Opendata, web and dolomites

NEMABOX SIGNED

Deciphering the cyst nematode parasitic program by uncovering how their virulence is orchestrated

Total Cost €

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EC-Contrib. €

0

Partnership

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 NEMABOX project word cloud

Explore the words cloud of the NEMABOX project. It provides you a very rough idea of what is the project "NEMABOX" about.

orchestrated    recognize    signatures    independent    fungal    breadth    alone    species    sub    nematodes    first    reader    gained    prohibit    dna    puzzle    solutions    fellowship    tomato    horizon2020    vivo    interactions    genetic    virulence    discovery    nematode    sustainable    academic    ventral    termed    explore    plant    threaten    cyst    pests    effort    proteins    gland    picture    question    career    level    pair    80    jigsaw    effector    box    parasitic    regulation    food    basis    spatio    mechanisms    dog    line    effectors    regulations    base    experiences    parasitism    possibility    complete    molecular    regulatory    temporal    inject    conserved    tangible    holistic    security    opens    dorsal    either    group    view    nematicides    potato    virulent    unified    glands    times    motif    drive    losses    area    readers    crop    biotechnological    launch    successful    corresponding    six    completion    pathogens    coding    transcription    primarily    hundreds   

Project "NEMABOX" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 212˙933.00

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 Project objective

Plant parasitic nematodes represent a significant group of plant pathogens that threaten current and future food security. Among them, the cyst nematodes target some of the most important crop species (tomato, potato) and cause up to 80% losses. European regulations prohibit the future use of many effective nematicides. We must improve our understanding of the virulence of the cyst nematodes to identify new targets for a sustainable biotechnological control of these pests. Here, I will use my experiences gained on plant-fungal interactions to address a major question in plant-nematode interactions: how is plant-parasitism orchestrated at the molecular level? To be virulent, cyst nematodes must inject “effector” proteins into the plant. These effectors are primarily produced in either the nematode’s dorsal or sub-ventral glands. Hundreds of these dorsal gland effectors are unified by a six base-pair non coding DNA motif, termed the “DOG box”. In a recent effort, a transcription factor that can recognize the DOG-box was identified, termed the “DOG box reader”. This discovery is the first tangible insight into the regulation of plant-nematode parasitism and opens the possibility to explore a new area of research. However, I recognize that the DOG box and its corresponding reader are only one part of the jigsaw puzzle. To complete the picture, in depth and breadth, I need to know: How does the DOG box reader work in vivo, and does it work alone? What are the genetic signatures and readers of other glands and at other times? To what extent are regulatory mechanisms conserved between cyst nematode species? I expect that successful completion of this fellowship will launch my independent academic career, drive forward the state-of the-art with a holistic “spatio-temporal” view of how plant-nematode parasitism is orchestrated at the molecular level, and provide a basis to explore sustainable solutions for improved food security, in line with the Horizon2020 programme.

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The information about "NEMABOX" are provided by the European Opendata Portal: CORDIS opendata.

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