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PROPAG-AGEING SIGNED

The continuum between healthy ageing and idiopathic Parkinson Disease within a propagation perspective of inflammation and damage: the search for new diagnostic, prognostic and therapeutic targets

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

PROPAG-AGEING project word cloud

Explore the words cloud of the PROPAG-AGEING project. It provides you a very rough idea of what is the project "PROPAG-AGEING" about.

somatic 4 risk str cohorts omic senescent diagnosis toxicants exposure added patients damage mandatory propagation therapies standard incident neurodegenerative understand neuronal ppmi indicate co dopaminergic gold validation showed followed first motor idiopathic biomaterials signatures profiles druggable neurons parkinson inflammaging 45 healthy posit ageing spreading cells enter brain prevalent disability protocol pathogenesis twin prion basic disease clinical informative mirrored innovative novo discovery molecular gt registry swedish therapy pd neuro twins deviating share ipsc brains identification trajectories signs offspring repository perturbations disorder lifestyle mechanisms protective discordant functional longitudinally collected vitro cellular data accumulation centenarians 1 de framework performing propag 65 phenomena never conceptualizations omics

Project "PROPAG-AGEING" data sheet

The following table provides information about the project.

Coordinator	AZIENDA UNITA' SANITARIA LOCALE DI BOLOGNA Organization address address: VIA CASTIGLIONE 29 city: BOLOGNA postcode: 40124 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Project website	http://www.propag-ageing.eu
Total cost	5˙993˙376 €
EC max contribution	5˙993˙376 € (100%)
Programme	1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
Code Call	H2020-PHC-2014-two-stage
Funding Scheme	RIA
Starting year	2015
Duration (year-month-day)	from 2015-09-01 to 2019-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	AZIENDA UNITA' SANITARIA LOCALE DI BOLOGNA AZIENDA UNITA' SANITARIA LOCALE DI BOLOGNA Organization address address: VIA CASTIGLIONE 29 city: BOLOGNA postcode: 40124 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (BOLOGNA)	coordinator	745˙437.00
2	UNIVERSITY COLLEGE LONDON UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	997˙057.00
3	KAROLINSKA INSTITUTET KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	participant	901˙232.00
4	CONSORZIO INTERUNIVERSITARIO RISONANZE MAGNETICHE DI METALLO PROTEINE CONSORZIO INTERUNIVERSITARIO RISONANZE MAGNETICHE DI METALLO PROTEINE Organization address address: PIAZZA SAN MARCO 4 city: FIRENZE postcode: 50121 website: www.cerm.unifi.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (FIRENZE)	participant	721˙261.00
5	UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS Organization address address: Robert-Koch-Strasse 40 city: GOETTINGEN postcode: 37075 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (GOETTINGEN)	participant	720˙968.00
6	SERVICIO ANDALUZ DE SALUD SERVICIO ANDALUZ DE SALUD Organization address address: AVENIDA DE LA CONSTITUCION 18 city: SEVILLA postcode: 41071 website: http://www.sas.junta-andalucia.es/principal/default.asp contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (SEVILLA)	participant	671˙167.00
7	PERSONAL GENOMICS SRL PERSONAL GENOMICS SRL Organization address address: VIA ROVEGGIA 43 city: VERONA postcode: 37136 website: www.personalgenomics.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (VERONA)	participant	635˙875.00
8	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	participant	308˙123.00
9	ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA Organization address address: VIA ZAMBONI 33 city: BOLOGNA postcode: 40126 website: www.unibo.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (BOLOGNA)	participant	292˙252.00

Map

Project objective

Ageing is the major risk factor for idiopathic PARKINSON'S DISEASE (PD), the first motor neurodegenerative disorder (in EU 1% in 65; about 4% in 80). The most recent conceptualizations of ageing and PD indicate that they share basic mechanisms, e.g. accumulation of senescent cells and propagation phenomena such as inflammaging mirrored in PD by neuro-inflammaging in brain that foster a prion-like spreading of neuronal damage. Thus, to fully understand PD pathogenesis and set up innovative neuro-protective therapies it is mandatory to posit PD within the framework of ageing process. The main goal of PROPAG-AGEING is to identify specific cellular and molecular perturbations deviating from healthy ageing trajectories towards PD. To this aim the project will exploit four large, very informative EXISTING COHORTS where biomaterials are available: i) de novo PD patients (before any therapy) followed longitudinally, including the largest repository of PD patients, i.e. PPMI; ii) centenarians and their offspring (CO) who never showed clinical signs of motor disability; iii) old twins of the Swedish Twin Registry (STR) followed longitudinally for >45 years, assessed for lifestyle and exposure to toxicants, and where incident and prevalent cases of PD discordant twins have been collected, including brains. The most informative sample from these cohorts will be studied in a DISCOVERY PHASE by an integrated set of omics to identify molecular signatures whose results will enter in a VALIDATION PHASE exploiting the four large cohorts, and performing functional in in vitro studies using dopaminergic neurons obtained by PD somatic cells from PD patients and centenarians via iPSC protocol. An added value is that omic data in centenarians and CO are available, and will represent the gold standard of healthy ageing. This approach will allow to identify new molecular profiles for early diagnosis and therapy (identification of druggable targets) of PD and signatures of healthy ageing.

Deliverables

List of deliverables.
Plan for Using and Disseminating Foreground	Documents, reports	2020-04-07 19:15:35
Project website	Websites, patent fillings, videos etc.	2020-04-07 19:15:34

Take a look to the deliverables list in detail: detailed list of PROPAG-AGEING deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2018	Rita Ostan, Daniela Monti, Daniela Mari, Beatrice Arosio, Davide Gentilini, Evelyn Ferri, Giuseppe Passarino, Francesco De Rango, Patrizia Dâ€™Aquila, Stefano Mariotti, Renato Pasquali, Flaminia Fanelli, Laura Bucci, Claudio Franceschi, Giovanni Vitale Heterogeneity of Thyroid Function and Impact of Peripheral Thyroxine Deiodination in Centenarians and Semi-Supercentenarians: Association With Functional Status and Mortality published pages: 802-810, ISSN: 1079-5006, DOI: 10.1093/gerona/gly194	The Journals of Gerontology: Series A 74/6	2020-04-07
2017	Diana L. Santos Ferreira, Dylan M. Williams, Antti J. Kangas, Pasi Soininen, Mika Ala-Korpela, George Davey Smith, Marjo-Riitta Jarvelin, Debbie A. Lawlor Association of pre-pregnancy body mass index with offspring metabolic profile: Analyses of 3 European prospective birth cohorts published pages: e1002376, ISSN: 1549-1676, DOI: 10.1371/journal.pmed.1002376	PLOS Medicine 14/8	2020-04-07
2018	Panteleimon G. Takis, Veronica Ghini, Leonardo Tenori, Paola Turano, Claudio Luchinat Uniqueness of the NMR approach to metabolomics published pages: 115300, ISSN: 0165-9936, DOI: 10.1016/j.trac.2018.10.036	TrAC Trends in Analytical Chemistry	2020-04-07
2019	Gianluca Storci, Sabrina De Carolis, Alessio Papi, Maria Giulia Bacalini, NoÃ©mie Gensous, Elena Marasco, Anna Tesei, Francesco Fabbri, Chiara Arienti, Michele Zanoni, Anna Sarnelli, Spartaco Santi, Fabiola Olivieri, Emanuela MensÃ , Silvia Latini, Manuela Ferracin, Stefano Salvioli, Paolo Garagnani, Claudio Franceschi, Massimiliano BonafÃ¨ Genomic stability, anti-inflammatory phenotype, and up-regulation of the RNAseH2 in cells from centenarians published pages: 1845-1858, ISSN: 1350-9047, DOI: 10.1038/s41418-018-0255-8	Cell Death & Differentiation 26/9	2020-04-07
2018	Vittorio Calabrese, Aurelia Santoro, Angela Trovato Salinaro, Sergio Modafferi, Maria Scuto, Ferdaous Albouchi, Daniela Monti, James Giordano, Mario Zappia, Claudio Franceschi, Edward J Calabrese Hormetic approaches to the treatment of Parkinson\'s disease: Perspectives and possibilities published pages: 1641-1662, ISSN: 0360-4012, DOI: 10.1002/jnr.24244	Journal of Neuroscience Research 96/10	2020-04-07
2019	Maria Conte, Morena Martucci, Marco Sandri, Claudio Franceschi, Stefano Salvioli The Dual Role of the Pervasive â€œFattishâ€ Tissue Remodeling With Age published pages: , ISSN: 1664-2392, DOI: 10.3389/fendo.2019.00114	Frontiers in Endocrinology 10	2020-04-07
2018	Maria Conte, Rita Ostan, Cristina Fabbri, Aurelia Santoro, Giulia Guidarelli, Giovanni Vitale, Daniela Mari, Federica Sevini, Miriam Capri, Marco Sandri, Daniela Monti, Claudio Franceschi, Stefano Salvioli Human Aging and Longevity Are Characterized by High Levels of Mitokines published pages: 600-607, ISSN: 1079-5006, DOI: 10.1093/gerona/gly153	The Journals of Gerontology: Series A 74/5	2020-04-07
2018	Maria Caracausi, Veronica Ghini, Chiara Locatelli, Martina Mericio, Allison Piovesan, Francesca Antonaros, Maria Chiara Pelleri, Lorenza Vitale, Rosa Anna Vacca, Federica Bedetti, Maria Chiara Mimmi, Claudio Luchinat, Paola Turano, Pierluigi Strippoli, Guido Cocchi Plasma and urinary metabolomic profiles of Down syndrome correlate with alteration of mitochondrial metabolism published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-20834-y	Scientific Reports 8/1	2020-04-07
2019	Alessia Vignoli, Leonardo Tenori, Betti Giusti, Panteleimon G. Takis, Serafina Valente, Nazario Carrabba, Daniela Balzi, Alessandro Barchielli, NiccolÃ² Marchionni, Gian Franco Gensini, Rossella Marcucci, Claudio Luchinat, Anna Maria Gori NMR-based metabolomics identifies patients at high risk of death within two years after acute myocardial infarction in the AMI-Florence II cohort published pages: , ISSN: 1741-7015, DOI: 10.1186/s12916-018-1240-2	BMC Medicine 17/1	2020-04-07
2019	Paolo Abondio, Marco Sazzini, Paolo Garagnani, Alessio Boattini, Daniela Monti, Claudio Franceschi, Donata Luiselli, Cristina Giuliani The Genetic Variability of APOE in Different Human Populations and Its Implications for Longevity published pages: 222, ISSN: 2073-4425, DOI: 10.3390/genes10030222	Genes 10/3	2020-04-07
2018	Cristina Giuliani, Paolo Garagnani, Claudio Franceschi Genetics of Human Longevity Within an Eco-Evolutionary Nature-Nurture Framework published pages: 745-772, ISSN: 0009-7330, DOI: 10.1161/circresaha.118.312562	Circulation Research 123/7	2020-04-07
2019	VeliÄkoviÄ‡, Petar; Fedus, William; Hamilton, William L; LiÃ², Pietro; Bengio, Yoshua; Hjelm, R Devon Deep Graph Infomax published pages: , ISSN: , DOI: 10.17863/CAM.40744	2	2020-04-07
2019	Alessia Vignoli, Veronica Ghini, Gaia Meoni, Cristina Licari, Panteleimon G. Takis, Leonardo Tenori, Paola Turano, Claudio Luchinat High-Throughput Metabolomics by 1D NMR published pages: 968-994, ISSN: 1433-7851, DOI: 10.1002/anie.201804736	Angewandte Chemie International Edition 58/4	2020-04-07
2019	Claudio Franceschi, Paolo Garagnani, NoÃ©mie Gensous, Maria Giulia Bacalini, Maria Conte, Stefano Salvioli Accelerated bioâ€cognitive aging in Down syndrome: State of the art and possible deceleration strategies published pages: e12903, ISSN: 1474-9718, DOI: 10.1111/acel.12903	Aging Cell 18/3	2020-04-07
2017	Claudio Franceschi, Paolo Garagnani, Giovanni Vitale, Miriam Capri, Stefano Salvioli Inflammaging and â€˜Garb-agingâ€™ published pages: 199-212, ISSN: 1043-2760, DOI: 10.1016/j.tem.2016.09.005	Trends in Endocrinology & Metabolism 28/3	2020-04-07
2017	Maria Giulia Bacalini, Joris Deelen, Chiara Pirazzini, Marco De Cecco, Cristina Giuliani, Catia Lanzarini, Francesco Ravaioli, Elena Marasco, Diana van Heemst, H. Eka D. Suchiman, Roderick Slieker, Enrico Giampieri, Rina Recchioni, Fiorella Mercheselli, Stefano Salvioli, Giovanni Vitale, Fabiola Olivieri, Annemieke M. W. Spijkerman, Martijn E. T. DollÃ©, John M. Sedivy, Gastone Castellani, Claudio Franceschi, Pieternella E. Slagboom, Paolo Garagnani Systemic Age-Associated DNA Hypermethylation of ELOVL2 Gene: In Vivo and In Vitro Evidences of a Cell Replication Process published pages: glw185, ISSN: 1079-5006, DOI: 10.1093/gerona/glw185	The Journals of Gerontology Series A: Biological Sciences and Medical Sciences	2020-04-07
2016	Panteleimon G. Takis, Leonardo Tenori, Enrico Ravera, Claudio Luchinat Gelified Biofluids for High-Resolution Magic Angle Spinning 1 H NMR Analysis: The Case of Urine published pages: 1054-1058, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.6b04318	Analytical Chemistry 89/2	2020-04-07
2017	Panteleimon G. Takis, Hartmut SchÃ¤fer, Manfred Spraul, Claudio Luchinat Deconvoluting interrelationships between concentrations and chemical shifts in urine provides a powerful analysis tool published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-01587-0	Nature Communications 8/1	2020-04-07
2018	Aurelia Santoro, Rita Ostan, Marco Candela, Elena Biagi, Patrizia Brigidi, Miriam Capri, Claudio Franceschi Gut microbiota changes in the extreme decades of human life: a focus on centenarians published pages: 129-148, ISSN: 1420-682X, DOI: 10.1007/s00018-017-2674-y	Cellular and Molecular Life Sciences 75/1	2020-04-07
2017	Claudio Franceschi, Stefano Salvioli, Paolo Garagnani, Magda de Eguileor, Daniela Monti, Miriam Capri Immunobiography and the Heterogeneity of Immune Responses in the Elderly: A Focus on Inflammaging and Trained Immunity published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2017.00982	Frontiers in Immunology 8	2020-04-07
2018	Cristina Giuliani, Marco Sazzini, Chiara Pirazzini, Maria Giulia Bacalini, Elena Marasco, Guido Alberto Gnecchi Ruscone, Fang Fang, Stefania Sarno, Davide Gentilini, Anna Maria Di Blasio, Paolina Crocco, Giuseppe Passarino, Daniela Mari, Daniela Monti, Benedetta Nacmias, Sandro Sorbi, Carlo Salvarani, Mariagrazia Catanoso, Davide Pettener, Donata Luiselli, Svetlana Ukraintseva, Anatoliy Yashin, Claudio Franceschi, Paolo Garagnani Impact of demography and population dynamics on the genetic architecture of human longevity published pages: , ISSN: 1945-4589, DOI: 10.18632/aging.101515	Aging	2020-04-07
2017	T. Guastafierro, M. G. Bacalini, A. Marcoccia, D. Gentilini, S. Pisoni, A. M. Di Blasio, A. Corsi, C. Franceschi, D. Raimondo, A. SpanÃ², P. Garagnani, F. Bondanini Genome-wide DNA methylation analysis in blood cells from patients with Werner syndrome published pages: , ISSN: 1868-7075, DOI: 10.1186/s13148-017-0389-4	Clinical Epigenetics 9/1	2020-04-07
2017	Beatrice Arosio, Rita Ostan, Daniela Mari, Sarah Damanti, Francesco Ronchetti, Sara Arcudi, Maria Scurti, Claudio Franceschi, Daniela Monti Cognitive status in the oldest old and centenarians: a condition crucial for quality of life methodologically difficult to assess published pages: 185-194, ISSN: 0047-6374, DOI: 10.1016/j.mad.2017.02.010	Mechanisms of Ageing and Development 165	2020-04-07
2017	Danielle Fernandes Durso, Maria Giulia Bacalini, Claudia Sala, Chiara Pirazzini, Elena Marasco, Massimiliano BonafÃ©, Ãtalo Faria do Valle, Davide Gentilini, Gastone Castellani, Ana Maria Caetano Faria, Claudio Franceschi, Paolo Garagnani, Christine Nardini \"Acceleration of leukocytes’ epigenetic age as an early tumor and sex-specific marker of breast and colorectal cancer\" published pages: , ISSN: 1949-2553, DOI: 10.18632/oncotarget.15573	Oncotarget 8/14	2020-04-07
2017	NoÃ©mie Gensous, Maria Giulia Bacalini, Chiara Pirazzini, Elena Marasco, Cristina Giuliani, Francesco Ravaioli, Giacomo Mengozzi, Claudia Bertarelli, Maria Giustina Palmas, Claudio Franceschi, Paolo Garagnani The epigenetic landscape of age-related diseases: the geroscience perspective published pages: 549-559, ISSN: 1389-5729, DOI: 10.1007/s10522-017-9695-7	Biogerontology 18/4	2020-04-07
2018	Yunzhang Wang, Nancy L. Pedersen, Sara HÃ¤gg Implementing a method for studying longitudinal DNA methylation variability in association with age published pages: 866-874, ISSN: 1559-2294, DOI: 10.1080/15592294.2018.1521222	Epigenetics 13/8	2020-04-07
2018	Dylan M. Williams, Ida K. Karlsson, Nancy L. Pedersen, Sara HÃ¤gg Circulating insulin-like growth factors and Alzheimer disease published pages: e291-e297, ISSN: 0028-3878, DOI: 10.1212/WNL.0000000000004854	Neurology 90/4	2020-04-07
2018	Francesco Ravaioli, Maria Bacalini, Claudio Franceschi, Paolo Garagnani Age-Related Epigenetic Derangement upon Reprogramming and Differentiation of Cells from the Elderly published pages: 39, ISSN: 2073-4425, DOI: 10.3390/genes9010039	Genes 9/1	2020-04-07
2018	Hagg, Sara; Pedersen, Nancy; Jylhava, Juulia; Williams, Dylan A frailty index for UK Biobank participants published pages: , ISSN: 1758-535X, DOI: 10.1101/233692	The journals of gerontology. Series A, Biological sciences and medical sciences. 2	2020-04-07
2015	Steve Horvath, Chiara Pirazzini, Maria Giulia Bacalini, Davide Gentilini, Anna Maria Di Blasio, Massimo Delledonne, Daniela Mari, Beatrice Arosio, Daniela Monti, Giuseppe Passarino, Francesco De Rango, Patrizia D\'Aquila, Cristina Giuliani, Elena Marasco, Sebastiano Collino, Patrick Descombes, Paolo Garagnani, Claudio Franceschi Decreased epigenetic age of PBMCs from Italian semi-supercentenarians and their offspring published pages: 1159-1170, ISSN: 1945-4589, DOI: 10.18632/aging.100861	Aging 7/12	2020-04-07
2015	Deborah Finkel, Marie Ernsth-Bravell, Nancy L. Pedersen Temporal Dynamics of Motor Functioning and Cognitive Aging published pages: 109-116, ISSN: 1079-5006, DOI: 10.1093/gerona/glv110	The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 71/1	2020-04-07
2018	Claudio Franceschi, Paolo Garagnani, Cristina Morsiani, Maria Conte, Aurelia Santoro, Andrea Grignolio, Daniela Monti, Miriam Capri, Stefano Salvioli The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates published pages: , ISSN: 2296-858X, DOI: 10.3389/fmed.2018.00061	Frontiers in Medicine 5	2020-04-07
2016	Johanna Sieurin, Petter Gustavsson, Caroline Elise Weibull, Adina Leiah Feldman, Giselle Maria Petzinger, Margaret Gatz, Nancy Lee Pedersen, Karin Wirdefeldt Personality traits and the risk for Parkinson disease: a prospective study published pages: 169-175, ISSN: 0393-2990, DOI: 10.1007/s10654-015-0062-1	European Journal of Epidemiology 31/2	2020-04-07
2016	Fei Yang, Anna L.V. Johansson, Nancy L. Pedersen, Fang Fang, Margaret Gatz, Karin Wirdefeldt Socioeconomic status in relation to ParkinsonÊ¼s disease risk and mortality published pages: e4337, ISSN: 0025-7974, DOI: 10.1097/MD.0000000000004337	Medicine 95/30	2020-04-07
2017	Carol E. Franz, Deborah Finkel, Matthew S. Panizzon, Kelly Spoon, Kaare Christensen, Margaret Gatz, William S. Kremen, Robert Krueger, Jenae Neiderhiser, Chandra Reynolds, Nancy L. Pedersen Facets of Subjective Health From Early Adulthood to Old Age published pages: 149-171, ISSN: 0898-2643, DOI: 10.1177/0898264315625488	Journal of Aging and Health 29/1	2020-04-07
2015	Jesper O.E. Carlson, Margaret Gatz, Nancy L. Pedersen, Caroline Graff, Inger Nennesmo, Anna-Karin LindstrÃ¶m, Lotte Gerritsen Antemortem Prediction of Braak Stage published pages: 1061-1070, ISSN: 0022-3069, DOI: 10.1097/NEN.0000000000000251	Journal of Neuropathology & Experimental Neurology 74/11	2020-04-07
2016	Kari Berglund, Chandra A. Reynolds, Alexander Ploner, Lotte Gerritsen, Iiris Hovatta, Nancy L. Pedersen, Sara HÃ¤gg Longitudinal decline of leukocyte telomere length in old age and the association with sex and genetic risk published pages: 1398-1415, ISSN: 1945-4589, DOI: 10.18632/aging.100995	Aging 8/7	2020-04-07

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