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MISTRAL SIGNED

Microbiome-based stratification of individuals at risk of HIV-1 acquisition, chronic clinical complications,antimicrobial drug resistance,and unresponsiveness to therapeutic HIV-1 vaccination

Total Cost €

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EC-Contrib. €

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Partnership

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MISTRAL project word cloud

Explore the words cloud of the MISTRAL project. It provides you a very rough idea of what is the project "MISTRAL" about.

infection science stratification acquiring impacts repository curated 27 brings irreversibly web innovations critical world living soaring expertise drug millions cloud biomarkers smes outcome unlock beings mitigate designed closer suggest complementary efficacy treatment chronic biomarker full purposes resolved gut datasets tool viral successful inflammation accessible disorders outcomes public acquisition human interventions rationally risk streamlining discover eastern cancer interpretations despite software class immune complications 2010 automate applicable microbiome aids aging validate systemic antiretroviral mankind patient antimicrobial faced ideal benefit hiv host made cure deaths boost regions immunotherapies continues discoveries infections therapeutic 60 inform health immunotherapy team accelerated resistance diseases mechanistically clinical mistral stratify pandemic incorporated

Project "MISTRAL" data sheet

The following table provides information about the project.

Coordinator	FUNDACIO PRIVADA INSTITUT DE RECERCA DE LA SIDA-CAIXA Organization address address: CARRETERA DE CANYET city: BARCELONA postcode: 8916 website: www.irsicaixa.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Total cost	9˙994˙383 €
EC max contribution	9˙994˙383 € (100%)
Programme	1. H2020-EU.3.1.3. (Treating and managing disease)
Code Call	H2020-SC1-2019-Two-Stage-RTD
Funding Scheme	RIA
Starting year	2020
Duration (year-month-day)	from 2020-01-01 to 2024-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	FUNDACIO PRIVADA INSTITUT DE RECERCA DE LA SIDA-CAIXA FUNDACIO PRIVADA INSTITUT DE RECERCA DE LA SIDA-CAIXA Organization address address: CARRETERA DE CANYET city: BARCELONA postcode: 8916 website: www.irsicaixa.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	coordinator	3˙967˙500.00
2	KAROLINSKA INSTITUTET KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	participant	1˙490˙833.00
3	REGION HOVEDSTADEN REGION HOVEDSTADEN Organization address address: KONGENS VAENGE 2 city: HILLEROD postcode: 3400 website: www.regionh.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (HILLEROD)	participant	1˙017˙611.00
4	UNIVERSITE D'AIX MARSEILLE UNIVERSITE D'AIX MARSEILLE Organization address address: Boulevard Charles Livon 58 city: Marseille postcode: 13284 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (Marseille)	participant	730˙470.00
5	CASE WESTERN RESERVE UNIVERSITY CORPORATION CASE WESTERN RESERVE UNIVERSITY CORPORATION Organization address address: EUCLID AVENUE 10900 city: CLEVELAND OHIO postcode: 44106 7037 website: www.case.edu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (CLEVELAND OHIO)	participant	727˙787.00
6	AELIX THERAPEUTICS SL AELIX THERAPEUTICS SL Organization address address: CALLE BALDIRI REIXAC, 4-8 city: BARCELONA postcode: 8028 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	534˙978.00
7	FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA Organization address address: C ROSSELLO 132 PLANTA 05 city: BARCELONA postcode: 8036 website: www.isglobal.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	448˙021.00
8	CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER Organization address address: CALLE ROSSELLO 149 PUERTA BJS city: BARCELONA postcode: 8036 website: http://www.idibaps.org/en_index.html contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	351˙762.00
9	ASPHALION SL ASPHALION SL Organization address address: CALLE TARRAGONA, NUMEROS 151-157, PLANTA 10, BLOQU city: BARCELONA postcode: 8014 website: www.asphalion.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	316˙187.00
10	PROJECTE DELS NOMS - HISPANOSIDA ASOCIACION PROJECTE DELS NOMS - HISPANOSIDA ASOCIACION Organization address address: COMTE BORRELL 164 166 BAIXOS city: BARCELONA postcode: 8015 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	236˙737.00
11	VEDANTA BIOSCIENCES INC VEDANTA BIOSCIENCES INC Organization address address: CORPORATION TRUST CENTER 1209 ORANGE STREET city: WILMINGTON postcode: 19801 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (WILMINGTON)	participant	172˙493.00

Map

Project objective

The HIV/AIDS pandemic continues to be one of the major health challenges ever faced by mankind. Far from being resolved, HIV is soaring in Eastern Europe (60% increase in new infections and 27% increase in deaths since 2010) and other regions of the world despite increasing access to antiretroviral treatment. There is emerging evidence that the human microbiome impacts some of the most important clinical aspects of HIV-1 infection, including immune disorders, chronic inflammation and accelerated aging. Work in other viral diseases and cancer immunotherapy suggest a critical role of the human microbiome also in the outcome of immune therapeutic interventions in HIV-1 infection. The MISTRAL project brings together a team of world-class HIV and microbiome researchers and SMEs with ideal complementary knowledge and expertise. This team will work to discover and validate novel gut microbiome biomarkers to inform rationally-designed, mechanistically-driven interventions on the gut microbiome to mitigate HIV-1 acquisition, systemic inflammation, chronic clinical complications, antimicrobial drug resistance, and boost the efficacy of HIV cure immunotherapies. Integrated and curated large microbiome and host datasets generated during the execution of the project will be made public through a freely accessible, specifically-dedicated web-based repository. Biomarker discoveries will be incorporated into a cloud-based software tool that will automate microbiome analyses and interpretations, thus streamlining patient stratification for clinical and research purposes. If successful, MISTRAL will benefit millions of human beings living with, or at risk of acquiring HIV-1 infection, and will produce novel concepts and technical innovations applicable to other human diseases. By doing that, MISTRAL will help to unlock the full clinical potential of the human microbiome to stratify patient outcomes and will irreversibly bring microbiome science closer to clinical practice.

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The information about "MISTRAL" are provided by the European Opendata Portal: CORDIS opendata.

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