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OPERAM SIGNED

OPtimising thERapy to prevent Avoidable hospital admissions in the Multimorbid elderly

Total Cost €

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EC-Contrib. €

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Partnership

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Outcomes and
results

OPERAM project word cloud

Explore the words cloud of the OPERAM project. It provides you a very rough idea of what is the project "OPERAM" about.

trial prescription primary outcomes multimorbid excluded practical compliance uncertain limits solutions personalised structured assisted meta stopp life nmas causes medications bleeding criteria userfriendly investigators software falls intervention detect inappropriate ultimately trials unnecessary optimal pharmacotherapy multimorbidity start indicated enhanced multiple fractures preferences adults multicentre perform hospital nma polypharmacy ge aged care systematic effectiveness population underuse 75 discontinuation pharmacological guidelines 1900 prescribing interventions safe most therapy admissions patient diseases centred customised chronic elderly patients older network 30 operam reducing randomised healthcare safest reduce optimise drug health clinical poor preventable utilisation reduces isolation optimisation quality safety

Project "OPERAM" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITAET BERN Organization address address: HOCHSCHULSTRASSE 6 city: BERN postcode: 3012 website: http://www.unibe.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Switzerland [CH]
Project website	http://www.operam-2020.eu
Total cost	3˙930˙277 €
EC max contribution	3˙735˙608 € (95%)
Programme	1. H2020-EU.3.1.3. (Treating and managing disease)
Code Call	H2020-PHC-2014-two-stage
Funding Scheme	RIA
Starting year	2015
Duration (year-month-day)	from 2015-05-01 to 2020-04-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITAET BERN UNIVERSITAET BERN Organization address address: HOCHSCHULSTRASSE 6 city: BERN postcode: 3012 website: http://www.unibe.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (BERN)	coordinator	71˙245.00
2	UNIVERSITE CATHOLIQUE DE LOUVAIN UNIVERSITE CATHOLIQUE DE LOUVAIN Organization address address: PLACE DE L UNIVERSITE 1 city: LOUVAIN LA NEUVE postcode: 1348 website: www.uclouvain.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (LOUVAIN LA NEUVE)	participant	1˙084˙375.00
3	UNIVERSITAIR MEDISCH CENTRUM UTRECHT UNIVERSITAIR MEDISCH CENTRUM UTRECHT Organization address address: HEIDELBERGLAAN 100 city: UTRECHT postcode: 3584 CX website: www.umcutrecht.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (UTRECHT)	participant	950˙398.00
4	UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK Organization address address: WESTERN ROAD city: Cork postcode: T12 YN60 website: www.ucc.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (Cork)	participant	878˙006.00
5	TP21 GMBH TP21 GMBH Organization address address: LUISENSTRASSE 14 city: BERLIN postcode: 10117 website: www.tp21.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BERLIN)	participant	269˙000.00
6	UNIVERSITEIT UTRECHT UNIVERSITEIT UTRECHT Organization address address: HEIDELBERGLAAN 8 city: UTRECHT postcode: 3584 CS website: www.uu.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (UTRECHT)	participant	247˙460.00
7	PANEPISTIMIO IOANNINON PANEPISTIMIO IOANNINON Organization address address: PANEPISTEMIOYPOLE PANEPISTEMIO IOANNINON city: IOANNINA postcode: 45110 website: www.uoi.gr / www.rc.uoi.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (IOANNINA)	participant	185˙857.00
8	UNIVERSITA DEGLI STUDI GABRIELE D'ANNUNZIO DI CHIETI-PESCARA UNIVERSITA DEGLI STUDI GABRIELE D'ANNUNZIO DI CHIETI-PESCARA Organization address address: Via dei Vestini 31 city: CHIETI postcode: 66013 website: www.unich.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (CHIETI)	participant	49˙265.00
9	UNIVERSITAT BASEL UNIVERSITAT BASEL Organization address address: PETERSPLATZ 1 city: BASEL postcode: 4051 website: www.unibas.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (BASEL)	participant	0.00

Map

Project objective

Most older adults have multiple chronic diseases (multimorbidity) and multiple medications (polypharmacy). However, multimorbid patients are often excluded from clinical trials and most guidelines address diseases in isolation. Inappropriate drug prescription and poor drug compliance are common and contribute to up to 30% of hospital admissions. OPERAM investigators developed STOPP/START criteria to detect inappropriate drug use, both over- and underuse. Applying these criteria limits unnecessary polypharmacy and reduces underuse of indicated medications, but it remains uncertain whether systematic pharmacotherapy optimisation can improve clinical outcomes and reduce costs.We propose a multicentre randomised controlled trial to assess the impact of a userfriendly software-assisted intervention to optimise pharmacotherapy and to enhance compliance in 1900 multimorbid patients aged ≥75 years. Outcomes will include drug-related hospital admissions, health care utilisation, quality of life, patient preferences and cost-effectiveness. We will also perform several network meta-analyses (NMA) to provide new comparative evidence on the most effective and safest pharmacological and non-pharmacological interventions to reduce common causes of preventable hospital admissions (e.g. falls, fractures, bleeding). Therapy optimisation in the multimorbid elderly, enhanced compliance and discontinuation of less effective interventions have the potential to improve clinical, quality of life and safety outcomes, while reducing costs. We will provide a structured method with practical software solutions for optimal prescribing and new comparative evidence from NMAs for addressing multimorbidity and polypharmacy by means of customised, patient-centred guidelines. OPERAM ultimately aims at better healthcare delivery in primary and hospital care, based on effective, safe, personalised and cost-effective interventions that can be applied to the rapidly growing older population in Europe.

Publications

List of publications.
year	authors and title	journal	last update
2019	Zhengru Shen, Hugo van Krimpen, Marco Spruit A Lightweight API-Based Approach for Building Flexible Clinical NLP Systems published pages: 1-11, ISSN: 2040-2295, DOI: 10.1155/2019/3435609	Journal of Healthcare Engineering 2019	2020-04-22
2019	Luise Adam, Elisavet Moutzouri, Christine Baumgartner, Axel Lennart Loewe, Martin Feller, Khadija Mâ€™Rabet-Bensalah, Nathalie Schwab, Stefanie Hossmann, Claudio Schneider, Sabrina Jegerlehner, Carmen Floriani, Andreas Limacher, Katharina Tabea Jungo, Corlina Johanna Alida Huibers, Sven Streit, Matthias Schwenkglenks, Marco Spruit, Anette Van Dorland, Jacques DonzÃ©, Patricia M Kearney, Peter JÃ¼n Rationale and design of OPtimising thERapy to prevent Avoidable hospital admissions in Multimorbid older people (OPERAM): a cluster randomised controlled trial published pages: , ISSN: 2044-6055, DOI: 10.1136/bmjopen-2018-026769	BMJ Open 9:e026769	2020-04-22
2017	Maria Petropoulou, Dimitris Mavridis A comparison of 20 heterogeneity variance estimators in statistical synthesis of results from studies: a simulation study published pages: 4266-4280, ISSN: 0277-6715, DOI: 10.1002/sim.7431	Statistics in Medicine 36/27	2020-04-22
2018	Jean-Baptiste Beuscart, Wilma Knol, Shane Cullinan, Claudio Schneider, Olivia Dalleur, Benoit Boland, Stefanie Thevelin, Paul A. F. Jansen, Denis Oâ€™Mahony, Nicolas Rodondi, Anne Spinewine International core outcome set for clinical trials of medication review in multi-morbid older patients with polypharmacy published pages: , ISSN: 1741-7015, DOI: 10.1186/s12916-018-1007-9	BMC Medicine 16/1	2020-04-22
2017	Chaimani, Anna; Caldwell, Deborah M; Li, Tianjing; Higgins, Julian Pt; Salanti, Georgia Additional considerations are required when preparing a protocol for a systematic review with multiple interventions. published pages: 65-74, ISSN: 0895-4356, DOI: 10.7892/boris.94317	Journal of clinical epidemiology 83	2020-04-22
2018	O Riordan, David; Aubert, Carole Elodie; Walsh, Kieran A; Van Dorland, Anette; Rodondi, Nicolas; Du Puy, Robert S; Poortvliet, Rosalinde K E; Gussekloo, Jacobijn; Sinnott, Carol; Byrne, Stephen; Galvin, Rose; Jukema, J Wouter; Mooijaart, Simon P; Baumgartner, Christine; McCarthy, Vera; Walsh, Elaine K; Collet, Tinh-Hai; Dekkers, Olaf M; Blum, Manuel R; Kearney, Patricia M Prevalence of potentially inappropriate prescribing in a subpopulation of older European clinical trial participants: a cross-sectional study published pages: 1-10, ISSN: 2044-6055, DOI: 10.17863/CAM.24741	BMJ open 8	2020-04-22
2017	Beuscart, Jean Baptiste; Dalleur, Olivia; Boland, Benoit; Thevelin, Stefanie; Knol, Wilma; Cullinan, Shane; Schneider, Claudio; O\'Mahony, Denis; Rodondi, Nicolas; Spinewine, Anne Development of a core outcome set for medication review in older patients with multimorbidity and polypharmacy: a study protocol published pages: 1379-1389, ISSN: 1178-1998, DOI: 10.7892/boris.106338	Clinical Interventions in Aging Vo. 12	2020-04-22
2016	Zhengru Shen, Michiel Meulendijk, Marco Spruit A federated information architecture for multinational clinical trials: STRIPA revisited published pages: , ISSN: , DOI:	24th European Conference on Information Systems	2020-04-22
2019	Zhengru Shen, Marco Spruit A Systematic Review of Open Source Clinical Software on GitHub for Improving Software Reuse in Smart Healthcare published pages: 150, ISSN: 2076-3417, DOI: 10.3390/app9010150	Applied Sciences 9/1	2020-04-22
2018	Stefanie Thevelin, Anne Spinewine, Jean-Baptiste Beuscart, Benoit Boland, Sophie Marien, Fanny Vaillant, Ingeborg Wilting, Ariel Vondeling, Carmen Floriani, Claudio Schneider, Jacques DonzÃ©, Nicolas Rodondi, Shane Cullinan, Denis O\'Mahony, Olivia Dalleur Development of a standardized chart review method to identify drug-related hospital admissions in older people published pages: 2600-2614, ISSN: 0306-5251, DOI: 10.1111/bcp.13716	British Journal of Clinical Pharmacology 84/11	2020-04-22
2017	Jean-Baptiste Beuscart, Lisa G. Pont, Stefanie Thevelin, Benoit Boland, Olivia Dalleur, Anne W. S. Rutjes, Johanna I. Westbrook, Anne Spinewine A systematic review of the outcomes reported in trials of medication review in older patients: the need for a core outcome set published pages: 942-952, ISSN: 0306-5251, DOI: 10.1111/bcp.13197	British Journal of Clinical Pharmacology 83/5	2020-04-22

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