Explore the words cloud of the MODELAGE project. It provides you a very rough idea of what is the project "MODELAGE" about.
The following table provides information about the project.
Coordinator |
UNIVERSIDAD DE ZARAGOZA
Organization address contact info |
Coordinator Country | Spain [ES] |
Project website | http://www.estherpueyo.com/erc-stg-grant/ |
Total cost | 1˙498˙636 € |
EC max contribution | 1˙498˙636 € (100%) |
Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
Code Call | ERC-2014-STG |
Funding Scheme | ERC-STG |
Starting year | 2015 |
Duration (year-month-day) | from 2015-10-01 to 2020-09-30 |
Take a look of project's partnership.
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1 | UNIVERSIDAD DE ZARAGOZA | ES (ZARAGOZA) | coordinator | 1˙498˙636.00 |
Europe is facing a striking change in its demographics with an increasingly larger proportion of citizens aged 65 years and over. Aging is characterized by a progressive decline in the physiological functions of the body, with very notable effects on the heart. These effects are associated with a higher prevalence of arrhythmias, which, on top of deteriorating quality of life, increase the risk of other cardiovascular diseases like stroke, heart failure and neurological sequelae. Investigations targeting cardiac aging have often focused on assessing the effects of a specific contributing factor, at a single evaluation scale (molecular, cell, tissue, organ) and in many cases using animal species not relevant to humans in terms of aging mechanisms. MODELAGE proposes a multi-scale, multi-factorial research that is expected to make an important step in the characterization of human heart aging at both the population and individual levels. MODELAGE will work on an integrative methodological framework in which in silico modeling will be combined with in vitro cell and tissue analysis and in vivo electrocardiographic evaluation to investigate how cardiac aging manifests at a range of scales, from cell to body surface, and how electrical, structural and autonomic alterations contribute to such manifestations in humans. Indices describing spatio-temporal dynamics of cardiac electrophysiology will be evaluated in a population of young to senescent individuals using a novel feedback control approach. Inter-individual age-related variations in those indices will be assessed and correlated with markers of biological age (as opposed to chronological age). By investigating the mechanisms underlying inter-individual differences in cardiac dynamics, MODELAGE will set links to arrhythmia susceptibility and will propose novel non-invasive markers to identify high-risk senescent individuals for which preventive anti-arrhythmic treatment should be considered.
year | authors and title | journal | last update |
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2017 |
Carlos Sánchez, Alfonso Bueno-Orovio, Esther Pueyo, Blanca RodrÃguez Atrial Fibrillation Dynamics and Ionic Block Effects in Six Heterogeneous Human 3D Virtual Atria with Distinct Repolarization Dynamics published pages: , ISSN: 2296-4185, DOI: 10.3389/fbioe.2017.00029 |
Frontiers in Bioengineering and Biotechnology 5 | 2019-05-29 |
2018 |
Estel Ramos Noncoding RNA-mediated metabolic regulation in health and disease published pages: , ISSN: , DOI: |
Genomic parasites and noncoding RNA-mediated metabolic regulation in health and disease | 2019-05-29 |
2018 |
Jesús Fernández-Bes, David A. Sampedro, Esther Pueyo A Bayesian Filtering methodology to identify key drivers of ventricular repolarization variability published pages: , ISSN: , DOI: |
Virtual Physiological Human 2018 | 2019-05-29 |
2017 |
Julia RamÃrez, Michele Orini, Ana Mincholé, Violeta Monasterio, Iwona Cygankiewicz, Antonio Bayés de Luna, Juan Pablo MartÃnez, Pablo Laguna, Esther Pueyo Sudden cardiac death and pump failure death prediction in chronic heart failure by combining ECG and clinical markers in an integrated risk model published pages: e0186152, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0186152 |
PLOS ONE 12/10 | 2019-05-29 |
2017 |
Esther Pueyo, Michele Orini, José Félix RodrÃguez, Peter Taggart In-silico investigation of ANS-Heart interactions: Implications for cardiac arrhythmias and therapeutic apporaches published pages: , ISSN: , DOI: |
In silico drug safety and efficacy Symposium | 2019-05-29 |
2018 |
Laura Ordovás, Aida Oliván-Viguera, Estel Ramos, Laura GarcÃa-MendÃvil, Esther Pueyo Chunk isolation of adult pig cardiomyocytes for electrophysiological, histological and molecular studies published pages: , ISSN: 1664-042X, DOI: |
Frontiers in Physiology To be submitted | 2019-05-29 |
2018 |
Michael P. Gilbey, Esther Pueyo, Peter Taggart The kinetic behavior of sympathetic nerve activity as an arrhythmogenic mechanism published pages: , ISSN: 2041-1723, DOI: |
Nature Communications To be submitted | 2019-05-29 |
2018 |
David A. Sampedro, Jesús Fernandez-Bes, Esther Pueyo Characterization of individual cardiac cell properties and dynamic states by nonlinear filtering methods published pages: , ISSN: 1007-5704, DOI: |
Communications in Nonlinear Science and Numerical Simulations To be submitted | 2019-05-29 |
2018 |
David Adolfo Sampedro-Puente, Jesus Fernandez-Bes, László Virág, András Varró, Esther Pueyo Data-driven Identification of Stochastic Model Parameters and State Variables: Application to theStudy of Cardiac Beat-to-beat Variability published pages: , ISSN: 0018-9294, DOI: |
IEEE Transactions on Biomedical and Health Informatics Under review | 2019-05-29 |
2016 |
José Vicente Ruiz, David G. Strauss (Supervisor), Esther Pueyo (Supervisor) Novel electrocardiographic biomarkers for proarrhythmic assessment of drugs published pages: , ISSN: , DOI: |
Doctoral Thesis | 2019-05-29 |
2018 |
Juan Bolea, Raquel Bailón, Esther Pueyo On the Standardization of Approximate Entropy: Multidimensional Approximate Entropy Index Evaluated on Short-Term HRV Time Series published pages: 1-15, ISSN: 1076-2787, DOI: 10.1155/2018/4953273 |
Complexity 2018 | 2019-05-29 |
2017 |
Julia RamÃrez, Esther Pueyo (Supervisor), Pablo Laguna (Supervisor) Prediction of Cardiac Death Risk by Analysis of Ventricular Repolarization Restitution from the Electrocardiogram Signal published pages: , ISSN: 2254-7606, DOI: |
Doctoral Thesis | 2019-05-29 |
2017 |
Jesús Carro, José F. RodrÃguez-Matas, Violeta Monasterio, Esther Pueyo Limitations in electrophysiological model development and validation caused by differences between simulations and experimental protocols published pages: 53-64, ISSN: 0079-6107, DOI: 10.1016/j.pbiomolbio.2016.11.006 |
Progress in Biophysics and Molecular Biology 129 | 2019-05-29 |
2017 |
Jesús Carro, José F RodrÃguez-Matas, Esther Pueyo A Methodology to Improve Human Ventricular Models for the Investigation of Cardiac Arrhythmias published pages: 403a, ISSN: 0006-3495, DOI: 10.1016/j.bpj.2016.11.2183 |
Biophysical Journal 112/3 | 2019-05-29 |
2016 |
E. Pueyo, C. E. Dangerfield, O. J. Britton, L. Virág, K. Kistamás, N. Szentandrássy, N. Jost, A. Varró, P. P. Nánási, K. Burrage, B. RodrÃguez Experimentally-Based Computational Investigation into Beat-To-Beat Variability in Ventricular Repolarization and Its Response to Ionic Current Inhibition published pages: e0151461, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0151461 |
PLOS ONE 11/3 | 2019-05-29 |
2018 |
Estel Ramos-Marquès, Laura GarcÃa-Mendivil, Juan Carlos Oliveros, Rafael Torres-Pérez, Aida Olivan-Viguera, Laura Ordovás, Esther Pueyo Analysis of the role of microRNA in age-related heart electrophysiological remodeling published pages: , ISSN: , DOI: |
Cell Symposia Aging and Metabolism 2018 Abstract submission | 2019-05-29 |
2016 |
Juan Bolea, Esther Pueyo, Michele Orini, Raquel Bailón Influence of Heart Rate in Non-linear HRV Indices as a Sampling Rate Effect Evaluated on Supine and Standing published pages: 00501(12pp), ISSN: 1664-042X, DOI: 10.3389/fphys.2016.00501 |
Frontiers in Physiology 7 | 2019-05-29 |
2018 |
Esther Pueyo Characterization of abnormal cardiac dynamics in aged and failing hearts: insights from experimental and computational research published pages: , ISSN: , DOI: |
QBIO IV 2018 | 2019-05-29 |
2018 |
Jesús Carro, José F. RodrÃguez (Supervisor), Esther Pueyo (Supervisor) New methodologies for the development and validation of cardiac electrophysiological models published pages: , ISSN: , DOI: |
Doctoral Thesis | 2019-05-29 |
2020 |
Laura GarcÃa, Laura Ordovás (Supervisor), Esther Pueyo (Supervisor) In silico and in vitro modeling of cardiac aging for cardiovascular disease prevention published pages: , ISSN: , DOI: |
Doctoral Thesis | 2019-05-29 |
2016 |
Esther Pueyo, Michele Orini, José F. RodrÃguez, Peter Taggart Interactive effect of beta-adrenergic stimulation and mechanical stretch on low-frequency oscillations of ventricular action potential duration in humans published pages: 93-105, ISSN: 0022-2828, DOI: 10.1016/j.yjmcc.2016.05.003 |
Journal of Molecular and Cellular Cardiology 97 | 2019-05-29 |
2018 |
Pablo V. Gracia, Esther Pueyo (Supervisor) Characterization of the contribution of electrical, structural and autonomic factors to atrial fibrillation published pages: , ISSN: , DOI: |
Doctoral Thesis | 2019-05-29 |
2016 |
Pablo Laguna, Juan Pablo Martinez Cortes, Esther Pueyo Techniques for Ventricular Repolarization Instability Assessment From the ECG published pages: 392-415, ISSN: 0018-9219, DOI: 10.1109/JPROC.2015.2500501 |
Proceedings of the IEEE 104/2 | 2019-05-29 |
2018 |
Eleonora Grandi, Stefano Morotti, Esther Pueyo, Blanca RodrÃguez Getting to the Heart of Safety Pharmacology published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2018.00678 |
Frontiers in Physiology | 2019-05-29 |
2018 |
David Adolfo Sampedro-Puente, Jesús Fernández-Bes, Bradley Porter, Stefan Van Duijvenboden, Peter Taggart, Esther Pueyo Mechanisms underlying interactions between low-frequency oscillations and beat-to-beat repolarization variability during sympathetic provocation. Implications for arrhythmogenesis published pages: , ISSN: 1664-042X, DOI: |
Frontiers in Physiology To be submitted | 2019-05-29 |
2017 |
Julia Ramirez, Michele Orini, J. Derek Tucker, Esther Pueyo, Pablo Laguna Variability of Ventricular Repolarization Dispersion Quantified by Time-Warping the Morphology of the T-Waves published pages: 1619-1630, ISSN: 0018-9294, DOI: 10.1109/TBME.2016.2614899 |
IEEE Transactions on Biomedical Engineering 64/7 | 2019-05-29 |
2018 |
Jesús Carro, Esther Pueyo, José F. RodrÃguez Matas A response surface optimization approach to adjust ionic current conductances of cardiac electrophysiological models. Application to the study of potassium level changes published pages: e0204411, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0204411 |
PLOS ONE 13/10 | 2019-05-29 |
2018 |
Laura GarcÃa-MendÃvil, Estel Ramos-Marquès, Juan Carlos Oliveros, Rafael Torres-Pérez, Jesús Fernández-Bes, Aida Olivan-Viguera, Esther Pueyo, Laura Ordovás Transcriptional analysis of human cardiac aging by chronological and biological age published pages: , ISSN: , DOI: |
Cell Symposia Aging and Metabolism 2018 Abstract submission | 2019-05-29 |
2019 |
David Sampedro, Esther Pueyo (Supervisor) Theoretical analysis of the effects of the Autonomic Nervous System on human cardiac electrophysiology and its relation to arrhythmic risk published pages: , ISSN: , DOI: |
Doctoral Thesis | 2019-05-29 |
2018 |
David A. Sampedro, Jesús Fernandez-Bes, Bradley Porter, Stefan Van Duijvenboden, Peter Taggart, Esther Pueyo Mechanisms underlying interactions between low-frequency oscillations and beat-to-beat repolarization variability in the human ventricles undersympathetic provocation published pages: , ISSN: , DOI: |
42nd European Working Group on Cardiac Cellular Electrophysiology Annual Meeting | 2019-05-29 |
2016 |
Jose Vicente, Lars Johannesen, Meisam Hosseini, Jay W. Mason, Philip T. Sager, Esther Pueyo, David G. Strauss Electrocardiographic Biomarkers for Detection of Drug-Induced Late Sodium Current Block published pages: e0163619, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0163619 |
PLOS ONE 11/12 | 2019-05-29 |
2018 |
David A. Sampedro, Jesús Fernandez-Bes, Bradley Porter,
Stefan Van Duijvenboden, Peter Taggart, Esther Pueyo Mechanisms underlying interactions between low-frequency oscillations and beat-to-beat repolarization variability under sympathetic provocation published pages: , ISSN: , DOI: |
Virtual Physiological Human 2018 | 2019-05-29 |
2017 |
Julia RamÃrez, Michele Orini, Ana Mincholé, Violeta Monasterio, Iwona Cygankiewicz, Antonio Bayés de Luna, Juan Pablo MartÃnez, Esther Pueyo, Pablo Laguna Tâ€Wave Morphology Restitution Predicts Sudden Cardiac Death in Patients With Chronic Heart Failure published pages: e005310, ISSN: 2047-9980, DOI: 10.1161/JAHA.116.005310 |
Journal of the American Heart Association 6/5 | 2019-05-29 |
2017 |
michele orini, Esther Pueyo, Pablo Laguna, Raquel Bailon A Time-Varying Non-Parametric Methodology for Assessing Changes in QT Variability Unrelated to Heart Rate Variability published pages: 1-1, ISSN: 0018-9294, DOI: 10.1109/TBME.2017.2758925 |
IEEE Transactions on Biomedical Engineering | 2019-05-29 |
2018 |
Juan Bolea, Raquel Bailón (Supervisor), Esther Pueyo (Supervisor) Time-frequency analysis of heart rate variability for characterization of autonomic impairments published pages: , ISSN: , DOI: |
Doctoral Thesis | 2019-05-29 |
2018 |
Aida Olivan-Viguera, Angel Luis Garcia-Otin, Javier Lozano-Gerona, Edgar Abarca-Lachen, Ana J. Garcia-Malinis, Kirk L. Hamilton, Yolanda Gilaberte, Esther Pueyo, Ralf Köhler Pharmacological activation of TRPV4 produces immediate cell damage and induction of apoptosis in human melanoma cells and HaCaT keratinocytes published pages: e0190307, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0190307 |
PLOS ONE 13/1 | 2019-05-29 |
2018 |
Estel Ramos, Laura Ordovás, Laura GarcÃa-MendÃvil, Rafael Torres-Pérez, Juan Carlos Oliveros, Aida Oliván-Viguera, Esther Pueyo Deciphering the role of key microRNAs involved in regulating electro-mechanical left ventricular function during the course of aging published pages: , ISSN: 0009-7322, DOI: |
Circulation: Genomics and Precision Medicine To be submitted | 2019-05-29 |
2017 |
Jesús Carro, José F. RodrÃguez, Esther Pueyo Multiscale Methods for Definition of Ionic Variables in Electrophysiological Models published pages: 123, ISSN: , DOI: |
EMBEC\'17 & NBC\'17 | 2019-05-29 |
2018 |
Julia RamÃrez, Michele Orini, Ana Mincholé, Violeta Monasterio, Iwona Cygankiewicz, Antonio Bayés de Luna, Juan Pablo MartÃnez, Esther Pueyo, Pablo Laguna Correction: Tâ€Wave Morphology Restitution Predicts Sudden Cardiac Death in Patients With Chronic Heart Failure published pages: , ISSN: 2047-9980, DOI: |
Journal of the American Heart Association | 2019-04-25 |
2018 |
Jesús Carro, José F. RodrÃguez-Matas, Violeta Monasterio, Esther Pueyo Corrigendum to “Limitations in electrophysiological model development and validation caused by differences between simulations and experimental protocols†[Prog. Biophys. Mol. Biol. 129 (2017) 53–64] published pages: , ISSN: 0079-6107, DOI: 10.1016/j.pbiomolbio.2018.11.001 |
Progress in Biophysics and Molecular Biology | 2019-04-25 |
2018 |
Juan Bolea, Esther Pueyo, Michele Orini, Raquel Bailón Corrigendum: Influence of Heart Rate in Non-linear HRV Indices as a Sampling Rate Effect Evaluated on Supine and Standing published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2018.00620 |
Frontiers in Physiology 9 | 2019-04-25 |
2018 |
Esther Pueyo La ingenierÃa como herramienta para combatir las enfermedades cardiovasculares published pages: , ISSN: , DOI: |
Congreso de IngenierÃa Hospitalaria | 2019-04-25 |
2018 |
Esther Pueyo Understanding heart function through combined clinical, experimental and computational research published pages: , ISSN: , DOI: |
Virtual Physiological Human Summer School 2018 | 2019-04-25 |
2018 |
Esther Pueyo My ERC experience published pages: , ISSN: , DOI: |
Virtual Physiological Human 2018 | 2019-04-25 |
2018 |
Jose Vicente, Lars Johannesen, Meisam Hosseini, Jay W. Mason, Philip T. Sager, Esther Pueyo, David G. Strauss Correction: Electrocardiographic Biomarkers for Detection of Drug-Induced Late Sodium Current Block published pages: e0197952, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0197952 |
PLOS ONE 13/5 | 2019-04-25 |
2018 |
E. Pueyo, C. E. Dangerfield, O. J. Britton, L. Virág, K. Kistamás, N. Szentandrássy, N. Jost, A. Varró, P. P. Nánási, K. Burrage, B. RodrÃguez Correction: Experimentally-Based Computational Investigation into Beat-To-Beat Variability in Ventricular Repolarization and Its Response to Ionic Current Inhibition published pages: e0197871, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0197871 |
PLOS ONE 13/5 | 2019-04-25 |
2018 |
David A. Sampedro-Puente, Laura GarcÃa-MendÃvil, Estel Ramos-Marquès, Aida Olivan-Viguera, Jesús Fernandez-Bes, Laura Ordovas, Eesther Pueyo Cardiac dynamics and arrhythmic risk in aged and failing hearts: insights from experimental and computational research published pages: , ISSN: , DOI: |
Virtual Physiological Human 2018 | 2019-04-25 |
2018 |
Esther Pueyo, Michele Orini, José F. RodrÃguez, Peter Taggart Corrigendum to “Interactive effect of beta-adrenergic stimulation and mechanical stretch on low-frequency oscillations of ventricular action potential duration in humans†[J. Mol. Cell. Cardiol. 97 (2016) 93–105] published pages: 305, ISSN: 0022-2828, DOI: 10.1016/j.yjmcc.2018.05.006 |
Journal of Molecular and Cellular Cardiology 121 | 2019-04-25 |
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