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FORECEE SIGNED

Female cancer prediction using cervical omics to individualise screening and prevention

Total Cost €

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EC-Contrib. €

0

Partnership

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Outcomes and
results

FORECEE project word cloud

Explore the words cloud of the FORECEE project. It provides you a very rough idea of what is the project "FORECEE" about.

effectiveness personalized individuals made breast disciplinary ethical economics benefit progression female team tandem participatory p4 environmental personalised causal output ovarian identification tract translation cervical opportunity decision human rapid agent ideal clinical cells examine smear individual tool direct hormone endometrial predictive abundant while halt llerian genome aligned dna behavioural experts progressed cancer omics quality public uuml communication utilise cancers papilloma risk lifetime prevention medicine technologies recording social accessibility hormonal m epigenome pipeline groups virus metagenome prediction invasive exposure forecee sensitive collected substantially enabled source preventive origin prevent window excellent strategy health screening recommendations stakeholder clinically progress oncology cell understand interaction trigger interventions infection readout translate

Project "FORECEE" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	http://www.forecee.eu
Total cost	7˙994˙746 €
EC max contribution	7˙994˙746 € (100%)
Programme	1. H2020-EU.3.1.2. (Preventing disease)
Code Call	H2020-PHC-2014-two-stage
Funding Scheme	RIA
Starting year	2015
Duration (year-month-day)	from 2015-09-01 to 2020-02-29

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITY COLLEGE LONDON UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	coordinator	3˙890˙699.00
2	KAROLINSKA INSTITUTET KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	participant	711˙182.00
3	Eurofins Genomics Europe Sequencing GmbH Eurofins Genomics Europe Sequencing GmbH Organization address address: JAKOB STADLER PLATZ 7 city: KONSTANZ postcode: 78467 website: www.gatc-biotech.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (KONSTANZ)	participant	558˙970.00
4	ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Organization address address: DR MOLEWATERPLEIN 40 city: ROTTERDAM postcode: 3015 GD website: www.erasmusmc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (ROTTERDAM)	participant	557˙866.00
5	ONCOTYROL-CENTER FOR PERSONALIZED CANCER MEDICINE GMBH ONCOTYROL-CENTER FOR PERSONALIZED CANCER MEDICINE GMBH Organization address address: KARL KAPFERER STRASSE 5/3 city: INNSBRUCK postcode: 6020 website: www.oncotyrol.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (INNSBRUCK)	participant	498˙440.00
6	UNIVERZITA KARLOVA UNIVERZITA KARLOVA Organization address address: OVOCNY TRH 560/5 city: PRAHA 1 postcode: 116 36 website: www.cuni.cz contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CZ (PRAHA 1)	participant	426˙520.00
7	LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN Organization address address: GESCHWISTER SCHOLL PLATZ 1 city: MUENCHEN postcode: 80539 website: www.uni-muenchen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	participant	299˙200.00
8	HELSE BERGEN HFHAUKELAND UNIVERSITY HOSPITAL HELSE BERGEN HFHAUKELAND UNIVERSITY HOSPITAL Organization address address: JONAS LIES VEI 65 city: BERGEN postcode: 5021 website: http://www.helse-bergen.no/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NO (BERGEN)	participant	269˙697.00
9	MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Organization address address: HOFGARTENSTRASSE 8 city: MUENCHEN postcode: 80539 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	participant	248˙987.00
10	LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER Organization address address: KEPPEL STREET city: LONDON postcode: WC1E 7HT website: http://www.lshtm.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	210˙077.00
11	ISTITUTO EUROPEO DI ONCOLOGIA SRL ISTITUTO EUROPEO DI ONCOLOGIA SRL Organization address address: Via Filodrammatici 10 city: MILANO postcode: 20121 website: www.ieo.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	participant	160˙500.00
12	EURAM LIMITED EURAM LIMITED Organization address address: LUCY TOWER STREET TOWER HOUSE city: LINCOLN postcode: LN1 1XW website: www.euram.ltd.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LINCOLN)	participant	83˙679.00
13	UNIVERSITY HOSPITALS SOUTHAMPTON NHS FOUNDATION TRUST UNIVERSITY HOSPITALS SOUTHAMPTON NHS FOUNDATION TRUST Organization address address: TREMONA ROAD city: SOUTHAMPTON postcode: SO16 6YD website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (SOUTHAMPTON)	participant	78˙926.00
14	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	participant	0.00

Map

Project objective

While prevention of most female specific cancers (ovarian, breast, endometrial) has not progressed substantially in recent years, significant progress has been made with cervical cancer due to accessibility of the cell of origin (cervical smear) and availability of a test for the causal agent (human papilloma virus); together these enable identification of high risk individuals and interventions to prevent infection or halt progression to invasive cancer. Our consortium has developed an exciting opportunity to utilise clinically abundant cervical cells in tandem with a multi-omics enabled (genome, epigenome, metagenome) analysis pipeline to understand an individual’s risk of developing a female specific cancer and to direct a personalised screening and prevention strategy. Cervical cells – currently collected within cervical cancer screening – provide an ideal window into other female specific cancers because they are (i) an excellent non-invasive source of high quality DNA, (ii) provide a readout for environmental exposure, (iii) are part of the Müllerian tract and (iv) are hormone sensitive, recording (via the epigenome) various hormonal conditions over a lifetime that trigger cancer development. The FORECEE project is aligned with the novel concept of “P4 Medicine” (predictive, preventive, personalized, and participatory): it aims to translate the risk prediction tool’s output into personalised recommendations for screening and prevention of female cancers. Our consortium comprises a multi-disciplinary team of experts in clinical oncology, risk-benefit communication, omics technologies, decision analysis, health economics and public health. We will examine the effectiveness of the proposed cervical cell omics analysis method and investigate the legal, social, ethical and behavioural issues related to implementation of the risk prediction tool, through direct interaction with stakeholder groups, to ensure its rapid translation into clinical practice across Europe.

Deliverables

List of deliverables.
Multimedia presentation available	Websites, patent fillings, videos etc.	2019-12-09 18:06:10
Leaflet and results from survey and public workshop results	Documents, reports	2019-12-09 18:06:10
Formal presentation to the ESGO patient advocacy group (ENGAGe)	Websites, patent fillings, videos etc.	2019-12-09 18:06:09
Project website	Websites, patent fillings, videos etc.	2019-12-09 18:06:09
Review on decision-analytic cost-effectiveness	Documents, reports	2019-12-09 18:06:09

Take a look to the deliverables list in detail: detailed list of FORECEE deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Maaike Alblas, Maartje Schermer, Yvonne Vergouwe, Ineke Bolt Autonomy Challenges in Epigenetic Risk-Stratified Cancer Screening: How Can Patient Decision Aids Support Informed Consent? published pages: 14, ISSN: 2075-4426, DOI: 10.3390/jpm9010014	Journal of Personalized Medicine 9/1	2019-12-09
2018	Odette Wegwarth, Martin Widschwendter, David Cibula, Karin SundstrÃ¶m, Rosalba Portuesi, Ines Lein, Felix G Rebitschek What do European women know about their female cancer risks and cancer screening? A cross-sectional online intervention survey in five European countries published pages: e023789, ISSN: 2044-6055, DOI: 10.1136/bmjopen-2018-023789	BMJ Open 8/12	2019-12-09
2018	Emmanuelle LÃ©vesque, Emily Kirby, Ineke Bolt, BarthaÂ Maria Knoppers, Inez deÂ Beaufort, Nora Pashayan, Martin Widschwendter Ethical, Legal, and Regulatory Issues for the Implementation of Omics-Based Risk Prediction of Womenâ€™s Cancer: Points to Consider published pages: 1-8, ISSN: 1662-4246, DOI: 10.1159/000492663	Public Health Genomics	2019-12-09
2018	Charles Dupras, Lingqiao Song, Katie M. Saulnier, Yann Joly Epigenetic Discrimination: Emerging Applications of Epigenetics Pointing to the Limitations of Policies Against Genetic Discrimination published pages: , ISSN: 1664-8021, DOI: 10.3389/fgene.2018.00202	Frontiers in Genetics 9	2019-12-09
2018	Martin Widschwendter, Allison Jones, Iona Evans, Daniel Reisel, Joakim Dillner, Karin SundstrÃ¶m, Ewout W. Steyerberg, Yvonne Vergouwe, Odette Wegwarth, Felix G. Rebitschek, Uwe Siebert, Gaby Sroczynski, Inez D. de Beaufort, Ineke Bolt, David Cibula, Michal Zikan, Line BjÃ¸rge, Nicoletta Colombo, Nadia Harbeck, Frank Dudbridge, Anne-Marie Tasse, Bartha M. Knoppers, Yann Joly, Andrew E. Teschendorff, Nora Pashayan Epigenome-based cancer risk prediction: rationale, opportunities and challenges published pages: 292-309, ISSN: 1759-4774, DOI: 10.1038/nrclinonc.2018.30	Nature Reviews Clinical Oncology 15/5	2019-12-09
2018	Maaike Alblas, Kimberley B. Velt, Nora Pashayan, Martin Widschwendter, Ewout W. Steyerberg, Yvonne Vergouwe Prediction models for endometrial cancer for the general population or symptomatic women: A systematic review published pages: 92-99, ISSN: 1040-8428, DOI: 10.1016/j.critrevonc.2018.03.023	Critical Reviews in Oncology/Hematology 126	2019-12-09
2016	Vit Weinberger, Marketa Bednarikova, David Cibula, Michal Zikan Serous tubal intraepithelial carcinoma (STIC) â€“ clinical impact and management published pages: 1311-1321, ISSN: 1473-7140, DOI: 10.1080/14737140.2016.1247699	Expert Review of Anticancer Therapy 16/12	2019-12-09
2016	Nora Pashayan, Daniel Reisel, Martin Widschwendter Integration of genetic and epigenetic markers for risk stratification: opportunities and challenges published pages: 93-95, ISSN: 1741-0541, DOI: 10.2217/pme.15.53	Personalized Medicine 13/2	2019-12-09

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