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MODELAGE SIGNED

Is your heart aging well? A systems biology approach to characterize cardiac aging from the cell to the body surface

Total Cost €

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EC-Contrib. €

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 Outcomes and results

 MODELAGE project word cloud

Explore the words cloud of the MODELAGE project. It provides you a very rough idea of what is the project "MODELAGE" about.

inter    investigations    individual    spatio    methodological    vitro    individuals    differences    species    age    integrative    dynamics    susceptibility    aging    chronological    body    links    larger    proposes    electrocardiographic    variations    aged    temporal    electrophysiology    cardiac    modeling    citizens    notable    arrhythmias    manifestations    indices    treatment    arrhythmic    diseases    striking    proportion    combined    framework    correlated    electrical    population    structural    life    scales    modelage    sequelae    tissue    alterations    heart    underlying    molecular    factorial    stroke    prevalence    assessing    organ    physiological    human    cell    biological    neurological    manifests    deteriorating    autonomic    young    europe    progressive    humans    cardiovascular    invasive    single    opposed    describing    mechanisms    65    decline    risk    arrhythmia    senescent    quality    characterization    evaluation    preventive    levels    vivo    feedback    surface    demographics    markers    functions    animal    silico    anti   

Project "MODELAGE" data sheet

The following table provides information about the project.

Coordinator		 UNIVERSIDAD DE ZARAGOZA 

Organization address
address: CALLE PEDRO CERBUNA 12
city: ZARAGOZA
postcode: 50009
website: www.unizar.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Spain [ES]
 Project website http://www.estherpueyo.com/erc-stg-grant/
 Total cost 1˙498˙636 €
 EC max contribution 1˙498˙636 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2020-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD DE ZARAGOZA ES (ZARAGOZA) coordinator 1˙498˙636.00

Map

 Project objective

Europe is facing a striking change in its demographics with an increasingly larger proportion of citizens aged 65 years and over. Aging is characterized by a progressive decline in the physiological functions of the body, with very notable effects on the heart. These effects are associated with a higher prevalence of arrhythmias, which, on top of deteriorating quality of life, increase the risk of other cardiovascular diseases like stroke, heart failure and neurological sequelae. Investigations targeting cardiac aging have often focused on assessing the effects of a specific contributing factor, at a single evaluation scale (molecular, cell, tissue, organ) and in many cases using animal species not relevant to humans in terms of aging mechanisms. MODELAGE proposes a multi-scale, multi-factorial research that is expected to make an important step in the characterization of human heart aging at both the population and individual levels. MODELAGE will work on an integrative methodological framework in which in silico modeling will be combined with in vitro cell and tissue analysis and in vivo electrocardiographic evaluation to investigate how cardiac aging manifests at a range of scales, from cell to body surface, and how electrical, structural and autonomic alterations contribute to such manifestations in humans. Indices describing spatio-temporal dynamics of cardiac electrophysiology will be evaluated in a population of young to senescent individuals using a novel feedback control approach. Inter-individual age-related variations in those indices will be assessed and correlated with markers of biological age (as opposed to chronological age). By investigating the mechanisms underlying inter-individual differences in cardiac dynamics, MODELAGE will set links to arrhythmia susceptibility and will propose novel non-invasive markers to identify high-risk senescent individuals for which preventive anti-arrhythmic treatment should be considered.

 Publications

year authors and title journal last update
List of publications.
2017 Carlos Sánchez, Alfonso Bueno-Orovio, Esther Pueyo, Blanca Rodríguez
Atrial Fibrillation Dynamics and Ionic Block Effects in Six Heterogeneous Human 3D Virtual Atria with Distinct Repolarization Dynamics
published pages: , ISSN: 2296-4185, DOI: 10.3389/fbioe.2017.00029 		Frontiers in Bioengineering and Biotechnology 5 2019-05-29
2018 Estel Ramos
Noncoding RNA-mediated metabolic regulation in health and disease
published pages: , ISSN: , DOI: 		Genomic parasites and noncoding RNA-mediated metabolic regulation in health and disease 2019-05-29
2018 Jesús Fernández-Bes, David A. Sampedro, Esther Pueyo
A Bayesian Filtering methodology to identify key drivers of ventricular repolarization variability
published pages: , ISSN: , DOI: 		Virtual Physiological Human 2018 2019-05-29
2017 Julia Ramírez, Michele Orini, Ana Mincholé, Violeta Monasterio, Iwona Cygankiewicz, Antonio Bayés de Luna, Juan Pablo Martínez, Pablo Laguna, Esther Pueyo
Sudden cardiac death and pump failure death prediction in chronic heart failure by combining ECG and clinical markers in an integrated risk model
published pages: e0186152, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0186152 		PLOS ONE 12/10 2019-05-29
2017 Esther Pueyo, Michele Orini, José Félix Rodríguez, Peter Taggart
In-silico investigation of ANS-Heart interactions: Implications for cardiac arrhythmias and therapeutic apporaches
published pages: , ISSN: , DOI: 		In silico drug safety and efficacy Symposium 2019-05-29
2018 Laura Ordovás, Aida Oliván-Viguera, Estel Ramos, Laura García-Mendívil, Esther Pueyo
Chunk isolation of adult pig cardiomyocytes for electrophysiological, histological and molecular studies
published pages: , ISSN: 1664-042X, DOI: 		Frontiers in Physiology To be submitted 2019-05-29
2018 Michael P. Gilbey, Esther Pueyo, Peter Taggart
The kinetic behavior of sympathetic nerve activity as an arrhythmogenic mechanism
published pages: , ISSN: 2041-1723, DOI: 		Nature Communications To be submitted 2019-05-29
2018 David A. Sampedro, Jesús Fernandez-Bes, Esther Pueyo
Characterization of individual cardiac cell properties and dynamic states by nonlinear filtering methods
published pages: , ISSN: 1007-5704, DOI: 		Communications in Nonlinear Science and Numerical Simulations To be submitted 2019-05-29
2018 David Adolfo Sampedro-Puente, Jesus Fernandez-Bes, László Virág, András Varró, Esther Pueyo
Data-driven Identification of Stochastic Model Parameters and State Variables: Application to theStudy of Cardiac Beat-to-beat Variability
published pages: , ISSN: 0018-9294, DOI: 		IEEE Transactions on Biomedical and Health Informatics Under review 2019-05-29
2016 José Vicente Ruiz, David G. Strauss (Supervisor), Esther Pueyo (Supervisor)
Novel electrocardiographic biomarkers for proarrhythmic assessment of drugs
published pages: , ISSN: , DOI: 		Doctoral Thesis 2019-05-29
2018 Juan Bolea, Raquel Bailón, Esther Pueyo
On the Standardization of Approximate Entropy: Multidimensional Approximate Entropy Index Evaluated on Short-Term HRV Time Series
published pages: 1-15, ISSN: 1076-2787, DOI: 10.1155/2018/4953273 		Complexity 2018 2019-05-29
2017 Julia Ramírez, Esther Pueyo (Supervisor), Pablo Laguna (Supervisor)
Prediction of Cardiac Death Risk by Analysis of Ventricular Repolarization Restitution from the Electrocardiogram Signal
published pages: , ISSN: 2254-7606, DOI: 		Doctoral Thesis 2019-05-29
2017 Jesús Carro, José F. Rodríguez-Matas, Violeta Monasterio, Esther Pueyo
Limitations in electrophysiological model development and validation caused by differences between simulations and experimental protocols
published pages: 53-64, ISSN: 0079-6107, DOI: 10.1016/j.pbiomolbio.2016.11.006 		Progress in Biophysics and Molecular Biology 129 2019-05-29
2017 Jesús Carro, José F Rodríguez-Matas, Esther Pueyo
A Methodology to Improve Human Ventricular Models for the Investigation of Cardiac Arrhythmias
published pages: 403a, ISSN: 0006-3495, DOI: 10.1016/j.bpj.2016.11.2183 		Biophysical Journal 112/3 2019-05-29
2016 E. Pueyo, C. E. Dangerfield, O. J. Britton, L. Virág, K. Kistamás, N. Szentandrássy, N. Jost, A. Varró, P. P. Nánási, K. Burrage, B. Rodríguez
Experimentally-Based Computational Investigation into Beat-To-Beat Variability in Ventricular Repolarization and Its Response to Ionic Current Inhibition
published pages: e0151461, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0151461 		PLOS ONE 11/3 2019-05-29
2018 Estel Ramos-Marquès, Laura García-Mendivil, Juan Carlos Oliveros, Rafael Torres-Pérez, Aida Olivan-Viguera, Laura Ordovás, Esther Pueyo
Analysis of the role of microRNA in age-related heart electrophysiological remodeling
published pages: , ISSN: , DOI: 		Cell Symposia Aging and Metabolism 2018 Abstract submission 2019-05-29
2016 Juan Bolea, Esther Pueyo, Michele Orini, Raquel Bailón
Influence of Heart Rate in Non-linear HRV Indices as a Sampling Rate Effect Evaluated on Supine and Standing
published pages: 00501(12pp), ISSN: 1664-042X, DOI: 10.3389/fphys.2016.00501 		Frontiers in Physiology 7 2019-05-29
2018 Esther Pueyo
Characterization of abnormal cardiac dynamics in aged and failing hearts: insights from experimental and computational research
published pages: , ISSN: , DOI: 		QBIO IV 2018 2019-05-29
2018 Jesús Carro, José F. Rodríguez (Supervisor), Esther Pueyo (Supervisor)
New methodologies for the development and validation of cardiac electrophysiological models
published pages: , ISSN: , DOI: 		Doctoral Thesis 2019-05-29
2020 Laura García, Laura Ordovás (Supervisor), Esther Pueyo (Supervisor)
In silico and in vitro modeling of cardiac aging for cardiovascular disease prevention
published pages: , ISSN: , DOI: 		Doctoral Thesis 2019-05-29
2016 Esther Pueyo, Michele Orini, José F. Rodríguez, Peter Taggart
Interactive effect of beta-adrenergic stimulation and mechanical stretch on low-frequency oscillations of ventricular action potential duration in humans
published pages: 93-105, ISSN: 0022-2828, DOI: 10.1016/j.yjmcc.2016.05.003 		Journal of Molecular and Cellular Cardiology 97 2019-05-29
2018 Pablo V. Gracia, Esther Pueyo (Supervisor)
Characterization of the contribution of electrical, structural and autonomic factors to atrial fibrillation
published pages: , ISSN: , DOI: 		Doctoral Thesis 2019-05-29
2016 Pablo Laguna, Juan Pablo Martinez Cortes, Esther Pueyo
Techniques for Ventricular Repolarization Instability Assessment From the ECG
published pages: 392-415, ISSN: 0018-9219, DOI: 10.1109/JPROC.2015.2500501 		Proceedings of the IEEE 104/2 2019-05-29
2018 Eleonora Grandi, Stefano Morotti, Esther Pueyo, Blanca Rodríguez
Getting to the Heart of Safety Pharmacology
published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2018.00678 		Frontiers in Physiology 2019-05-29
2018 David Adolfo Sampedro-Puente, Jesús Fernández-Bes, Bradley Porter, Stefan Van Duijvenboden, Peter Taggart, Esther Pueyo
Mechanisms underlying interactions between low-frequency oscillations and beat-to-beat repolarization variability during sympathetic provocation. Implications for arrhythmogenesis
published pages: , ISSN: 1664-042X, DOI: 		Frontiers in Physiology To be submitted 2019-05-29
2017 Julia Ramirez, Michele Orini, J. Derek Tucker, Esther Pueyo, Pablo Laguna
Variability of Ventricular Repolarization Dispersion Quantified by Time-Warping the Morphology of the T-Waves
published pages: 1619-1630, ISSN: 0018-9294, DOI: 10.1109/TBME.2016.2614899 		IEEE Transactions on Biomedical Engineering 64/7 2019-05-29
2018 Jesús Carro, Esther Pueyo, José F. Rodríguez Matas
A response surface optimization approach to adjust ionic current conductances of cardiac electrophysiological models. Application to the study of potassium level changes
published pages: e0204411, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0204411 		PLOS ONE 13/10 2019-05-29
2018 Laura García-Mendívil, Estel Ramos-Marquès, Juan Carlos Oliveros, Rafael Torres-Pérez, Jesús Fernández-Bes, Aida Olivan-Viguera, Esther Pueyo, Laura Ordovás
Transcriptional analysis of human cardiac aging by chronological and biological age
published pages: , ISSN: , DOI: 		Cell Symposia Aging and Metabolism 2018 Abstract submission 2019-05-29
2019 David Sampedro, Esther Pueyo (Supervisor)
Theoretical analysis of the effects of the Autonomic Nervous System on human cardiac electrophysiology and its relation to arrhythmic risk
published pages: , ISSN: , DOI: 		Doctoral Thesis 2019-05-29
2018 David A. Sampedro, Jesús Fernandez-Bes, Bradley Porter, Stefan Van Duijvenboden, Peter Taggart, Esther Pueyo
Mechanisms underlying interactions between low-frequency oscillations and beat-to-beat repolarization variability in the human ventricles undersympathetic provocation
published pages: , ISSN: , DOI: 		42nd European Working Group on Cardiac Cellular Electrophysiology Annual Meeting 2019-05-29
2016 Jose Vicente, Lars Johannesen, Meisam Hosseini, Jay W. Mason, Philip T. Sager, Esther Pueyo, David G. Strauss
Electrocardiographic Biomarkers for Detection of Drug-Induced Late Sodium Current Block
published pages: e0163619, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0163619 		PLOS ONE 11/12 2019-05-29
2018 David A. Sampedro, Jesús Fernandez-Bes, Bradley Porter, Stefan Van Duijvenboden, Peter Taggart, Esther Pueyo
Mechanisms underlying interactions between low-frequency oscillations and beat-to-beat repolarization variability under sympathetic provocation
published pages: , ISSN: , DOI: 		Virtual Physiological Human 2018 2019-05-29
2017 Julia Ramírez, Michele Orini, Ana Mincholé, Violeta Monasterio, Iwona Cygankiewicz, Antonio Bayés de Luna, Juan Pablo Martínez, Esther Pueyo, Pablo Laguna
T‐Wave Morphology Restitution Predicts Sudden Cardiac Death in Patients With Chronic Heart Failure
published pages: e005310, ISSN: 2047-9980, DOI: 10.1161/JAHA.116.005310 		Journal of the American Heart Association 6/5 2019-05-29
2017 michele orini, Esther Pueyo, Pablo Laguna, Raquel Bailon
A Time-Varying Non-Parametric Methodology for Assessing Changes in QT Variability Unrelated to Heart Rate Variability
published pages: 1-1, ISSN: 0018-9294, DOI: 10.1109/TBME.2017.2758925 		IEEE Transactions on Biomedical Engineering 2019-05-29
2018 Juan Bolea, Raquel Bailón (Supervisor), Esther Pueyo (Supervisor)
Time-frequency analysis of heart rate variability for characterization of autonomic impairments
published pages: , ISSN: , DOI: 		Doctoral Thesis 2019-05-29
2018 Aida Olivan-Viguera, Angel Luis Garcia-Otin, Javier Lozano-Gerona, Edgar Abarca-Lachen, Ana J. Garcia-Malinis, Kirk L. Hamilton, Yolanda Gilaberte, Esther Pueyo, Ralf Köhler
Pharmacological activation of TRPV4 produces immediate cell damage and induction of apoptosis in human melanoma cells and HaCaT keratinocytes
published pages: e0190307, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0190307 		PLOS ONE 13/1 2019-05-29
2018 Estel Ramos, Laura Ordovás, Laura García-Mendívil, Rafael Torres-Pérez, Juan Carlos Oliveros, Aida Oliván-Viguera, Esther Pueyo
Deciphering the role of key microRNAs involved in regulating electro-mechanical left ventricular function during the course of aging
published pages: , ISSN: 0009-7322, DOI: 		Circulation: Genomics and Precision Medicine To be submitted 2019-05-29
2017 Jesús Carro, José F. Rodríguez, Esther Pueyo
Multiscale Methods for Definition of Ionic Variables in Electrophysiological Models
published pages: 123, ISSN: , DOI: 		EMBEC\'17 & NBC\'17 2019-05-29
2018 Julia Ramírez, Michele Orini, Ana Mincholé, Violeta Monasterio, Iwona Cygankiewicz, Antonio Bayés de Luna, Juan Pablo Martínez, Esther Pueyo, Pablo Laguna
Correction: T‐Wave Morphology Restitution Predicts Sudden Cardiac Death in Patients With Chronic Heart Failure
published pages: , ISSN: 2047-9980, DOI: 		Journal of the American Heart Association 2019-04-25
2018 Jesús Carro, José F. Rodríguez-Matas, Violeta Monasterio, Esther Pueyo
Corrigendum to “Limitations in electrophysiological model development and validation caused by differences between simulations and experimental protocols” [Prog. Biophys. Mol. Biol. 129 (2017) 53–64]
published pages: , ISSN: 0079-6107, DOI: 10.1016/j.pbiomolbio.2018.11.001 		Progress in Biophysics and Molecular Biology 2019-04-25
2018 Juan Bolea, Esther Pueyo, Michele Orini, Raquel Bailón
Corrigendum: Influence of Heart Rate in Non-linear HRV Indices as a Sampling Rate Effect Evaluated on Supine and Standing
published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2018.00620 		Frontiers in Physiology 9 2019-04-25
2018 Esther Pueyo
La ingeniería como herramienta para combatir las enfermedades cardiovasculares
published pages: , ISSN: , DOI: 		Congreso de Ingeniería Hospitalaria 2019-04-25
2018 Esther Pueyo
Understanding heart function through combined clinical, experimental and computational research
published pages: , ISSN: , DOI: 		Virtual Physiological Human Summer School 2018 2019-04-25
2018 Esther Pueyo
My ERC experience
published pages: , ISSN: , DOI: 		Virtual Physiological Human 2018 2019-04-25
2018 Jose Vicente, Lars Johannesen, Meisam Hosseini, Jay W. Mason, Philip T. Sager, Esther Pueyo, David G. Strauss
Correction: Electrocardiographic Biomarkers for Detection of Drug-Induced Late Sodium Current Block
published pages: e0197952, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0197952 		PLOS ONE 13/5 2019-04-25
2018 E. Pueyo, C. E. Dangerfield, O. J. Britton, L. Virág, K. Kistamás, N. Szentandrássy, N. Jost, A. Varró, P. P. Nánási, K. Burrage, B. Rodríguez
Correction: Experimentally-Based Computational Investigation into Beat-To-Beat Variability in Ventricular Repolarization and Its Response to Ionic Current Inhibition
published pages: e0197871, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0197871 		PLOS ONE 13/5 2019-04-25
2018 David A. Sampedro-Puente, Laura García-Mendívil, Estel Ramos-Marquès, Aida Olivan-Viguera, Jesús Fernandez-Bes, Laura Ordovas, Eesther Pueyo
Cardiac dynamics and arrhythmic risk in aged and failing hearts: insights from experimental and computational research
published pages: , ISSN: , DOI: 		Virtual Physiological Human 2018 2019-04-25
2018 Esther Pueyo, Michele Orini, José F. Rodríguez, Peter Taggart
Corrigendum to “Interactive effect of beta-adrenergic stimulation and mechanical stretch on low-frequency oscillations of ventricular action potential duration in humans” [J. Mol. Cell. Cardiol. 97 (2016) 93–105]
published pages: 305, ISSN: 0022-2828, DOI: 10.1016/j.yjmcc.2018.05.006 		Journal of Molecular and Cellular Cardiology 121 2019-04-25

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