Opendata, web and dolomites

ExpoBiome SIGNED

Deciphering the impact of exposures from the gut microbiome-derived molecular complex in human health and disease

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 ExpoBiome project word cloud

Explore the words cloud of the ExpoBiome project. It provides you a very rough idea of what is the project "ExpoBiome" about.

therapeutic    acids    omic    outcomes    fasting    unknown    causal    time    characterised    base    biomarker    perform    immunophenotypes    neurodegenerative    immune    map    genes    prior    pd    diseases    physiology    ecosystem    inflammatory    collected    comprehensively    integrate    effector    contributes    samples    compounds    gut    first    track    health    models    ra    model    peptides    expobiome    levels    patients    relationships    rheumatoid    microbial    microbiome    screened    eluded    poly    functional    insights    inflammation    mechanistic    molecules    basis    metabolites    chip    diagnosed    validate    gap    generate    quantitative    intervention    personalised    limiting    constituents    humix    systematic    learning    functions    molecular    data    diagnostic    comprising    host    resolution    chronic    parkinson    contextualised    signature    machine    clinical    treatment    autoimmune    microbes    newly    human    nucleic    anti    combination    healthy    predict    arthritis    proteins    elucidation    disease    interactions    individuals   

Project "ExpoBiome" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE DU LUXEMBOURG 

Organization address
address: 2 AVENUE DE L'UNIVERSITE
city: ESCH-SUR-ALZETTE
postcode: 4365
website: http://wwwen.uni.lu

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Luxembourg [LU]
 Total cost 1˙998˙620 €
 EC max contribution 1˙998˙620 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-05-01   to  2025-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DU LUXEMBOURG LU (ESCH-SUR-ALZETTE) coordinator 1˙998˙620.00

Map

 Project objective

The human gut microbiome is a complex ecosystem, which contributes essential functions to human physiology. Changes to the microbiome are associated with several chronic diseases characterised by inflammation, including neurodegenerative and autoimmune diseases. Microbiome-derived effector molecules comprising nucleic acids, (poly)peptides and metabolites are present at high levels in the gut but have so far eluded systematic study. This gap in knowledge is limiting mechanistic understanding of the microbiome’s functional impact on chronic diseases such as Parkinson’s disease (PD) and rheumatoid arthritis (RA). Here, I will for the first time integrate a combination of advanced high-resolution methodologies to comprehensively identify the constituents of this molecular complex and their impact on the human immune system. First, I will perform a quantitative, integrated multi-omic analysis on microbiome samples collected from healthy individuals and patients with newly diagnosed PD or RA. I will integrate and analyse the data using a newly developed knowledge base. Using contextualised prior knowledge (ExpoBiome Map) and machine learning methods, I will identify microbial molecules associated with condition-specific immunophenotypes. Second, I will validate and track the biomarker signature during a model clinical intervention (therapeutic fasting) to predict treatment outcomes. Third, microbes and molecules will be screened in personalised HuMiX gut-on-chip models to identify novel anti-inflammatory compounds. By providing mechanistic insights into the molecular basis of human-microbiome interactions, the project will generate essential new knowledge about causal relationships between the gut microbiome and the immune system in health and disease. By facilitating the elucidation of currently unknown microbiome-derived molecules, it will identify new genes, proteins, metabolites and host pathways for the development of future diagnostic and therapeutic applications.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "EXPOBIOME" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "EXPOBIOME" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

KineTic (2020)

New Reagents for Quantifying the Routing and Kinetics of T-cell Activation

Read More  

NEUTRAMENTH (2018)

A redox-neutral process for the cost-efficient and environmentally friendly production of Menthol

Read More  

OSIRIS (2020)

Automatic measurement of speech understanding using EEG

Read More