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AlzheimersInAction SIGNED

AlzheimersInAction: A multi-disciplinary approach to determine the cellular and molecular mechanisms underlying the inflammatory response to amyloid-β in Alzheimer’s disease.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 AlzheimersInAction project word cloud

Explore the words cloud of the AlzheimersInAction project. It provides you a very rough idea of what is the project "AlzheimersInAction" about.

visibility    cell    slow    families    underlying    synaptic    therapeutic    stages    fill    outputs    health    activation    progression    genetics    citizens    dementia    action    immune    nature    disease    alarming    difficult    fold    urgent    capturing    behavioural    computational    drug    onset    downstream    parallel    mechanisms    overproduction    cutting    drosophila    time    delay    made    beta    techniques    cure    neuronal    promoter    living    occurring    molecular    causes    overcome    develops    electrophysiology    completion    actually    lapse    pathogenesis    forms    patients    devastation    biological    critical    generates    diseases    comorbid    difficulties    imaging    interventions    disciplinary    cellular    enormous    treatments    neurological    brain    leads    biology    rapid    symptoms    absence    neurobiological    edge    lack    economy    gaps    powerful    rate    million    damage    pathologies    alzheimer    difficulty    inflammatory    ad    alzheimersinaction    output    flies    versatile    amyloid    combines    cells    predicted   

Project "AlzheimersInAction" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF EDINBURGH 

Organization address
address: OLD COLLEGE, SOUTH BRIDGE
city: EDINBURGH
postcode: EH8 9YL
website: www.ed.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 224˙933 €
 EC max contribution 224˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2021
 Duration (year-month-day) from 2021-09-01   to  2023-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EDINBURGH UK (EDINBURGH) coordinator 224˙933.00

Map

Leaflet | Map data © OpenStreetMap contributors, CC-BY-SA, Imagery © Mapbox

 Project objective

In addition to devastation for the patients and their families, Alzheimer’s disease (AD) generates enormous costs for the wider European economy and is an urgent health priority. There are currently no drug treatments that can cure AD or other common forms of dementia. This absence of therapeutic interventions comes from a lack of understanding about the biological changes that cause most neurological diseases. It is critical to fill in the gaps in our understanding of what biological changes are occurring during the early stages of AD in order to develop treatments that could slow progression or delay the onset of AD. The comorbid nature of this disease and the difficulty of capturing neurobiological processes in action in real time have made it very difficult to determine what changes in the AD brain actually cause the synaptic and neuronal damage that leads to behavioural symptoms. To overcome these difficulties, I propose a multi-disciplinary approach that combines and develops cutting-edge techniques in Drosophila cell biology, molecular biology, time-lapse imaging, computational modelling, and electrophysiology in parallel with exploitation of the powerful molecular genetics, versatile promoter systems and rapid development of flies. Specifically, throughout AlzheimersInAction I will use these techniques to develop an in depth understanding of how an overproduction of amyloid-β causes downstream pathologies, and how activation of the immune cells during AD causes disease pathogenesis. By the completion of this project we will have a greater understanding of the cellular and molecular mechanisms underlying the inflammatory response to Aβ in Alzheimer’s disease. With 10.5 million EU citizens currently living with dementia, and this value predicted to increase at an alarming rate of 2-fold every 20 years, the outputs from AlzheimersInAction will contribute to the research output, visibility, and economy of Europe.

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The information about "ALZHEIMERSINACTION" are provided by the European Opendata Portal: CORDIS opendata.

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