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NOMORFILM SIGNED

Novel marine biomolecules against biofilm. Application to medical devices.

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

NOMORFILM project word cloud

Explore the words cloud of the NOMORFILM project. It provides you a very rough idea of what is the project "NOMORFILM" about.

assured extracts molecules cultivation action cultures implant inflammation implants ecosystems iprs nomorfilm compounds antibiotic life toxicity nanoparticles agents secondary purpose deeply bacteria manufacture diminishing metabolites marketing structural industrially elucidation manufacturing incorporate source chemical removed biosynthesis bioactive release search health tests infection arise animal antimicrobial matrixes replaced agreements corresponding tissue anticipated mimicking co smes biofilm assure respect ways treatment episode mechanisms natural consumption isolated incorporated pathogens sustainable microalgae aquatic planktonic determined entailing interesting clinical antibiofilm diverse entities stage models stages infections medical antibacterial prosthetic bacterial screened species catheters

Project "NOMORFILM" data sheet

The following table provides information about the project.

Coordinator	FUNDACIO CENTRE DE RECERCA EN SALUT INTERNATIONAL DE BARCELONA There are not information about this coordinator. Please contact Fabio for more information, thanks.
Coordinator Country	Spain [ES]
Project website	http://www.nomorfilm.eu
Total cost	7˙651˙315 €
EC max contribution	7˙651˙315 € (100%)
Programme	1. H2020-EU.3.2. (SOCIETAL CHALLENGES - Food security, sustainable agriculture and forestry, marine, maritime and inland water research, and the bioeconomy)
Code Call	H2020-BG-2014-2
Funding Scheme	RIA
Starting year	2015
Duration (year-month-day)	from 2015-04-01 to 2019-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA Organization address address: C ROSSELLO 132 PLANTA 05 city: BARCELONA postcode: 8036 website: www.isglobal.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	coordinator	997˙085.00
2	FUNDACIO CENTRE DE RECERCA EN SALUT INTERNATIONAL DE BARCELONA FUNDACIO CENTRE DE RECERCA EN SALUT INTERNATIONAL DE BARCELONA Organization address address: CALLE VILLARROEL 170 city: Barcelona postcode: 8036 website: www.isglobal.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (Barcelona)	coordinator	0.00
3	PYROGENESIS SA PYROGENESIS SA Organization address address: ATHENS-LAVRION AVE, TECHNOLOGICAL PARK 1 city: LAVRION postcode: 19500 website: www.pyrogenesis-sa.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (LAVRION)	participant	729˙625.00
4	UNIVERSITA DEGLI STUDI DI FIRENZE UNIVERSITA DEGLI STUDI DI FIRENZE Organization address address: Piazza San Marco 4 city: Florence postcode: 50121 website: http://www.unifi.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (Florence)	participant	645˙975.00
5	KTEDOGEN SRL KTEDOGEN SRL Organization address address: VIA MONTE MORONE SNC city: MALNATE postcode: 21046 website: www.ktedogen.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MALNATE)	participant	633˙925.00
6	KOBENHAVNS UNIVERSITET KOBENHAVNS UNIVERSITET Organization address address: NORREGADE 10 city: KOBENHAVN postcode: 1165 website: www.ku.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KOBENHAVN)	participant	622˙285.00
7	UNIVERSIDAD DE OVIEDO UNIVERSIDAD DE OVIEDO Organization address address: CALLE SAN FRANCISCO 3 city: OVIEDO postcode: 33003 website: www.uniovi.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (OVIEDO)	participant	575˙288.00
8	UNIVERSIDADE DE COIMBRA UNIVERSIDADE DE COIMBRA Organization address address: PACO DAS ESCOLAS city: COIMBRA postcode: 3001 451 website: www.uc.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (COIMBRA)	participant	505˙821.00
9	KAROLINSKA INSTITUTET KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	participant	475˙000.00
10	FOTOSINTETICA & MICROBIOLOGICA SRL FOTOSINTETICA & MICROBIOLOGICA SRL Organization address address: VIA DI SANTO SPIRITO 14 city: FIRENZE FI postcode: 50125 website: www.femonline.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (FIRENZE FI)	participant	458˙075.00
11	SORBONNE UNIVERSITE SORBONNE UNIVERSITE Organization address address: 21 RUE DE L'ECOLE DE MEDECINE city: PARIS postcode: 75006 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	412˙375.00
12	THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN Organization address address: College Green city: DUBLIN postcode: 2 website: www.tcd.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (DUBLIN)	participant	358˙759.00
13	UNIVERSIDAD DE ALMERIA UNIVERSIDAD DE ALMERIA Organization address address: CARRETERA SACRAMENTO CANADA city: ALMERIA postcode: 4120 website: www.ual.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (ALMERIA)	participant	358˙031.00
14	CIIMAR - Centro Interdisciplinar de Investigação Marinha e Ambiental CIIMAR - Centro Interdisciplinar de Investigação Marinha e Ambiental Organization address address: Rua dos Bragas 289 city: Porto postcode: 4050-123 website: www.ciimar.up.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (Porto)	participant	337˙300.00
15	MBA INCORPORADO SL MBA INCORPORADO SL Organization address address: AVDA JARDIN BOTANICO 1345 EDIFICIO SILOS DEL INTRA city: GIJON postcode: 33203 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (GIJON)	participant	295˙000.00
16	NANOMEDPHARMA LTD NANOMEDPHARMA LTD Organization address address: HOPE BUSINESS GATEWAY EDEN BUILDING HOPE PARK city: LIVERPOOL postcode: L16 9JD website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LIVERPOOL)	participant	246˙770.00
17	UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6 UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6 Organization address address: Place Jussieu 4 city: PARIS postcode: 75252 website: www.upmc.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	0.00

Map

Project objective

Microalgae are a source of secondary metabolites useful as new bioactive compounds. Activity of these compounds against bacterial pathogens and biofilm formation has not been determined yet. Biofilm formation is especially important in infections and tissue inflammation related to implants and catheters. These problems finally cause a release of the implant, which must be removed and replaced by a new one, entailing an increase in antibiotic consumption, together with a health costs of about 50,000-90,000 € per infection episode. Taking both problems in account, the search of new antimicrobial agents that will be effective against the bacteria in their two ways of life, planktonic and biofilm stage, is a priority need in the clinical practice. For this reason, the overall objective of NOMORFILM project is to search for antibiofilm compounds isolated from microalgae that will be useful in the treatment of this kind of infections and could be incorporated in the manufacturing of medical prosthetic devices. For this purpose, 4,000 microalgae species will be deeply screened specifically for new antibacterial and antibiofilm molecules. Structural elucidation of bioactive compounds from these extracts will assure that only new chemical entities, therefore with anticipated new mechanisms of action, will arise to further project stages, those including toxicity tests and animal models. This project also addresses the biosynthesis of the targeted bioactive compounds in sustainable microalgae co-cultures, diminishing cultivation costs by mimicking natural aquatic ecosystems. Most industrially interesting antibiofilm molecules will be incorporated into nanoparticles in order to develop manufacturing methodologies able to incorporate these compounds into real prosthetic devices matrixes. Marketing of results are assured by the presence of diverse SMEs along the manufacture and distribution of prosthetic devices, and the corresponding consortium agreements with respect to IPRs

Deliverables

List of deliverables.
European network database for project strains	Documents, reports	2020-04-24 21:59:18
Parity document	Documents, reports	2020-04-24 22:00:33
Secondary scholars contest. M42	Websites, patent fillings, videos etc.	2020-04-24 22:01:07
At least one patent	Websites, patent fillings, videos etc.	2020-04-24 21:59:05
Presentation of the video clips. M51	Websites, patent fillings, videos etc.	2020-04-24 22:00:50
Secondary scholars contest. M30	Websites, patent fillings, videos etc.	2020-04-14 20:15:44
e-learning course	Websites, patent fillings, videos etc.	2020-04-14 20:15:44
Roadmap for EU marine biotechnology resources national policies. M36	Documents, reports	2020-04-14 20:15:44
Secondary scholars contest. M18	Websites, patent fillings, videos etc.	2020-04-14 20:15:44
Workshop on antibiofilm issues	Websites, patent fillings, videos etc.	2020-04-14 20:15:44
Random transposon library for selected pathogens	Documents, reports	2020-04-14 20:15:44
Presentation of NOMORFILM webpage and leaflet	Websites, patent fillings, videos etc.	2020-04-14 20:15:44
Secondary scholars contest. M9	Websites, patent fillings, videos etc.	2020-04-14 20:15:44
Roadmap for EU marine biotechnology resources national policies. M12	Documents, reports	2020-04-14 20:15:44
Presentation of the video clips. M6	Websites, patent fillings, videos etc.	2020-04-14 20:15:44

Take a look to the deliverables list in detail: detailed list of NOMORFILM deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	MarÃa JosÃ© Iglesias, Raquel Soengas, Clara B Martins, Maria JoÃ£o Correia, Joana D Ferreira, Lilia M.A. Santos, Fernando LÃ³pez Ortiz Chemotaxonomic profiling through NMR published pages: , ISSN: 0022-3646, DOI: 10.1111/jpy.12959	Journal of Phycology	2020-04-14
2020	Yuly LÃ³pez, Sara M. Soto The Usefulness of Microalgae Compounds for Preventing Biofilm Infections published pages: 9, ISSN: 2079-6382, DOI: 10.3390/antibiotics9010009	Antibiotics 9/1	2020-04-14
2018	Avinash Khandagale, Beatrice Lazzaretto, GÃ¶ran Carlsson, Mikael Sundin, Sulman Shafeeq, Ute RÃ¶mling, Bengt Fadeel JAGN1 is required for fungal killing in neutrophil extracellular traps: Implications for severe congenital neutropenia published pages: 1199-1213, ISSN: 0741-5400, DOI: 10.1002/jlb.4a0118-030rr	Journal of Leukocyte Biology 104/6	2020-04-14
2019	Virginio Cepas, Yuly LÃ³pez, Yaiza Gabasa, Clara B. Martins, Joana D. Ferreira, Maria J. Correia, LÃlia M.A. Santos, FlÃ¡vio Oliveira, Vitor Ramos, Mariana Reis, Raquel Castelo-Branco, JoÃ£o Morais, Vitor Vasconcelos, Ian Probert, Emilie Guilloud, Mohamed Mehiri, Sara M. Soto Inhibition of Bacterial and Fungal Biofilm Formation by 675 Extracts from Microalgae and Cyanobacteria published pages: 77, ISSN: 2079-6382, DOI: 10.3390/antibiotics8020077	Antibiotics 8/2	2020-04-14
2019	L.K. Jensen, N.L. Henriksen, S.A. Blirup, H.E. Jensen Guideline for Preclinical Studies of Bone Infections in Large Animals Based on a Systematic Review of 316 Non-Rodent Models published pages: 1894-1903, ISSN: 0021-9355, DOI: 10.2106/jbjs.18.01369	The Journal of Bone and Joint Surgery 101/21	2020-04-14
2019	Giampiero Pietrocola, Giulia Nobile, Mariangela J. Alfeo, Timothy J. Foster, Joan A. Geoghegan, Vincenzo De Filippis, Pietro Speziale Fibronectin-binding protein B (FnBPB) from Staphylococcus aureus protects against the antimicrobial activity of histones published pages: 3588-3602, ISSN: 0021-9258, DOI: 10.1074/jbc.ra118.005707	Journal of Biological Chemistry 294/10	2020-04-14
2019	Sulman Shafeeq, Srisuda Pannanusorn, Youssef Elsharabasy, Bernardo RamÃrez-Zavala, Joachim MorschhÃ¤user, Ute RÃ¶mling Impact of manganese on biofilm formation and cell morphology of Candida parapsilosis clinical isolates with different biofilm forming abilities published pages: , ISSN: 1567-1364, DOI: 10.1093/femsyr/foz057	FEMS Yeast Research 19/6	2020-04-14
2019	Ma JosÃ© Iglesias, Raquel Soengas, Ian Probert, Emilie Guilloud, Priscillia Gourvil, Mohamed Mehiri, Yuly LÃ³pez, Virginio Cepas, Ignacio GutiÃ©rrez-del-RÃo, SaÃºl Redondo-Blanco, Claudio J. Villar, Felipe LombÃ³, Sara Soto, Fernando LÃ³pez Ortiz NMR characterization and evaluation of antibacterial and antiobiofilm activity of organic extracts from stationary phase batch cultures of five marine microalgae (Dunaliella sp., D. salina, Chaetoceros calcitrans, C. gracilis and Tisochrysis lutea) published pages: 192-205, ISSN: 0031-9422, DOI: 10.1016/j.phytochem.2019.05.001	Phytochemistry 164	2020-04-14
2020	Freja Lea LÃ¼thje, Sophie Amalie Blirup-Plum, Nadia Sara MÃ¸ller, Peter M.H. Heegaard, Henrik Elvang Jensen, Klaus Kirketerp-MÃ¸ller, Hans Gottlieb, Kerstin Skovgaard, Louise Kruse Jensen The host response to bacterial bone infection involves a local upregulation of several acute phase proteins published pages: 151914, ISSN: 0171-2985, DOI: 10.1016/j.imbio.2020.151914	Immunobiology	2020-04-14
2020	Freja Lea LÃ¼thje, Louise Kruse Jensen, Henrik Elvang Jensen, Kerstin Skovgaard The inflammatory response to bone infection â€“ a review based on animal models and human patients published pages: , ISSN: 0903-4641, DOI: 10.1111/apm.13027	APMIS	2020-04-14
2019	Paolo Monciardini, Alice Bernasconi, Marianna Iorio, Cristina Brunati, Margherita Sosio, Laura Campochiaro, Paolo Landini, Sonia I. Maffioli, Stefano Donadio Antibacterial Aromatic Polyketides Incorporating the Unusual Amino Acid Enduracididine published pages: 35-44, ISSN: 0163-3864, DOI: 10.1021/acs.jnatprod.8b00354	Journal of Natural Products 82/1	2020-04-14
2017	Vitor Ramos, JoÃ£o Morais, Raquel Castelo-Branco, Ã‚ngela Pinheiro, Joana Martins, Ana Regueiras, Ana L. Pereira, Viviana R. Lopes, BÃ¡rbara FrazÃ£o, Dina Gomes, Cristiana Moreira, Maria Sofia Costa, SÃ©bastien BrÃ»le, Silvia Faustino, RosÃ¡rio Martins, Martin Saker, Joana Osswald, Pedro N. LeÃ£o, Vitor M. Vasconcelos Cyanobacterial diversity held in microbial biological resource centers as a biotechnological asset: the case study of the newly established LEGE culture collection published pages: , ISSN: 0921-8971, DOI: 10.1007/s10811-017-1369-y	Journal of Applied Phycology	2020-04-14
2018	Louise Kruse Jensen, Nicole Lind Henriksen, Thomas Bjarnsholt, Kasper NÃ¸rskov Kragh, Henrik Elvang Jensen Combined Staining Techniques for Demonstration of Staphylococcus aureus Biofilm in Routine Histopathology published pages: 27-36, ISSN: 2206-3552, DOI: 10.7150/jbji.22799	Journal of Bone and Joint Infection 3/1	2020-04-14
2017	Cristina Brunati, Thomas T Thomsen, Eleonora Gaspari, Sonia Maffioli, Margherita Sosio, Daniela Jabes, Anders LÃ¸bner-Olesen, Stefano Donadio Expanding the potential of NAI-107 for treating serious ESKAPE pathogens: synergistic combinations against Gram-negatives and bactericidal activity against non-dividing cells published pages: 414-424, ISSN: 0305-7453, DOI: 10.1093/jac/dkx395	Journal of Antimicrobial Chemotherapy 73/2	2020-04-14
2017	Louise K. Jensen, Anne S. B. Johansen, Henrik E. Jensen Porcine Models of Biofilm Infections with Focus on Pathomorphology published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2017.01961	Frontiers in Microbiology 8	2020-04-14
2019	P. Gkomoza, G.S. Lampropoulos, M. Vardavoulias, D.I. Pantelis, P.N. Karakizis, Ch. Sarafoglou Microstructural investigation of porous titanium coatings, produced by thermal spraying techniques, using plasma atomization and hydride-dehydride powders, for orthopedic implants published pages: 947-956, ISSN: 0257-8972, DOI: 10.1016/j.surfcoat.2018.10.072	Surface and Coatings Technology 357	2020-04-14
2019	P. Gkomoza, M. Vardavoulias, D.I. Pantelis, Ch. Sarafoglou Comparative study of structure and properties of thermal spray coatings using conventional and nanostructured hydroxyapatite powder, for applications in medical implants published pages: 748-758, ISSN: 0257-8972, DOI: 10.1016/j.surfcoat.2018.10.044	Surface and Coatings Technology 357	2020-04-14
2018	Yuly LÃ³pez, Virginio Cepas, Sara M. Soto Chapter 1: The Marine Ecosystem as a Source of Antibiotics published pages: 3-48, ISSN: , DOI: 10.1007/978-3-319-69075-9_1	Grand Challenges in Marine Biotechnology	2020-04-14
2019	Louise Kruse Jensen, Thomas Bjarnsholt, Kasper N. Kragh, Bent AalbÃ¦k, Nicole Lind Henriksen, Sophie Amalie Blirup, Karen Pankoke, Andreas Petersen, Henrik Elvang Jensen In Vivo Gentamicin Susceptibility Test for Prevention of Bacterial Biofilms in Bone Tissue and on Implants published pages: e01889-18, ISSN: 0066-4804, DOI: 10.1128/aac.01889-18	Antimicrobial Agents and Chemotherapy 63/2	2020-04-14
2015	Sara M. Soto The sea as a source of antibiotics published pages: , ISSN: 2327-5073, DOI:	Clinical Microbiology: Open Access Volume 4, Issue 4, 1000e126	2020-04-14
2015	Sara M. Soto GonzÃ¡lez and Felipe LombÃ³ Brugos BiopelÃculas y su relaciÃ³n con las infecciones protÃ©sicas published pages: 36 to 43, ISSN: 2444-1171, DOI:	Ortopedia & geriatrÃa profesional AÃ±o 1. NÃºmero 3. tercer trime	2020-04-14
2016	Pietrocola G, Nobile G, Gianotti V, Zapotoczna M, Foster TJ, Geoghegan JA, Speziale P. Molecular interactions of human plasminogen with FnBPB, a fibrinogen/fibronectin-binding protein from Staphylococcus aureus. published pages: , ISSN: 1083-351X, DOI:	J Biol Chem.	2020-04-14
2020	Ignacio GutiÃ©rrez-del-RÃo Nelly B. de Fraissinette Raquel Castelo-Branco Flavio Oliveira JoÃ£o Morais SaÃºl Redondo-Blanco Claudio J. Villar MarÃa JosÃ© Iglesias Raquel G. Soengas Virginio Cepas Yuly LÃ³pez Cubillos Giacomo Sampietro Liliana Rodolfi Felipe LombÃ³ Sara M. Soto GonzÃ¡lez Fernando LÃ³pez Ortiz Vitor M. Vasconcelos Mariana Reis Chlorosphaerolactylates A-D: the natural chlorinated lactylates isolated from the Portuguese cyanobacterium Sphaerospermopsis sp. LEGE 00249 published pages: , ISSN: 0000-0000, DOI: 10.26434/chemrxiv.11619873.v1	ChemRxiv 20.01.2020	2020-04-14
2017	Louise Kruse Jensen, Janne Koch, Kirstine Dich-Jorgensen, Bent Aalbaek, Andreas Petersen, Kurt Fuursted, Thomas Bjarnsholt, Kasper NÃ¸rskov Kragh, Mikkel TÃ¸tterup, Mats Bue, Pelle Hanberg, Kjeld SÃ¸balle, Peter M.H. Heegaard, Henrik Elvang Jensen Novel porcine model of implant-associated osteomyelitis: A comprehensive analysis of local, regional, and systemic response published pages: 2211-2221, ISSN: 0736-0266, DOI: 10.1002/jor.23505	Journal of Orthopaedic Research 35/10	2020-04-14

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "NOMORFILM" project.

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Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "NOMORFILM" are provided by the European Opendata Portal: CORDIS opendata.

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