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ENSAT-HT SIGNED

Application of omics-based strategies for improved diagnosis and treatment of endocrine hypertension

Total Cost €

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EC-Contrib. €

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Partnership

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Outcomes and
results

ENSAT-HT project word cloud

Explore the words cloud of the ENSAT-HT project. It provides you a very rough idea of what is the project "ENSAT-HT" about.

adrenal risk increments diseases syndrome exists 62 population data complications 49 biomarkers profiling attributable prevention curative diminished groups genetics benefit efficient therapy ppgl phenome pressure heart cerebrovascular metabolomics screening hypertension underlying aldosteronism forms hypertensive million cluster optimal hormones cardiovascular cs group paraganglioma treatment hypertensives regulation disease pa pheochromocytoma causes 45 deaths endocrine stratified bioinformatics functional therapeutic worldwide validated profiles life annotations quality stratifying identification metabolic arsenal primary health patients small sub blood throughput omics stratification integrating phenotypes ing thirds responsible ischemic detection cushing preclinical promotion secondary personalised genomics disorders arterial

Project "ENSAT-HT" data sheet

The following table provides information about the project.

Coordinator	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Organization address address: RUE DE TOLBIAC 101 city: PARIS postcode: 75654 website: www.inserm.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Project website	http://www.ensat-ht.eu/index.php
Total cost	8˙440˙635 €
EC max contribution	7˙607˙337 € (90%)
Programme	1. H2020-EU.3.1.2. (Preventing disease)
Code Call	H2020-PHC-2014-two-stage
Funding Scheme	RIA
Starting year	2015
Duration (year-month-day)	from 2015-05-01 to 2020-04-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Organization address address: RUE DE TOLBIAC 101 city: PARIS postcode: 75654 website: www.inserm.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	coordinator	1˙445˙501.00
2	UNIVERSITY OF DUNDEE UNIVERSITY OF DUNDEE Organization address address: Nethergate city: DUNDEE postcode: DD1 4HN website: www.dundee.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (DUNDEE)	participant	1˙011˙755.00
3	ASSISTANCE PUBLIQUE HOPITAUX DE PARIS ASSISTANCE PUBLIQUE HOPITAUX DE PARIS Organization address address: 3 AVENUE VICTORIA city: PARIS postcode: 75000 website: http://www.aphp.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	988˙500.00
4	UNIVERSITY OF GLASGOW UNIVERSITY OF GLASGOW Organization address address: UNIVERSITY AVENUE city: GLASGOW postcode: G12 8QQ website: www.gla.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (GLASGOW)	participant	766˙380.00
5	UNIVERSITA DEGLI STUDI DI PADOVA UNIVERSITA DEGLI STUDI DI PADOVA Organization address address: VIA 8 FEBBRAIO 2 city: PADOVA postcode: 35122 website: www.unipd.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (PADOVA)	participant	734˙500.00
6	STICHTING KATHOLIEKE UNIVERSITEIT STICHTING KATHOLIEKE UNIVERSITEIT Organization address address: GEERT GROOTEPLEIN NOORD 9 city: NIJMEGEN postcode: 6525 EZ website: www.radboudumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (NIJMEGEN)	participant	660˙653.00
7	TECHNISCHE UNIVERSITAET DRESDEN TECHNISCHE UNIVERSITAET DRESDEN Organization address address: HELMHOLTZSTRASSE 10 city: DRESDEN postcode: 1069 website: http://www.tu-dresden.de/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (DRESDEN)	participant	446˙459.00
8	INSERM TRANSFERT SA INSERM TRANSFERT SA Organization address address: RUE WATT 7 city: PARIS postcode: 75013 website: www.inserm-transfert.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	424˙375.00
9	HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH Organization address address: INGOLSTADTER LANDSTRASSE 1 city: NEUHERBERG postcode: 85764 website: www.helmholtz-muenchen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (NEUHERBERG)	participant	404˙200.00
10	THE UNIVERSITY OF BIRMINGHAM THE UNIVERSITY OF BIRMINGHAM Organization address address: Edgbaston city: BIRMINGHAM postcode: B15 2TT website: www.bham.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (BIRMINGHAM)	participant	309˙326.00
11	UNIVERSITA DEGLI STUDI DI TORINO UNIVERSITA DEGLI STUDI DI TORINO Organization address address: VIA GIUSEPPE VERDI 8 city: TORINO postcode: 10124 website: www.unito.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (TORINO)	participant	285˙969.00
12	LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN Organization address address: GESCHWISTER SCHOLL PLATZ 1 city: MUENCHEN postcode: 80539 website: www.uni-muenchen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	participant	129˙719.00
13	UNIVERSITY OF MELBOURNE UNIVERSITY OF MELBOURNE Organization address address: PARKVILLEOFFICE OF THE VICE CHANCELLOR city: MELBOURNE postcode: 3010 website: www.unimelb.edu.au contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AU (MELBOURNE)	participant	0.00

Map

Project objective

Arterial hypertension affects up to 45% of the general population and is responsible for 7.1 million deaths per year worldwide. Although a large therapeutic arsenal exists, blood pressure control is sub-optimal in up to two thirds of patients. Yet, even small increments in blood pressure are associated with increased cardiovascular risk, with 62% of cerebrovascular disease and 49% of ischemic heart disease being attributable to hypertension. Detection of secondary forms of hypertension is key to targeted management of the underlying disease and prevention of cardiovascular complications. Endocrine forms of hypertension represent major targets for stratified approaches of health promotion. They include a group of adrenal disorders resulting in increased production of hormones affecting blood pressure regulation: primary aldosteronism (PA), pheochromocytoma/functional paraganglioma (PPGL) and Cushing’s syndrome (CS). These diseases are associated with increased cardiovascular and metabolic risk and with diminished quality of life. This project will develop and evaluate an omics-based stratified health promotion program for patients with endocrine forms of hypertension. We will define specific omics profiles for patients with PA, PPGL and CS by integrating high throughput genetics, genomics and metabolomics data with phenome annotations through bioinformatics modelling. Established profiles will be validated as stratification biomarkers and applied to the screening of referred hypertensive patients for both stratifying primary forms of hypertension for effective and cost efficient therapy as well as improving identification of endocrine causes for curative treatment and prevention of cardiovascular and metabolic complications. Omics-based profiling should allow identification of patients with preclinical phenotypes along with those hypertensives that cluster into specific endocrine groups who may benefit from personalised treatment.

Deliverables

List of deliverables.
Establishment of project web site	Websites, patent fillings, videos etc.	2020-04-22 09:53:28

Take a look to the deliverables list in detail: detailed list of ENSAT-HT deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2017	Wiebke Arlt, Katharina Lang, Alice J. Sitch, Anna S. Dietz, Yara Rhayem, Irina Bancos, Annette Feuchtinger, Vasileios Chortis, Lorna C. Gilligan, Philippe Ludwig, Anna Riester, Evelyn Asbach, Beverly A. Hughes, Donna M. Oâ€™Neil, Martin Bidlingmaier, Jeremy W. Tomlinson, Zaki K. Hassan-Smith, D. Aled Rees, Christian Adolf, Stefanie Hahner, Marcus Quinkler, Tanja Dekkers, Jaap Deinum, Michael Biehl Steroid metabolome analysis reveals prevalent glucocorticoid excess in primary aldosteronism published pages: , ISSN: 2379-3708, DOI: 10.1172/jci.insight.93136	JCI Insight 2/8	2020-04-22
2017	Graeme Eisenhofer, Mirko Peitzsch, Denise Kaden, Katharina Langton, Christina Pamporaki, Jimmy Masjkur, George Tsatsaronis, Anastasios Mangelis, Tracy A. Williams, Martin Reincke, Jacques W.M. Lenders, Stefan R. Bornstein Reference intervals for plasma concentrations of adrenal steroids measured by LC-MS/MS: Impact of gender, age, oral contraceptives, body mass index and blood pressure status published pages: 115-124, ISSN: 0009-8981, DOI: 10.1016/j.cca.2017.05.002	Clinica Chimica Acta 470	2020-04-22
2016	Graeme Eisenhofer, Mirko Peitzsch, Brett C. McWhinney Impact of LC-MS/MS on the laboratory diagnosis of catecholamine-producing tumors published pages: 106-116, ISSN: 0165-9936, DOI: 10.1016/j.trac.2016.01.027	TrAC Trends in Analytical Chemistry 84	2020-04-22
2017	Stacy Robertson, Louise A. Diver, Samantha Alvarez-Madrazo, Craig Livie, Ayesha Ejaz, Robert Fraser, John M. Connell, Scott M. MacKenzie, Eleanor Davies Regulation of Corticosteroidogenic Genes by MicroRNAs published pages: 1-11, ISSN: 1687-8337, DOI: 10.1155/2017/2021903	International Journal of Endocrinology 2017	2020-04-22
2017	Rao, Dipti; Peitzsch, Mirko; Prejbisz, Aleksander; Hanus, Katarzyna; Fassnacht, Martin; Beuschlein, Felix; Brugger, Christina; Fliedner, Stephanie; Langton, Katharina; Pamporaki, Christina; Gudziol, Volker; Stell, Anthony; Januszewicz, Andrzej; Timmers, Henri J L M; Lenders, Jacques W M; Eisenhofer, Graeme Plasma methoxytyramine: clinical utility with metanephrines for diagnosis of pheochromocytoma and paraganglioma published pages: 103-113, ISSN: 0804-4643, DOI: 10.5167/uzh-138824	European Journal of Endocrinology 2	2020-04-22
2018	Graeme Eisenhofer, Jimmy Masjkur, Mirko Peitzsch, Guido Di Dalmazi, Martin Bidlingmaier, Matthias GrÃ¼ber, Julia Fazel, Andrea Osswald, Felix Beuschlein, Martin Reincke Plasma Steroid Metabolome Profiling for Diagnosis and Subtyping Patients with Cushing Syndrome published pages: 586-596, ISSN: 0009-9147, DOI: 10.1373/clinchem.2017.282582	Clinical Chemistry 64/3	2020-04-22
2015	Tracy Ann Williams, Mirko Peitzsch, Anna S. Dietz, Tanja Dekkers, Martin Bidlingmaier, Anna Riester, Marcus Treitl, Yara Rhayem, Felix Beuschlein, Jacques W.M. Lenders, Jaap Deinum, Graeme Eisenhofer, Martin Reincke Genotype-Specific Steroid Profiles Associated With Aldosterone-Producing AdenomasNovelty and Significance published pages: 139-145, ISSN: 0194-911X, DOI: 10.1161/HYPERTENSIONAHA.115.06186	Hypertension 67/1	2020-04-22
2018	Thomas Nind, James Galloway, Gordon McAllister, Donald Scobbie, Wilfred Bonney, Christopher Hall, Leandro Tramma, Parminder Reel, Martin Groves, Philip Appleby, Alex Doney, Bruce Guthrie, Emily Jefferson The Research Data Management Platform (RDMP): A novel, process driven, open-source tool for the management of longitudinal cohorts of clinical data published pages: P 115-124, ISSN: 2047-217X, DOI: 10.1093/gigascience/giy060	GigaScience	2020-04-22
2015	M. Moors, T. Williams, J. Deinum, G. Eisenhofer, M. Reincke, J. Lenders Steroid Hormone Production in Patients with Aldosterone Producing Adenomas published pages: 967-972, ISSN: 0018-5043, DOI: 10.1055/s-0035-1565225	Hormone and Metabolic Research 47/13	2020-04-22
2018	Fabio L. Fernandes-Rosa, Georgios Daniil, Ian J. Orozco, Corinna GÃ¶ppner, Rami El Zein, Vandana Jain, Sheerazed Boulkroun, Xavier Jeunemaitre, Laurence Amar, HervÃ© Lefebvre, Thomas Schwarzmayr, Tim M. Strom, Thomas J. Jentsch, Maria-Christina Zennaro A gain-of-function mutation in the CLCN2 chloride channel gene causes primary aldosteronism published pages: 355-361, ISSN: 1061-4036, DOI: 10.1038/s41588-018-0053-8	Nature Genetics 50/3	2020-04-22
2016	Nelly Burnichon, Alexandre Buffet, Anne-Paule Gimenez-Roqueplo Pheochromocytoma and paraganglioma published pages: 5-10, ISSN: 1040-8746, DOI: 10.1097/CCO.0000000000000249	Current Opinion in Oncology 28/1	2020-04-22
2016	G. Eisenhofer, T. Dekkers, M. Peitzsch, A. S. Dietz, M. Bidlingmaier, M. Treitl, T. A. Williams, S. R. Bornstein, M. Haase, L. C. Rump, H. S. Willenberg, F. Beuschlein, J. Deinum, J. W. M. Lenders, M. Reincke Mass Spectrometry-Based Adrenal and Peripheral Venous Steroid Profiling for Subtyping Primary Aldosteronism published pages: 514-524, ISSN: 0009-9147, DOI: 10.1373/clinchem.2015.251199	Clinical Chemistry 62/3	2020-04-22
2016	Rodrigo A. Toledo, Nelly Burnichon, Alberto Cascon, Diana E. Benn, Jean-Pierre Bayley, Jenny Welander, Carli M. Tops, Helen Firth, Trish Dwight, Tonino Ercolino, Massimo Mannelli, Giuseppe Opocher, Roderick Clifton-Bligh, Oliver Gimm, Eamonn R. Maher, Mercedes Robledo, Anne-Paule Gimenez-Roqueplo, Patricia L. M. Dahia Consensus Statement on next-generation-sequencing-based diagnostic testing of hereditary phaeochromocytomas and paragangliomas published pages: , ISSN: 1759-5029, DOI: 10.1038/nrendo.2016.185	Nature Reviews Endocrinology	2020-04-22
2018	Fabio L. Fernandes-Rosa, Georgios Daniil, Ian J. Orozco, Corinna GÃ¶ppner, Rami El Zein, Vandana Jain, Sheerazed Boulkroun, Xavier Jeunemaitre, Laurence Amar, HervÃ© Lefebvre, Thomas Schwarzmayr, Tim M. Strom, Thomas J. Jentsch, Maria-Christina Zennaro A gain-of-function mutation in the CLCN2 chloride channel gene causes primary aldosteronism published pages: 355-361, ISSN: 1061-4036, DOI: 10.1038/s41588-018-0053-8	Nature Genetics 50/3	2020-04-22

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