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BIOCYCLE SIGNED

BIOlogical therapy CYCLEs towards tailored, needs-driven, safer and cost-effective management of Crohn’s disease

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

BIOCYCLE project word cloud

Explore the words cloud of the BIOCYCLE project. It provides you a very rough idea of what is the project "BIOCYCLE" about.

chronic interruption alpha central primary reducing opinion clinical combination benefits regimens secondary of monoclonal tnf quantitative treatment helping biocycle calculate evolution safety immunosuppressant risks surveys administrated diseases generating efficacy qualitative idea critically outcomes decide parallel caregivers validated cycles alternating appraisal predictors intestinal tract basis readiness immune standard experimental disease centric proposes feasibility patients gastro mediated maintaining critical usa immunosuppressants innovative discussed crohn leaders shifting guidelines periods perform cd fits inflammatory treatments proven treating drugs data anti arms illness regimen 300 antibodies either healthcare gold patient

Project "BIOCYCLE" data sheet

The following table provides information about the project.

Coordinator	CENTRE HOSPITALIER UNIVERSITAIRE DE LIEGE Organization address address: Sart Tilman B35 city: LIEGE postcode: 4000 website: www.chuliege.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Belgium [BE]
Project website	http://biocycle-project.eu/
Total cost	5˙975˙589 €
EC max contribution	5˙975˙589 € (100%)
Programme	1. H2020-EU.3.1.3. (Treating and managing disease)
Code Call	H2020-PHC-2014-two-stage
Funding Scheme	RIA
Starting year	2015
Duration (year-month-day)	from 2015-04-01 to 2021-03-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	CENTRE HOSPITALIER UNIVERSITAIRE DE LIEGE CENTRE HOSPITALIER UNIVERSITAIRE DE LIEGE Organization address address: Sart Tilman B35 city: LIEGE postcode: 4000 website: www.chuliege.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (LIEGE)	coordinator	821˙100.00
2	GROUPE D'ETUDES THERAPEUTIQUES DES AFFECTIONS INFLAMMATOIRES DIGESTIVES ASSOCIATION GROUPE D'ETUDES THERAPEUTIQUES DES AFFECTIONS INFLAMMATOIRES DIGESTIVES ASSOCIATION Organization address address: 2 RUE AMBROISE PARE city: PARIS postcode: 75010 website: www.getaid.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	2˙217˙600.00
3	THE UNIVERSITY OF EDINBURGH THE UNIVERSITY OF EDINBURGH Organization address address: OLD COLLEGE, SOUTH BRIDGE city: EDINBURGH postcode: EH8 9YL website: www.ed.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (EDINBURGH)	participant	506˙017.00
4	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Organization address address: WELLINGTON SQUARE UNIVERSITY OFFICES city: OXFORD postcode: OX1 2JD website: www.ox.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (OXFORD)	participant	416˙435.00
5	SKANE LANS LANDSTING SKANE LANS LANDSTING Organization address address: . city: KRISTIANSTAD postcode: 291 89 website: www.skane.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (KRISTIANSTAD)	participant	352˙000.00
6	CHARITE - UNIVERSITAETSMEDIZIN BERLIN CHARITE - UNIVERSITAETSMEDIZIN BERLIN Organization address address: Chariteplatz 1 city: BERLIN postcode: 10117 website: www.charite.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BERLIN)	participant	321˙000.00
7	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Organization address address: RUE DE TOLBIAC 101 city: PARIS postcode: 75654 website: www.inserm.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	314˙271.00
8	IBDIM - IBD IN MOTION GMBH IBDIM - IBD IN MOTION GMBH Organization address address: UNGARGASSE 6/13 city: WIEN postcode: 1030 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	participant	239˙416.00
9	BRIDGE2HEALTH BRIDGE2HEALTH Organization address address: DOMAINE UNIVERSITAIRE DU BAT B 35 city: LIEGE postcode: 4000 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (LIEGE)	participant	189˙500.00
10	MEDICAL RESEARCH INFRASTRUCTURE DEVELOPMENT AND HEALTH SERVICES FUND BY THE SHEBA MEDICAL CENTER MEDICAL RESEARCH INFRASTRUCTURE DEVELOPMENT AND HEALTH SERVICES FUND BY THE SHEBA MEDICAL CENTER Organization address address: TEL HASHOMER SHEBA MEDICAL CENTER city: RAMAT GAN postcode: 52621 website: http://www.sheba.co.il contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (RAMAT GAN)	participant	165˙963.00
11	UNIVERSITE CATHOLIQUE DE LOUVAIN UNIVERSITE CATHOLIQUE DE LOUVAIN Organization address address: PLACE DE L UNIVERSITE 1 city: LOUVAIN LA NEUVE postcode: 1348 website: www.uclouvain.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (LOUVAIN LA NEUVE)	participant	122˙475.00
12	GOETEBORGS UNIVERSITET GOETEBORGS UNIVERSITET Organization address address: VASAPARKEN city: GOETEBORG postcode: 405 30 website: www.gu.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (GOETEBORG)	participant	121˙875.00
13	CROHN'S & COLITIS FOUNDATION OF AMERICA, INC. CROHN'S & COLITIS FOUNDATION OF AMERICA, INC. Organization address address: 733 THIRD ROAD SUITE 501 city: NEW YORK postcode: 10017 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (NEW YORK)	participant	114˙311.00
14	ASSOCIATION FRANCOIS AUPETIT ASSOCIATION FRANCOIS AUPETIT Organization address address: 32 RUE DE CAMBRAI city: PARIS postcode: 75019 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	73˙625.00

Map

Project objective

'The BIOCYCLE Project proposes to test and critically assess the benefits and risks of an innovative regimen for improving the treatment of Crohn’s disease (CD), a chronic immune-mediated inflammatory disease affecting the gastro-intestinal tract of an increasing number of patients. Currently, the combination of anti-TNFα monoclonal antibodies and immunosuppressants used without interruption is the gold standard for treating CD. However, long treatments are needed which raise safety concerns and costs. For maintaining the same level of efficacy while reducing risks and costs, the idea of BIOCYCLE is to use a regimen based on 'Treatment Cycles' characterized by alternating periods where both drugs are administrated and periods where only either anti-TNFα or immunosuppressant is used. The central part of the Project will be a large-scale controlled multi-centric clinical study including 300 patients in EU and USA to test the feasibility of shifting from drugs combination used without interruption (control) to Treatment Cycles (experimental arms). Primary and secondary objectives of the clinical study have already been validated for generating the best qualitative and quantitative data on clinical outcomes, predictors of disease evolution and costs. In parallel, the Project will calculate costs-of-illness associated with the different regimens and will perform surveys among patients, caregivers and healthcare systems representatives to assess their readiness to include/support Treatment Cycles in the clinical practice. This will be the basis of a critical appraisal of Treatment Cycles and guidelines for helping caregivers to decide which treatment regimen best fits the specific needs of their patient. If proven, the benefits of Treatment Cycles for treating CD will be discussed with key-opinion leaders involved in the treatment of other immune-mediated inflammatory chronic diseases to support the evolution of disease-driven treatments towards needs-driven treatments.'

Deliverables

List of deliverables.
\"BIOCYCLE Scientific and financial progress report #2\"	Documents, reports	2020-04-09 08:09:28
Submission package	Documents, reports	2020-04-09 08:09:28
BIOCYCLE Website	Websites, patent fillings, videos etc.	2020-04-09 08:09:28

Take a look to the deliverables list in detail: detailed list of BIOCYCLE deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Corey A. Siegel, Kimberly D. Thompson, Danielle Walls, Jan Gollins, Anne Buisson, Alain Olympie, Laurent Beaugerie, Jean-Frederic Colombel, Edouard Louis Crohnâ€™s disease patientsâ€™ and gastroenterologistsâ€™ perspectives towards de-escalating inflammatory bowel disease therapy published pages: , ISSN: 1542-3565, DOI: 10.1016/j.cgh.2019.11.062	Clinical Gastroenterology and Hepatology	2020-04-09
2020	Edouard Louis Tailoring Biologic or Immunomodulator Treatment Withdrawal in Inflammatory Bowel Disease published pages: , ISSN: 2296-858X, DOI: 10.3389/fmed.2019.00302	Frontiers in Medicine 6	2020-04-09
2018	Nathalie Y Pauwen, Edouard Louis, Corey Siegel, Jean-Frederic Colombel, Jean Macq Integrated Care for Crohnâ€™s Disease: A Plea for the Development of Clinical Decision Support Systems published pages: 1499-1504, ISSN: 1873-9946, DOI: 10.1093/ecco-jcc/jjy128	Journal of Crohn\'s and Colitis 12/12	2020-04-09
2018	Edouard Louis Stopping Biologics in IBDâ€”What Is the Evidence? published pages: , ISSN: 1078-0998, DOI: 10.1093/ibd/izx098	Inflammatory Bowel Diseases	2020-04-09
2016	Jack Satsangi, Olivier Kitten, Marcela Chavez, Rahul Kalla, Nadege Prel, Marie-Alice Meuwis, Stephanie Scott, Illaria Bonetti, Nicholas T. Ventham, Edouard Louis How to Apply for and Secure EU Funding for Collaborative IBD Research Projects published pages: 363-370, ISSN: 1873-9946, DOI: 10.1093/ecco-jcc/jjv237	Journal of Crohn\'s and Colitis 10/3	2020-04-09
2017	Glen Doherty, Konstantinos H Katsanos, Johan Burisch, Matthieu Allez, Konstantinos Papamichael, Andreas Stallmach, Ren Mao, Ingrid Prytz Berset, Javier P Gisbert, Shaji Sebastian, JarosÅ‚aw KierkuÅ›, Loris Lopetuso, Edyta Szymanska, Edouard Louis European Crohnâ€™s and Colitis Organisation Topical Review on Treatment Withdrawal [â€˜Exit Strategiesâ€™] in Inflammatory Bowel Disease published pages: 17-31, ISSN: 1873-9946, DOI: 10.1093/ecco-jcc/jjx101	Journal of Crohn\'s and Colitis 12/1	2020-04-09
2015	Joana Torres, Ray K. Boyapati, Nicholas A. Kennedy, Edouard Louis, Jean-FrÃ©dÃ©ric Colombel, Jack Satsangi Systematic Review of Effects of Withdrawal of Immunomodulators or Biologic Agents From Patients With Inflammatory Bowel Disease published pages: 1716-1730, ISSN: 0016-5085, DOI: 10.1053/j.gastro.2015.08.055	Gastroenterology 149/7	2020-04-09

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The information about "BIOCYCLE" are provided by the European Opendata Portal: CORDIS opendata.