NOVA SIGNED
Non-coding RNA in Vascular Ageing
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0NOVA project word cloud
Explore the words cloud of the NOVA project. It provides you a very rough idea of what is the project "NOVA" about.
Project "NOVA" data sheet
The following table provides information about the project.
| Coordinator |
JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN
Organization address contact info |
| Coordinator Country | Germany [DE] |
| Project website | http://www.boonlab.eu |
| Total cost | 1˙499˙693 € |
| EC max contribution | 1˙499˙693 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2014-STG |
| Funding Scheme | ERC-STG |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-04-01 to 2021-03-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN | DE (FRANKFURT AM MAIN) | coordinator | 1˙499˙693.00 |
Map
Project objective
Life expectancy in the European Union is rising and the prevalence of age-induced cardiovascular disease increases concomitantly. Endothelial dysfunction is a hallmark of aging in the vasculature and is the underlying cause of many cardiovascular disorders, like hypertension, acute myocardial infarction and stroke. This proposal aims to better understand the molecular mechanisms behind aging that lead to endothelial dysfunction. Non-coding RNAs are emerging as novel key regulators of cellular functions and we hypothesize that non-coding RNAs contribute to vascular aging. Preliminary experiments show that several long non-coding RNAs (lncRNAs) are regulated during aging of the cardiovascular system, including the lncRNA H19. We propose to extensively characterize the role of H19 in endothelial aging and to identify other lncRNAs that are involved in vascular aging. We will use state-of-the-art in vitro and in vivo models to assess endothelial aging and function upon gain-of-function and loss-of-function of lncRNAs. Understanding the role that H19 and other lncRNAs play in aging endothelium will highlight novel potential therapeutic targets to attenuate age-induced endothelial dysfunction. The focus on aging will also yield insight in molecular mechanisms that may have been overlooked when studying endothelial function in young cells or organisms.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2018 |
Philipp Neumann, Nicolas Jaé, Andrea Knau, Simone F. Glaser, Youssef Fouani, Oliver Rossbach, Marcus Krüger, David John, Albrecht Bindereif, Phillip Grote, Reinier A. Boon, Stefanie Dimmeler The lncRNA GATA6-AS epigenetically regulates endothelial gene expression via interaction with LOXL2 published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-02431-1 |
Nature Communications 9/1 | 2020-01-30 |
| 2016 |
Reinier A. Boon, Patrick Hofmann, Katharina M. Michalik, Noelia Lozano-Vidal, Denise Berghäuser, Ariane Fischer, Andrea Knau, Nicolas Jaé, Christoph Schürmann, Stefanie Dimmeler Long Noncoding RNA Meg3 Controls Endothelial Cell Aging and Function published pages: 2589-2591, ISSN: 0735-1097, DOI: 10.1016/j.jacc.2016.09.949 |
Journal of the American College of Cardiology 68/23 | 2019-12-09 |
| 2016 |
Reinier A. Boon, Nicolas Jaé, Lesca Holdt, Stefanie Dimmeler Long Noncoding RNAs published pages: 1214-1226, ISSN: 0735-1097, DOI: 10.1016/j.jacc.2015.12.051 |
Journal of the American College of Cardiology 67/10 | 2019-12-09 |
| 2018 |
Kosta Theodorou, Reinier A. Boon Endothelial Cell Metabolism in Atherosclerosis published pages: , ISSN: 2296-634X, DOI: 10.3389/fcell.2018.00082 |
Frontiers in Cell and Developmental Biology 6 | 2019-12-09 |
| 2018 |
Patrick Hofmann, Janina Sommer, Kosta Theodorou, Luisa Kirchhof, Ariane Fischer, Yuhuang Li, Ljubica Perisic, Ulf Hedin, Lars Maegdefessel, Stefanie Dimmeler, Reinier A Boon Long non-coding RNA H19 regulates endothelial cell aging via inhibition of STAT3 signalling published pages: 230-242, ISSN: 0008-6363, DOI: 10.1093/cvr/cvy206 |
Cardiovascular Research 115/1 | 2019-12-09 |
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "NOVA" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "NOVA" are provided by the European Opendata Portal: CORDIS opendata.