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PyroSuL SIGNED

Pyrophosphate Surrogates with Low polarity as part of glycosyltransferase ligands

Total Cost €

EC-Contrib. €

Partnership

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PyroSuL project word cloud

Explore the words cloud of the PyroSuL project. It provides you a very rough idea of what is the project "PyroSuL" about.

polarity affinities affinity nucleoside cellular moiety polar spectroscopic zone carbohydrate synthetically substrate final firstly mass acting inhibitors incorporated blocks good nuclear techniques vivo surrogates biological bottleneck glycosyltransferase pyrosul spectrometry magnetic synthetic employed protein membrane building explored computational ligands spectrometric derivatives interaction membranes pyrophosphate bearing resonance permeability mimic permeate recognition structure showing obtaining compounds

Project "PyroSuL" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITY OF EAST ANGLIA Organization address address: EARLHAM ROAD city: NORWICH postcode: NR4 7TJ website: http://www.uea.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	212˙933 €
EC max contribution	212˙933 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2019
Funding Scheme	MSCA-IF-EF-ST
Starting year	2021
Duration (year-month-day)	from 2021-01-01 to 2022-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITY OF EAST ANGLIA UNIVERSITY OF EAST ANGLIA Organization address address: EARLHAM ROAD city: NORWICH postcode: NR4 7TJ website: http://www.uea.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (NORWICH)	coordinator	212˙933.00

Map

Project objective

PyroSuL (Pyrophosphate Surrogates with Low polarity as part of glycosyltransferase ligands) is a project focused on the development of synthetic building blocks acting as surrogates for the pyrophosphate moiety in glycosyltransferase inhibitors. The final aim of this project is obtaining less polar ligands and inhibitors able to permeate across cellular membranes, which is the bottleneck for these inhibitors to have in vivo biological application. Through structure-based design, new surrogates will be explored. Interaction studies will be carried out through firstly computational approaches, and spectroscopic (nuclear magnetic resonance) and spectrometric (mass spectrometry) techniques will be employed. Surrogates showing promising affinity with the pyrophosphate recognition zone will be synthetically incorporated to substrate-like compounds, bearing a nucleoside and a carbohydrate or mimic. Final derivatives are supposed to show good protein affinities and membrane permeability properties.

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The information about "PYROSUL" are provided by the European Opendata Portal: CORDIS opendata.