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Chromatin3D SIGNED

Chromatin Dynamics in Development and Disease

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

Chromatin3D project word cloud

Explore the words cloud of the Chromatin3D project. It provides you a very rough idea of what is the project "Chromatin3D" about.

assembling implicated stable destabilization developmental focal cross mechanisms gene territories enriched dynamics disease occupy exchange responsible stability modification put maintained cancer onto initiated group ordered proteins nucleus physiological expertise multidisciplinary genome histone structures nuclear contains replication dynamic insights disciplinary transcription pathologies organizing organization rapid questions assembly dna components scientists onset mechanistic kinetics academia molecular cell membranes binding deregulation found discrete chromosomes rna assemble least absence chromatin compartmentalized cellular structure chromosomal question industry regulating regulatory act lacks

Project "Chromatin3D" data sheet

The following table provides information about the project.

Coordinator	IDRYMA TECHNOLOGIAS KAI EREVNAS Organization address address: N PLASTIRA STR 100 city: IRAKLEIO postcode: 70013 website: www.forth.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Greece [EL]
Project website	http://www.chromatin3d.eu/
Total cost	3˙782˙583 €
EC max contribution	3˙782˙583 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2014
Funding Scheme	MSCA-ITN-ETN
Starting year	2015
Duration (year-month-day)	from 2015-01-01 to 2018-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	IDRYMA TECHNOLOGIAS KAI EREVNAS IDRYMA TECHNOLOGIAS KAI EREVNAS Organization address address: N PLASTIRA STR 100 city: IRAKLEIO postcode: 70013 website: www.forth.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (IRAKLEIO)	coordinator	969˙547.00
2	KAROLINSKA INSTITUTET KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	participant	527˙318.00
3	AvantiCell Science Ltd AvantiCell Science Ltd Organization address address: GIBBSYARD BUILDING city: AYR postcode: KA6 5HW website: www.avanticell.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (AYR)	participant	273˙287.00
4	THE UNIVERSITY OF EDINBURGH THE UNIVERSITY OF EDINBURGH Organization address address: OLD COLLEGE, SOUTH BRIDGE city: EDINBURGH postcode: EH8 9YL website: www.ed.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (EDINBURGH)	participant	273˙287.00
5	WEIZMANN INSTITUTE OF SCIENCE WEIZMANN INSTITUTE OF SCIENCE Organization address address: HERZL STREET 234 city: REHOVOT postcode: 7610001 website: www.weizmann.ac.il contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (REHOVOT)	participant	260˙300.00
6	DIAGENODE DIAGENODE Organization address address: RUE DU BOIS SAINT JEAN 3 LIEGE PARK SCIENCE city: SERAING postcode: 4102 website: www.diagenode.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (SERAING)	participant	250˙560.00
7	LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN Organization address address: GESCHWISTER SCHOLL PLATZ 1 city: MUENCHEN postcode: 80539 website: www.uni-muenchen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	participant	249˙216.00
8	MOSAIQUES DIAGNOSTICS GMBH MOSAIQUES DIAGNOSTICS GMBH Organization address address: ROTENBURGER STRASSE 20 city: HANNOVER postcode: 30659 website: www.mosaiques-diagnostics.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HANNOVER)	participant	249˙216.00
9	FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE Organization address address: AVENIDA GRAN VIA HOSPITALET 199-203 city: L'HOSPITALET DE LLOBREGAT postcode: 8908 website: www.idibell.cat contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (L'HOSPITALET DE LLOBREGAT)	participant	247˙872.00
10	UD-GENOMED MEDICAL GENOMIC TECHNOLOGIES KUTATAS-FEJLESZTESI ES SZOLGALTATO KFT UD-GENOMED MEDICAL GENOMIC TECHNOLOGIES KUTATAS-FEJLESZTESI ES SZOLGALTATO KFT Organization address address: NAGYERDEI KRT 98 city: DEBRECEN postcode: 4032 website: www.ud-genomed.hu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	HU (DEBRECEN)	participant	223˙913.00
11	FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA Organization address address: VIA MOREGO 30 city: GENOVA postcode: 16163 website: www.iit.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (GENOVA)	participant	164˙872.00
12	ISTITUTO EUROPEO DI ONCOLOGIA SRL ISTITUTO EUROPEO DI ONCOLOGIA SRL Organization address address: Via Filodrammatici 10 city: MILANO postcode: 20121 website: www.ieo.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	participant	93˙188.00
13	BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING Organization address address: FLEMING STREET 34 city: VARI-ATHENS postcode: 16672 website: www.fleming.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (VARI-ATHENS)	participant	0.00
14	EXIQON AS EXIQON AS Organization address address: BYGSTUBBEN 9 city: VEDBAEK postcode: 2950 website: http://www.exiqon.com/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (VEDBAEK)	partner	0.00
15	LIFEGLIMMER GMBH LIFEGLIMMER GMBH Organization address address: MARKELSTRASSE 38 city: BERLIN postcode: 12163 website: www.lifeglimmer.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BERLIN)	partner	0.00
16	SB Science Management UG SB Science Management UG Organization address address: MUTHESIUSSTR 11 city: BERLIN postcode: 12163 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BERLIN)	partner	0.00
17	YELLOW RESEARCH YELLOW RESEARCH Organization address address: HERENGRACHT 495 city: AMSTERDAM postcode: 1017BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	partner	0.00

Map

Project objective

The cell nucleus is organized and compartmentalized into a highly ordered structure that contains DNA, RNA, chromosomal and histone proteins which make up a structure called chromatin. The dynamics associated with these various components are responsible for regulating physiological processes and the overall stability of the genome. The destabilization of such regulatory mechanisms that act on the chromatin structure are implicated in pathologies such as cancer. Higher order organization of chromatin results in chromosomes which occupy discrete territories within the cell nucleus. Most nuclear processes occur or at least being initiated onto the chromosomes which makes them the main organizing factors in the nucleus. Several proteins that are involved in the replication of DNA, gene transcription and the processing of RNA are found enriched in discrete focal structures. An emerging question is how these structures assemble and are maintained in the absence of membranes and moreover what are the kinetics of stable binding and/or rapid exchange of their components. The dynamic assembly and modification of chromatin during developmental processes as well as the deregulation of such chromatin dynamics during the onset of disease lacks mechanistic insights at present. To address these questions we have put forward a multidisciplinary approach which involves molecular, cellular and systems level approaches by assembling a group of scientists from academia and industry with cross disciplinary expertise and capabilities.

Deliverables

List of deliverables.
I. Scientific writing and presentation course	Other	2020-03-17 11:29:12
Podcasts & Videocasts	Websites, patent fillings, videos etc.	2020-03-17 11:29:11
Visits and secondments of ESRs	Other	2020-03-17 11:29:11
Workshop 4: â€œEpigenetic modifiers and genome integrityâ€	Other	2020-03-17 11:29:12
Bioethics Course	Other	2020-03-17 11:29:11
Final Network Conference	Other	2020-03-17 11:29:12
Attendance of ESRs in international conferences & symposia	Other	2020-03-17 11:29:11
Workshop 2: â€œCancer Epigenomicsâ€	Other	2020-03-17 11:29:11
Business and entrepreneurship course	Other	2020-03-17 11:29:11
Workshop 3: â€œDevelopmental Programming and Reprogrammingâ€	Other	2020-03-17 11:29:11
Project Management course	Other	2020-03-17 11:29:09
1st Chromatin3D Summer School	Other	2020-03-17 11:29:09
Open Lab Day	Other	2020-03-17 11:29:09
Workshop 1: â€œFolding chromatin in Three Dimensionsâ€	Other	2020-03-17 11:29:09
Facebook Chromatin3D page	Websites, patent fillings, videos etc.	2020-03-17 11:29:09
Chromatin3D Newsletter	Websites, patent fillings, videos etc.	2020-03-17 11:29:10
Communication course	Other	2020-03-17 11:29:09
Recruitment of ESRs	Other	2020-03-17 11:29:09
Chromatin3D website	Websites, patent fillings, videos etc.	2020-03-17 11:29:09
International Course on Laboratory Animal Science	Other	2020-03-17 11:29:09

Take a look to the deliverables list in detail: detailed list of Chromatin3D deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Pierbruno Ricci, Pedro MagalhÃ£es, Magdalena Krochmal, Martin Pejchinovski, Erica Daina, Maria Rosa Caruso, Laura Goea, Iwona Belczacka, Giuseppe Remuzzi, Muriel Umbhauer, Jens Drube, Lars Pape, Harald Mischak, StÃ©phane Decramer, Franz Schaefer, Joost P. Schanstra, Silvia Cereghini, Petra ZÃ¼rbig Urinary proteome signature of Renal Cysts and Diabetes syndrome in children published pages: 9:2225, ISSN: 2045-2322, DOI: 10.1038/s41598-019-38713-5	Scientific Reports 9/1	2020-03-17
2018	Zelenka T. ProstorovÃ¡ organizace chromatinu (3D chromatin organization) published pages: VesmÃr 97, 34, , ISSN: , DOI:	VESMIR VesmÃr 97, 34, 2018/1	2020-03-17
2019	David Marx, Jochen Metzger, JÃ©rÃ´me Olagne, Iwona Belczacka, Stanislas Faguer, Magali Colombat, Holger Husi, William Mullen, Wilfried Gwinner, Sophie Caillard Proteomics in Kidney Allograft Transplantation-Application of Molecular Pathway Analysis for Kidney Allograft Disease Phenotypic Biomarker Selection published pages: 1800091, ISSN: 1862-8346, DOI: 10.1002/prca.201800091	PROTEOMICS - Clinical Applications 1800091C	2020-03-17
2018	Iwona Belczacka, Martin Pejchinovski, Magdalena Krochmal, Pedro MagalhÃ£es, Maria Frantzi, William Mullen, Antonia Vlahou, Harald Mischak, Vera Jankowski Urinary Glycopeptide Analysis for the Investigation of Novel Biomarkers published pages: 1800111, ISSN: 1862-8346, DOI: 10.1002/prca.201800111	PROTEOMICS - Clinical Applications 18 October 2018	2020-03-17
2018	Daphna Rothschild, Omer Weissbrod, Elad Barkan, Alexander Kurilshikov, Tal Korem, David Zeevi, Paul I. Costea, Anastasia Godneva, Iris N. Kalka, Noam Bar, Smadar Shilo, Dar Lador, Arnau Vich Vila, Niv Zmora, Meirav Pevsner-Fischer, David Israeli, Noa Kosower, Gal Malka, Bat Chen Wolf, Tali Avnit-Sagi, Maya Lotan-Pompan, Adina Weinberger, Zamir Halpern, Shai Carmi, Jingyuan Fu, Cisca Wijmenga, Alexandra Zhernakova, Eran Elinav, Eran Segal Environment dominates over host genetics in shaping human gut microbiota published pages: 210-215, ISSN: 0028-0836, DOI: 10.1038/nature25973	Nature 555/7695	2020-03-17
2018	Stavros Bashiardes, Anastasia Godneva, Eran Elinav, Eran Segal Towards utilization of the human genome and microbiome for personalized nutrition published pages: 57-63, ISSN: 0958-1669, DOI: 10.1016/j.copbio.2017.11.013	Current Opinion in Biotechnology 51	2020-03-17
2018	David Marx, Jochen Metzger, Martin Pejchinovski, Ryan Bruce Gil, Maria Frantzi, Agnieszka Latosinska, Iwona Belczacka, Silke Sophie Heinzmann, Holger Husi, Jerome Zoidakis, Matthias Klingele, Stefan Herget-Rosenthal Proteomics and Metabolomics for AKI Diagnosis published pages: 63-87, ISSN: 0270-9295, DOI: 10.1016/j.semnephrol.2017.09.007	Seminars in Nephrology 38/1	2020-03-17
2018	David J. Hanly, Manel Esteller, MarÃa Berdasco Interplay between long non-coding RNAs and epigenetic machinery: emerging targets in cancer? published pages: 20170074, ISSN: 0962-8436, DOI: 10.1098/rstb.2017.0074	Philosophical Transactions of the Royal Society B: Biological Sciences 373/1748	2020-03-17
2017	Iwona Belczacka, Agnieszka Latosinska, Jochen Metzger, David Marx, Antonia Vlahou, Harald Mischak, Maria Frantzi Proteomics biomarkers for solid tumors: Current status and future prospects published pages: 49-78, ISSN: 0277-7037, DOI: 10.1002/mas.21572	Mass Spectrometry Reviews 38/1	2020-03-17
2019	Zeevi, D., Korem T., Godneva, A., Bar, N. ,Segal, E Structural variation in the gut microbiome associates with host health published pages: , ISSN: 1476-4687, DOI: 10.1038/s41586-019-1065-y	Nature 27 March 2019	2020-03-17
2018	1) Belczacka I, Latosinska A, Frantzi M, and Harald Mischak H. â€œUrinary CE-MS Peptide Marker Pattern for Detection of Solid Tumors â€“ Beyond the Abstractâ€ published pages: May 10 2018, ISSN: , DOI:	UROTODAY May 10 2018	2020-03-17
2018	Maria Frantzi, Agnieszka Latosinska, Iwona Belczacka, Harald Mischak Urinary proteomic biomarkers in oncology: ready for implementation? published pages: 49-63, ISSN: 1478-9450, DOI: 10.1080/14789450.2018.1547193	Expert Review of Proteomics 16/1	2020-03-17
2018	Zsolt Czimmerer, Attila Horvath, Bence Daniel, Gergely Nagy, Ixchelt Cuaranta-Monroy, Mate Kiss, Zsuzsanna Kolostyak, Szilard Poliska, Laszlo Steiner, Nikolas Giannakis, Tamas Varga, Laszlo Nagy Dynamic transcriptional control of macrophage miRNA signature via inflammation responsive enhancers revealed using a combination of next generation sequencing-based approaches published pages: 14-28, ISSN: 1874-9399, DOI: 10.1016/j.bbagrm.2017.11.003	Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1861/1	2020-03-17
2018	Iwona Belczacka, Agnieszka Latosinska, Justyna Siwy, Jochen Metzger, Axel S. Merseburger, Harald Mischak, Antonia Vlahou, Maria Frantzi, Vera Jankowski Urinary CE-MS peptide marker pattern for detection of solid tumors published pages: 8:5227, ISSN: 2045-2322, DOI: 10.1038/s41598-018-23585-y	Scientific Reports 8/1	2020-03-17
2019	Attila Horvath, Bence Daniel, Lajos Szeles, Ixchelt Cuaranta-Monroy, Zsolt Czimmerer, Lilla Ozgyin, Laszlo Steiner, Mate Kiss, Zoltan Simandi, Szilard Poliska, Nikolas Giannakis, Emanuele Raineri, Ivo G Gut, Benedek Nagy, Laszlo Nagy Labelled regulatory elements are pervasive features of the macrophage genome and are dynamically utilized by classical and alternative polarization signals published pages: 2019 1, ISSN: 0305-1048, DOI: 10.1093/nar/gkz118	Nucleic Acids Research 2019 1	2020-03-17
2017	Alessandro Scacchetti, Laura Brueckner, Dhawal Jain, Tamas Schauer, Xu Zhang, Frank Schnorrer, Bas van Steensel, Tobias Straub, Peter B Becker CHRAC/ACF contribute to the repressive ground state of chromatin published pages: e201800024, ISSN: 2575-1077, DOI: 10.26508/lsa.201800024	Life Science Alliance 1/1	2020-03-17
2016	Stratigi K, Chatzidoukaki O, Garinis GA. DNA damage-induced inflammation and nuclear architecture published pages: , ISSN: 0047-6374, DOI: 10.1016/j.mad.2016.09.008	Mechanisms of Ageing and Development	2020-03-17

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The information about "CHROMATIN3D" are provided by the European Opendata Portal: CORDIS opendata.