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ChiCC SIGNED

Chirality via Cross-Coupling: New Asymmetric C-C Bond Formations Driven by Atom and Step Economy

Total Cost €

0

EC-Contrib. €

0

Partnership

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 ChiCC project word cloud

Explore the words cloud of the ChiCC project. It provides you a very rough idea of what is the project "ChiCC" about.

halides    philosophy    organo    desirable    structures    reaction    economy    chiral    bond    urgent    platforms    efficient    economical    erc    alkenes    compounds    actually    privileged    decreased    bonds    molecule    reactions    blocks    approximately    3d    predominantly    palladium    preliminary    building    enantiospecific    decades    complexity    circumvent    multiple    ideals    regio    exert    feedstock    drugs    small    mainstays    aryl    asymmetric    combined    concession    couplings    enantiomers    libraries    waste    industry    pharmaceutical    catalysed    80    usually    detracting    fulfil    made    absolute    planar    marketed    nucleophiles    suited    over    atom    world    discovery    selling    broad    consequently    holds    2d    stereocontrol    pseudo    relative    prototype    despite    single    coupling    stereochemistry    suzuki    cross    minimising    enantioselective    time    tremendous    prepare    settings    precursors    catalyst    modern    formations    thereby    family    drug    esp    surprisingly    activation    catalysis    effort    60   

Project "ChiCC" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF LIVERPOOL 

Organization address
address: BROWNLOW HILL 765 FOUNDATION BUILDING
city: LIVERPOOL
postcode: L69 7ZX
website: www.liverpool.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙999˙890 €
 EC max contribution 1˙999˙890 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-06-01   to  2025-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF LIVERPOOL UK (LIVERPOOL) coordinator 1˙999˙890.00

Map

 Project objective

Over 60% of the world’s top selling small molecule drug compounds are chiral and, of these, approximately 80% are marketed as single enantiomers. Surprisingly, and despite the tremendous advances made in catalysis over the past several decades, the average “chiral complexity” of drug discovery libraries has actually decreased, while, at the same time the “chiral complexity” of marketed drugs has increased. Consequently, there is now an urgent need to provide efficient processes that access directly privileged chiral “3D” building blocks. It is our philosophy that catalysis holds the key here and new processes should be based upon atom and step economical platforms that exert control over both absolute and relative stereochemistry. Palladium catalysed cross-coupling reactions of aryl (pseudo)halides with organo-nucleophiles (esp. the Suzuki coupling) have become mainstays of the pharmaceutical industry. Here, multiple “concession” steps are usually required to prepare the reaction partners, thereby detracting from atom and step economy. Further, these processes predominantly provide planar “2D” structures and are not well suited to the production of chiral “3D” building blocks. Consequently, methods that allow feedstock precursors (e.g. alkenes and aryl C-H bonds) to be combined directly in enantioselective or enantiospecific C-C bond formations are highly desirable. Cross-couplings of this type would circumvent “concession” steps, thereby minimising cost, effort and waste; however, such processes are highly challenging because of issues associated with regio- and stereocontrol. Recently, we developed prototype catalyst systems that can address this. In the proposed ERC project, these exciting preliminary results will be developed into a wider family of processes where asymmetric C-C bond formations are achieved directly by C-H activation. The new methods, which fulfil modern reaction ideals of atom and step economy, will likely find broad use in applied settings.

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