BioMaGic SIGNED
Design of biomaterials with enzymatic logic gates
Total Cost €
0EC-Contrib. €
0Partnership
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0BioMaGic project word cloud
Explore the words cloud of the BioMaGic project. It provides you a very rough idea of what is the project "BioMaGic" about.
Project "BioMaGic" data sheet
The following table provides information about the project.
| Coordinator |
TECHNISCHE UNIVERSITEIT EINDHOVEN
Organization address contact info |
| Coordinator Country | Netherlands [NL] |
| Total cost | 253˙052 € |
| EC max contribution | 253˙052 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2019 |
| Funding Scheme | MSCA-IF-GF |
| Starting year | 2021 |
| Duration (year-month-day) | from 2021-07-01 to 2024-06-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | TECHNISCHE UNIVERSITEIT EINDHOVEN | NL (EINDHOVEN) | coordinator | 253˙052.00 |
| 2 | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | US (CAMBRIDGE) | partner | 0.00 |
Map
Project objective
The present proposal takes a novel approach to design biomaterials with enzymatic logic gates. By mimicking enzymatic biocatalytic cascades present in natural tissues, these biomaterials will be able to receive and process multiple biochemical signals, and logically elicit therapeutic outputs in response to specific combinations of input signals. This goal will be realized using enzymatically active hydrogel particles (Specific Objective (SO) 1) as building blocks that will be assembled into biomaterial coatings (SO 2) or three-dimensional constructs (SO 3), which can be applied to surfaces of currently available biomaterials or serve as autonomous implantable biomaterials, respectively. To illustrate the wide applicability of this biomaterial design strategy, two major clinical challenges are selected as target applications, i.e., tissue regeneration and bacterial infection. The fellowship will harness the existing experience of the researcher in (bio)materials science, and will add a new dimension to this expertise in terms of biochemical signaling and enzymatic reactions. To achieve this goal, the researcher will carry out the outgoing phase of this fellowship at Harvard University, and then return to Eindhoven University of Technology for the incoming phase. The envisioned activities described in the proposal will prepare the researcher to emerge from this fellowship with additional scientific competences and transferable skills, and to establish an expanded international network. The success in this project will introduce a new class of biomaterials with dynamic signaling capabilities to elicit logic-based therapeutic effects, which can impact virtually all fields in which biomaterials are used, contributing to the enhancement of EU healthcare and economic interests. Through BioMaGic, the researcher will initiate an independent line of research as the basis for establishing an academic faculty career at a European research university.
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The information about "BIOMAGIC" are provided by the European Opendata Portal: CORDIS opendata.