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MODELAGE SIGNED

Is your heart aging well? A systems biology approach to characterize cardiac aging from the cell to the body surface

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

MODELAGE project word cloud

Explore the words cloud of the MODELAGE project. It provides you a very rough idea of what is the project "MODELAGE" about.

chronological 65 progressive organ manifests surface vivo population scales factorial cardiac anti quality deteriorating investigations tissue proportion susceptibility cardiovascular striking risk characterization europe electrocardiographic aged sequelae levels physiological vitro opposed methodological links young alterations combined dynamics arrhythmias describing modeling arrhythmic human inter aging demographics heart prevalence individuals life functions differences treatment animal electrical spatio invasive individual notable larger framework structural body manifestations markers feedback preventive molecular modelage assessing autonomic humans citizens arrhythmia mechanisms cell correlated silico decline biological single species temporal integrative proposes neurological stroke indices variations senescent electrophysiology underlying diseases evaluation age

Project "MODELAGE" data sheet

The following table provides information about the project.

Coordinator	UNIVERSIDAD DE ZARAGOZA Organization address address: CALLE PEDRO CERBUNA 12 city: ZARAGOZA postcode: 50009 website: www.unizar.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Project website	http://www.estherpueyo.com/erc-stg-grant/
Total cost	1˙498˙636 €
EC max contribution	1˙498˙636 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2014-STG
Funding Scheme	ERC-STG
Starting year	2015
Duration (year-month-day)	from 2015-10-01 to 2020-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSIDAD DE ZARAGOZA UNIVERSIDAD DE ZARAGOZA Organization address address: CALLE PEDRO CERBUNA 12 city: ZARAGOZA postcode: 50009 website: www.unizar.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (ZARAGOZA)	coordinator	1˙498˙636.00

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Project objective

Europe is facing a striking change in its demographics with an increasingly larger proportion of citizens aged 65 years and over. Aging is characterized by a progressive decline in the physiological functions of the body, with very notable effects on the heart. These effects are associated with a higher prevalence of arrhythmias, which, on top of deteriorating quality of life, increase the risk of other cardiovascular diseases like stroke, heart failure and neurological sequelae. Investigations targeting cardiac aging have often focused on assessing the effects of a specific contributing factor, at a single evaluation scale (molecular, cell, tissue, organ) and in many cases using animal species not relevant to humans in terms of aging mechanisms. MODELAGE proposes a multi-scale, multi-factorial research that is expected to make an important step in the characterization of human heart aging at both the population and individual levels. MODELAGE will work on an integrative methodological framework in which in silico modeling will be combined with in vitro cell and tissue analysis and in vivo electrocardiographic evaluation to investigate how cardiac aging manifests at a range of scales, from cell to body surface, and how electrical, structural and autonomic alterations contribute to such manifestations in humans. Indices describing spatio-temporal dynamics of cardiac electrophysiology will be evaluated in a population of young to senescent individuals using a novel feedback control approach. Inter-individual age-related variations in those indices will be assessed and correlated with markers of biological age (as opposed to chronological age). By investigating the mechanisms underlying inter-individual differences in cardiac dynamics, MODELAGE will set links to arrhythmia susceptibility and will propose novel non-invasive markers to identify high-risk senescent individuals for which preventive anti-arrhythmic treatment should be considered.

Publications

List of publications.
year	authors and title	journal	last update
2017	Carlos SÃ¡nchez, Alfonso Bueno-Orovio, Esther Pueyo, Blanca RodrÃguez Atrial Fibrillation Dynamics and Ionic Block Effects in Six Heterogeneous Human 3D Virtual Atria with Distinct Repolarization Dynamics published pages: , ISSN: 2296-4185, DOI: 10.3389/fbioe.2017.00029	Frontiers in Bioengineering and Biotechnology 5	2019-05-29
2018	Estel Ramos Noncoding RNA-mediated metabolic regulation in health and disease published pages: , ISSN: , DOI:	Genomic parasites and noncoding RNA-mediated metabolic regulation in health and disease	2019-05-29
2018	JesÃºs FernÃ¡ndez-Bes, David A. Sampedro, Esther Pueyo A Bayesian Filtering methodology to identify key drivers of ventricular repolarization variability published pages: , ISSN: , DOI:	Virtual Physiological Human 2018	2019-05-29
2017	Julia RamÃrez, Michele Orini, Ana MincholÃ©, Violeta Monasterio, Iwona Cygankiewicz, Antonio BayÃ©s de Luna, Juan Pablo MartÃnez, Pablo Laguna, Esther Pueyo Sudden cardiac death and pump failure death prediction in chronic heart failure by combining ECG and clinical markers in an integrated risk model published pages: e0186152, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0186152	PLOS ONE 12/10	2019-05-29
2017	Esther Pueyo, Michele Orini, JosÃ© FÃ©lix RodrÃguez, Peter Taggart In-silico investigation of ANS-Heart interactions: Implications for cardiac arrhythmias and therapeutic apporaches published pages: , ISSN: , DOI:	In silico drug safety and efficacy Symposium	2019-05-29
2018	Laura OrdovÃ¡s, Aida OlivÃ¡n-Viguera, Estel Ramos, Laura GarcÃa-MendÃvil, Esther Pueyo Chunk isolation of adult pig cardiomyocytes for electrophysiological, histological and molecular studies published pages: , ISSN: 1664-042X, DOI:	Frontiers in Physiology To be submitted	2019-05-29
2018	Michael P. Gilbey, Esther Pueyo, Peter Taggart The kinetic behavior of sympathetic nerve activity as an arrhythmogenic mechanism published pages: , ISSN: 2041-1723, DOI:	Nature Communications To be submitted	2019-05-29
2018	David A. Sampedro, JesÃºs Fernandez-Bes, Esther Pueyo Characterization of individual cardiac cell properties and dynamic states by nonlinear filtering methods published pages: , ISSN: 1007-5704, DOI:	Communications in Nonlinear Science and Numerical Simulations To be submitted	2019-05-29
2018	David Adolfo Sampedro-Puente, Jesus Fernandez-Bes, LÃ¡szlÃ³ VirÃ¡g, AndrÃ¡s VarrÃ³, Esther Pueyo Data-driven Identification of Stochastic Model Parameters and State Variables: Application to theStudy of Cardiac Beat-to-beat Variability published pages: , ISSN: 0018-9294, DOI:	IEEE Transactions on Biomedical and Health Informatics Under review	2019-05-29
2016	JosÃ© Vicente Ruiz, David G. Strauss (Supervisor), Esther Pueyo (Supervisor) Novel electrocardiographic biomarkers for proarrhythmic assessment of drugs published pages: , ISSN: , DOI:	Doctoral Thesis	2019-05-29
2018	Juan Bolea, Raquel BailÃ³n, Esther Pueyo On the Standardization of Approximate Entropy: Multidimensional Approximate Entropy Index Evaluated on Short-Term HRV Time Series published pages: 1-15, ISSN: 1076-2787, DOI: 10.1155/2018/4953273	Complexity 2018	2019-05-29
2017	Julia RamÃrez, Esther Pueyo (Supervisor), Pablo Laguna (Supervisor) Prediction of Cardiac Death Risk by Analysis of Ventricular Repolarization Restitution from the Electrocardiogram Signal published pages: , ISSN: 2254-7606, DOI:	Doctoral Thesis	2019-05-29
2017	JesÃºs Carro, JosÃ© F. RodrÃguez-Matas, Violeta Monasterio, Esther Pueyo Limitations in electrophysiological model development and validation caused by differences between simulations and experimental protocols published pages: 53-64, ISSN: 0079-6107, DOI: 10.1016/j.pbiomolbio.2016.11.006	Progress in Biophysics and Molecular Biology 129	2019-05-29
2017	JesÃºs Carro, JosÃ© F RodrÃguez-Matas, Esther Pueyo A Methodology to Improve Human Ventricular Models for the Investigation of Cardiac Arrhythmias published pages: 403a, ISSN: 0006-3495, DOI: 10.1016/j.bpj.2016.11.2183	Biophysical Journal 112/3	2019-05-29
2016	E. Pueyo, C. E. Dangerfield, O. J. Britton, L. VirÃ¡g, K. KistamÃ¡s, N. SzentandrÃ¡ssy, N. Jost, A. VarrÃ³, P. P. NÃ¡nÃ¡si, K. Burrage, B. RodrÃguez Experimentally-Based Computational Investigation into Beat-To-Beat Variability in Ventricular Repolarization and Its Response to Ionic Current Inhibition published pages: e0151461, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0151461	PLOS ONE 11/3	2019-05-29
2018	Estel Ramos-MarquÃ¨s, Laura GarcÃa-Mendivil, Juan Carlos Oliveros, Rafael Torres-PÃ©rez, Aida Olivan-Viguera, Laura OrdovÃ¡s, Esther Pueyo Analysis of the role of microRNA in age-related heart electrophysiological remodeling published pages: , ISSN: , DOI:	Cell Symposia Aging and Metabolism 2018 Abstract submission	2019-05-29
2016	Juan Bolea, Esther Pueyo, Michele Orini, Raquel BailÃ³n Influence of Heart Rate in Non-linear HRV Indices as a Sampling Rate Effect Evaluated on Supine and Standing published pages: 00501(12pp), ISSN: 1664-042X, DOI: 10.3389/fphys.2016.00501	Frontiers in Physiology 7	2019-05-29
2018	Esther Pueyo Characterization of abnormal cardiac dynamics in aged and failing hearts: insights from experimental and computational research published pages: , ISSN: , DOI:	QBIO IV 2018	2019-05-29
2018	JesÃºs Carro, JosÃ© F. RodrÃguez (Supervisor), Esther Pueyo (Supervisor) New methodologies for the development and validation of cardiac electrophysiological models published pages: , ISSN: , DOI:	Doctoral Thesis	2019-05-29
2020	Laura GarcÃa, Laura OrdovÃ¡s (Supervisor), Esther Pueyo (Supervisor) In silico and in vitro modeling of cardiac aging for cardiovascular disease prevention published pages: , ISSN: , DOI:	Doctoral Thesis	2019-05-29
2016	Esther Pueyo, Michele Orini, JosÃ© F. RodrÃguez, Peter Taggart Interactive effect of beta-adrenergic stimulation and mechanical stretch on low-frequency oscillations of ventricular action potential duration in humans published pages: 93-105, ISSN: 0022-2828, DOI: 10.1016/j.yjmcc.2016.05.003	Journal of Molecular and Cellular Cardiology 97	2019-05-29
2018	Pablo V. Gracia, Esther Pueyo (Supervisor) Characterization of the contribution of electrical, structural and autonomic factors to atrial fibrillation published pages: , ISSN: , DOI:	Doctoral Thesis	2019-05-29
2016	Pablo Laguna, Juan Pablo Martinez Cortes, Esther Pueyo Techniques for Ventricular Repolarization Instability Assessment From the ECG published pages: 392-415, ISSN: 0018-9219, DOI: 10.1109/JPROC.2015.2500501	Proceedings of the IEEE 104/2	2019-05-29
2018	Eleonora Grandi, Stefano Morotti, Esther Pueyo, Blanca RodrÃguez Getting to the Heart of Safety Pharmacology published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2018.00678	Frontiers in Physiology	2019-05-29
2018	David Adolfo Sampedro-Puente, JesÃºs FernÃ¡ndez-Bes, Bradley Porter, Stefan Van Duijvenboden, Peter Taggart, Esther Pueyo Mechanisms underlying interactions between low-frequency oscillations and beat-to-beat repolarization variability during sympathetic provocation. Implications for arrhythmogenesis published pages: , ISSN: 1664-042X, DOI:	Frontiers in Physiology To be submitted	2019-05-29
2017	Julia Ramirez, Michele Orini, J. Derek Tucker, Esther Pueyo, Pablo Laguna Variability of Ventricular Repolarization Dispersion Quantified by Time-Warping the Morphology of the T-Waves published pages: 1619-1630, ISSN: 0018-9294, DOI: 10.1109/TBME.2016.2614899	IEEE Transactions on Biomedical Engineering 64/7	2019-05-29
2018	JesÃºs Carro, Esther Pueyo, JosÃ© F. RodrÃguez Matas A response surface optimization approach to adjust ionic current conductances of cardiac electrophysiological models. Application to the study of potassium level changes published pages: e0204411, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0204411	PLOS ONE 13/10	2019-05-29
2018	Laura GarcÃa-MendÃvil, Estel Ramos-MarquÃ¨s, Juan Carlos Oliveros, Rafael Torres-PÃ©rez, JesÃºs FernÃ¡ndez-Bes, Aida Olivan-Viguera, Esther Pueyo, Laura OrdovÃ¡s Transcriptional analysis of human cardiac aging by chronological and biological age published pages: , ISSN: , DOI:	Cell Symposia Aging and Metabolism 2018 Abstract submission	2019-05-29
2019	David Sampedro, Esther Pueyo (Supervisor) Theoretical analysis of the effects of the Autonomic Nervous System on human cardiac electrophysiology and its relation to arrhythmic risk published pages: , ISSN: , DOI:	Doctoral Thesis	2019-05-29
2018	David A. Sampedro, JesÃºs Fernandez-Bes, Bradley Porter, Stefan Van Duijvenboden, Peter Taggart, Esther Pueyo Mechanisms underlying interactions between low-frequency oscillations and beat-to-beat repolarization variability in the human ventricles undersympathetic provocation published pages: , ISSN: , DOI:	42nd European Working Group on Cardiac Cellular Electrophysiology Annual Meeting	2019-05-29
2016	Jose Vicente, Lars Johannesen, Meisam Hosseini, Jay W. Mason, Philip T. Sager, Esther Pueyo, David G. Strauss Electrocardiographic Biomarkers for Detection of Drug-Induced Late Sodium Current Block published pages: e0163619, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0163619	PLOS ONE 11/12	2019-05-29
2018	David A. Sampedro, JesÃºs Fernandez-Bes, Bradley Porter, Stefan Van Duijvenboden, Peter Taggart, Esther Pueyo Mechanisms underlying interactions between low-frequency oscillations and beat-to-beat repolarization variability under sympathetic provocation published pages: , ISSN: , DOI:	Virtual Physiological Human 2018	2019-05-29
2017	Julia RamÃrez, Michele Orini, Ana MincholÃ©, Violeta Monasterio, Iwona Cygankiewicz, Antonio BayÃ©s de Luna, Juan Pablo MartÃnez, Esther Pueyo, Pablo Laguna Tâ€Wave Morphology Restitution Predicts Sudden Cardiac Death in Patients With Chronic Heart Failure published pages: e005310, ISSN: 2047-9980, DOI: 10.1161/JAHA.116.005310	Journal of the American Heart Association 6/5	2019-05-29
2017	michele orini, Esther Pueyo, Pablo Laguna, Raquel Bailon A Time-Varying Non-Parametric Methodology for Assessing Changes in QT Variability Unrelated to Heart Rate Variability published pages: 1-1, ISSN: 0018-9294, DOI: 10.1109/TBME.2017.2758925	IEEE Transactions on Biomedical Engineering	2019-05-29
2018	Juan Bolea, Raquel BailÃ³n (Supervisor), Esther Pueyo (Supervisor) Time-frequency analysis of heart rate variability for characterization of autonomic impairments published pages: , ISSN: , DOI:	Doctoral Thesis	2019-05-29
2018	Aida Olivan-Viguera, Angel Luis Garcia-Otin, Javier Lozano-Gerona, Edgar Abarca-Lachen, Ana J. Garcia-Malinis, Kirk L. Hamilton, Yolanda Gilaberte, Esther Pueyo, Ralf KÃ¶hler Pharmacological activation of TRPV4 produces immediate cell damage and induction of apoptosis in human melanoma cells and HaCaT keratinocytes published pages: e0190307, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0190307	PLOS ONE 13/1	2019-05-29
2018	Estel Ramos, Laura OrdovÃ¡s, Laura GarcÃa-MendÃvil, Rafael Torres-PÃ©rez, Juan Carlos Oliveros, Aida OlivÃ¡n-Viguera, Esther Pueyo Deciphering the role of key microRNAs involved in regulating electro-mechanical left ventricular function during the course of aging published pages: , ISSN: 0009-7322, DOI:	Circulation: Genomics and Precision Medicine To be submitted	2019-05-29
2017	JesÃºs Carro, JosÃ© F. RodrÃguez, Esther Pueyo Multiscale Methods for Definition of Ionic Variables in Electrophysiological Models published pages: 123, ISSN: , DOI:	EMBEC\'17 & NBC\'17	2019-05-29
2018	Julia RamÃrez, Michele Orini, Ana MincholÃ©, Violeta Monasterio, Iwona Cygankiewicz, Antonio BayÃ©s de Luna, Juan Pablo MartÃnez, Esther Pueyo, Pablo Laguna Correction: Tâ€Wave Morphology Restitution Predicts Sudden Cardiac Death in Patients With Chronic Heart Failure published pages: , ISSN: 2047-9980, DOI:	Journal of the American Heart Association	2019-04-25
2018	JesÃºs Carro, JosÃ© F. RodrÃguez-Matas, Violeta Monasterio, Esther Pueyo Corrigendum to â€œLimitations in electrophysiological model development and validation caused by differences between simulations and experimental protocolsâ€ [Prog. Biophys. Mol. Biol. 129 (2017) 53â€“64] published pages: , ISSN: 0079-6107, DOI: 10.1016/j.pbiomolbio.2018.11.001	Progress in Biophysics and Molecular Biology	2019-04-25
2018	Juan Bolea, Esther Pueyo, Michele Orini, Raquel BailÃ³n Corrigendum: Influence of Heart Rate in Non-linear HRV Indices as a Sampling Rate Effect Evaluated on Supine and Standing published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2018.00620	Frontiers in Physiology 9	2019-04-25
2018	Esther Pueyo La ingenierÃa como herramienta para combatir las enfermedades cardiovasculares published pages: , ISSN: , DOI:	Congreso de IngenierÃa Hospitalaria	2019-04-25
2018	Esther Pueyo Understanding heart function through combined clinical, experimental and computational research published pages: , ISSN: , DOI:	Virtual Physiological Human Summer School 2018	2019-04-25
2018	Esther Pueyo My ERC experience published pages: , ISSN: , DOI:	Virtual Physiological Human 2018	2019-04-25
2018	Jose Vicente, Lars Johannesen, Meisam Hosseini, Jay W. Mason, Philip T. Sager, Esther Pueyo, David G. Strauss Correction: Electrocardiographic Biomarkers for Detection of Drug-Induced Late Sodium Current Block published pages: e0197952, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0197952	PLOS ONE 13/5	2019-04-25
2018	E. Pueyo, C. E. Dangerfield, O. J. Britton, L. VirÃ¡g, K. KistamÃ¡s, N. SzentandrÃ¡ssy, N. Jost, A. VarrÃ³, P. P. NÃ¡nÃ¡si, K. Burrage, B. RodrÃguez Correction: Experimentally-Based Computational Investigation into Beat-To-Beat Variability in Ventricular Repolarization and Its Response to Ionic Current Inhibition published pages: e0197871, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0197871	PLOS ONE 13/5	2019-04-25
2018	David A. Sampedro-Puente, Laura GarcÃa-MendÃvil, Estel Ramos-MarquÃ¨s, Aida Olivan-Viguera, JesÃºs Fernandez-Bes, Laura Ordovas, Eesther Pueyo Cardiac dynamics and arrhythmic risk in aged and failing hearts: insights from experimental and computational research published pages: , ISSN: , DOI:	Virtual Physiological Human 2018	2019-04-25
2018	Esther Pueyo, Michele Orini, JosÃ© F. RodrÃguez, Peter Taggart Corrigendum to â€œInteractive effect of beta-adrenergic stimulation and mechanical stretch on low-frequency oscillations of ventricular action potential duration in humansâ€ [J. Mol. Cell. Cardiol. 97 (2016) 93â€“105] published pages: 305, ISSN: 0022-2828, DOI: 10.1016/j.yjmcc.2018.05.006	Journal of Molecular and Cellular Cardiology 121	2019-04-25

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