabolomics
instead
Project "IMMUNETREH" data sheet
The following table provides information about the project.
| Coordinator |
JIHOCESKA UNIVERZITA V CESKYCH BUDEJOVICICH
Organization address contact info |
| Coordinator Country | Czech Republic [CZ] |
| Total cost | 156˙980 € |
| EC max contribution | 156˙980 € (100%) |
| Programme |
1. H2020-EU.4. (SPREADING EXCELLENCE AND WIDENING PARTICIPATION) |
| Code Call | H2020-WF-01-2018 |
| Funding Scheme | MSCA-IF-EF-ST |
| Starting year | 2020 |
| Duration (year-month-day) | from 2020-01-01 to 2021-12-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | JIHOCESKA UNIVERZITA V CESKYCH BUDEJOVICICH | CZ (CESKE BUDEJOVICE) | coordinator | 156˙980.00 |
Map
Project objective
The immune response is an energy demanding process and immune cells must have a privileged access to energy/nutrients. While in mammalian system, this privileged access is achieved for example by insulin-independent glucose transporter, how is it achieved in insect is not known. The host laboratory has obtained preliminary results suggesting that the privileged access of fruit fly immune cells to nutrients might be achieved by using trehalose instead of glucose. It is known for a very long time that the primary sugar in insect is trehalose but it is a completely new idea that this carbohydrate could actually play an important role in the privileged access of immunity to resources, as in one of the most fundamental evolutionary trait. The goal of this project is therefore to test if activated Drosophila immune cells preferentially uptake trehalose and convert it to glucose intracellularly, being thus independent of the systemic carbohydrate regulation, and how important would it be for an efficient immune response. The project is based on a multidisciplinary approaches, when tissue-specific genetic tools will be used to manipulate metabolism in vivo in order to study immune response using techniques of molecular biology, developmental biology and immunology and state-of-the-art metabolic approaches. The goal for the researcher is to learn how to use Drosophila genetics and the infection models, well established in the host laboratory, and combine them with her expertise in insect physiology, cell culture and especially metabolomics.
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The information about "IMMUNETREH" are provided by the European Opendata Portal: CORDIS opendata.
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