Explore the words cloud of the ADIPOA2 project. It provides you a very rough idea of what is the project "ADIPOA2" about.
The following table provides information about the project.
Coordinator |
NATIONAL UNIVERSITY OF IRELAND GALWAY
Organization address contact info |
Coordinator Country | Ireland [IE] |
Project website | http://adipoa2.eu/ |
Total cost | 5˙999˙000 € |
EC max contribution | 5˙999˙000 € (100%) |
Programme |
1. H2020-EU.3.1.3. (Treating and managing disease) |
Code Call | H2020-PHC-2014-single-stage |
Funding Scheme | RIA |
Starting year | 2015 |
Duration (year-month-day) | from 2015-01-01 to 2019-12-31 |
Take a look of project's partnership.
Osteoarthritis (OA) is an incurable disease that has evaded pharmacological interference, biologic therapy or surgical intervention to prevent disease progression. Currently, OA is designated the 11th highest contributor (of 291 diseases) of global disability. In the absence of effective treatment options, cellular therapies using mesenchymal stem/stromal cells (MSCs) have emerged as potential candidates to overcome this clinical short-coming. Autologous adipose-derived mesenchymal stromal cells (ASCs) are attractive for cellular therapy given the abundance of tissue, high frequency of MSCs and minimally invasive harvest procedure. The EU consortium ADIPOA has shown in a ‘first in man’ 2-centre Phase I safety study that intraarticular injection of a single dose of autologous ASCs to the knee (18 patients, 12 month follow-up) was well-tolerated, had no adverse effects, and resulted in an improvement in pain score and functional outcome. ADIPOA2 will deliver a large-scale clinical trial in regenerative medicine for OA. The purpose of the project is to design and implement a phase IIb study to assess the safety and efficacy of autologous (patient-derived) ACSs in the treatment of advanced OA of the knee. The cells will be prepared from samples of adipose tissue harvested from patients by lipoaspiration. ADIPOA2 will comprise a multi-centre, randomized clinical trial comparing culture-expanded, autologous adult ASCs in subjects with knee OA with another widely used therapeutic approach for knee degeneration (injection of Hyaluronan). There are two large elements of the study: (1) the production of consistent batches of high-quality autologous ASCs under GMP-compliant conditions and (2) delivery of these cell doses to patients in a trial which will meet all national and European regulatory and ethical standards and which will have sufficient statistical power to provide an unambiguous and definitive assessment of safety and efficacy.
Website | Other | 2020-02-26 14:33:22 |
Patient Information Templates | Documents, reports | 2020-02-26 14:33:22 |
Take a look to the deliverables list in detail: detailed list of ADIPOA2 deliverables.
year | authors and title | journal | last update |
---|---|---|---|
2019 |
Stephanie C. M. van Dalen, Arjen B. Blom, Birgitte Walgreen, Annet W. Slöetjes, Monique M. A. Helsen, Edwin J. W. Geven, Menno ter Huurne, Thomas Vogl, Johannes Roth, Fons A. J. van de Loo, Marije I. Koenders, Louis Casteilla, Peter M. van der Kraan, Martijn H. J. van den Bosch, Peter L. E. M. van Lent IL-1β-Mediated Activation of Adipose-Derived Mesenchymal Stromal Cells Results in PMN Reallocation and Enhanced Phagocytosis: A Possible Mechanism for the Reduction of Osteoarthritis Pathology published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.01075 |
Frontiers in Immunology 10 | 2020-02-26 |
2019 |
Cristina Manferdini, Francesca Paolella, Elena Gabusi, Luca Cattini, Markus Rojewski, Hubert Schrezenmeier, Olga Addimanda, Riccardo Meliconi, Gina Lisignoli Osteoarthritic Milieu Affects Adiposeâ€Derived Mesenchymal Stromal Cells published pages: , ISSN: 0736-0266, DOI: 10.1002/jor.24446 |
Journal of Orthopaedic Research | 2020-02-26 |
2018 |
Stella Cosenza, Karine Toupet, Marie Maumus, Patricia Luz-Crawford, Olivier Blanc-Brude, Christian Jorgensen, Danièle Noël Mesenchymal stem cells-derived exosomes are more immunosuppressive than microparticles in inflammatory arthritis published pages: 1399-1410, ISSN: 1838-7640, DOI: 10.7150/thno.21072 |
Theranostics 8/5 | 2020-02-26 |
2017 |
Schrezenmeier, Hubert Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaften für Hämatologie und Medizinische Onkologie, Stuttgart, 29. September-3. Oktober 2017: Abstracts published pages: 1-308, ISSN: 2296-5270, DOI: 10.1159/000479566 |
Oncology Research and Treatment 40/3 | 2020-02-26 |
2017 |
Schrezenmeier, Hubert 50. Jahrestagung der Deutschen Gesellschaft für Transfusionsmedizin und Immunhämatologie (DGTI), Köln, 24.-27. Oktober 2017, Abstracts published pages: 1-94, ISSN: 1660-3796, DOI: 10.1159/000481444 |
Transfusion Medicine and Hemotherapy 44/1 | 2020-02-26 |
2017 |
Schrezenmeier, Hubert 50. Jahrestagung der Deutschen Gesellschaft für Transfusionsmedizin und Immunhämatologie (DGTI), Köln, 24.-27. Oktober 2017, Abstracts published pages: 1-94, ISSN: 1660-3796, DOI: 10.1159/000481444 |
Transfusion Medicine and Hemotherapy 44/1 | 2020-02-26 |
2016 |
M. H. van den Bosch, A. B. Blom, R. F. Schelbergen, M. I. Koenders, F. A. van de Loo, W. B. van den Berg, T. Vogl, J. Roth, P. M. van der Kraan, P. L. van Lent Alarmin S100A9 Induces Proinflammatory and Catabolic Effects Predominantly in the M1 Macrophages of Human Osteoarthritic Synovium published pages: 1874-1884, ISSN: 0315-162X, DOI: 10.3899/jrheum.160270 |
The Journal of Rheumatology 43/10 | 2020-02-26 |
2017 |
Marie Maumus, Cristina Manferdini, Karine Toupet, Paul Chuchana, Louis Casteilla, Mélanie Gachet, Christian Jorgensen, Gina Lisignoli, Danièle Noël Thrombospondin-1 Partly Mediates the Cartilage Protective Effect of Adipose-Derived Mesenchymal Stem Cells in Osteoarthritis published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2017.01638 |
Frontiers in Immunology 8 | 2020-02-26 |
2017 |
Schrezenmeier, Hubert Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaften für Hämatologie und Medizinische Onkologie, Stuttgart, 29. September-3. Oktober 2017: Abstracts published pages: 1-308, ISSN: 2296-5270, DOI: 10.1159/000479566 |
Oncology Research and Treatment 40/3 | 2020-02-26 |
2014 |
R.F. Schelbergen, S. van Dalen, M. ter Huurne, J. Roth, T. Vogl, D. Noël, C. Jorgensen, W.B. van den Berg, F.A. van de Loo, A.B. Blom, P.L.E.M. van Lent Treatment efficacy of adipose-derived stem cells in experimental osteoarthritis is driven by high synovial activation and reflected by S100A8/A9 serum levels published pages: 1158-1166, ISSN: 1063-4584, DOI: 10.1016/j.joca.2014.05.022 |
Osteoarthritis and Cartilage 22/8 | 2020-02-26 |
2016 |
Yves-Marie Pers, Lars Rackwitz, Rosanna Ferreira, Oliver Pullig, Christophe Delfour, Frank Barry, Luc Sensebe, Louis Casteilla, Sandrine Fleury, Philippe Bourin, Danièle Noël, François Canovas, Catherine Cyteval, Gina Lisignoli, Joachim Schrauth, Daniel Haddad, Sophie Domergue, Ulrich Noeth, Christian Jorgensen Adipose Mesenchymal Stromal Cell-Based Therapy for Severe Osteoarthritis of the Knee: A Phase I Dose-Escalation Trial published pages: 847-856, ISSN: 2157-6564, DOI: 10.5966/sctm.2015-0245 |
STEM CELLS Translational Medicine 5/7 | 2020-02-26 |
2017 |
Stella Cosenza, Maxime Ruiz, Marie Maumus, Christian Jorgensen, Danièle Noël Pathogenic or Therapeutic Extracellular Vesicles in Rheumatic Diseases: Role of Mesenchymal Stem Cell-Derived Vesicles published pages: 889, ISSN: 1422-0067, DOI: 10.3390/ijms18040889 |
International Journal of Molecular Sciences 18/12 | 2020-02-26 |
2016 |
Cattini, Luca; Silvestri, Ylenia; Gambari, Laura; Filardo, Giuseppe; Paolella, Francesca; Gabusi, Elena; Fleury-Cappellesso, Sandrine; Manferdini, Cristina; Lisignoli, Gina From osteoarthritic synovium to synovial-derived cells characterization: synovial macrophages are key effector cells published pages: , ISSN: 1478-6362, DOI: 10.1186/s13075-016-0983-4 |
Arthritis Research & Therapy 1 | 2020-02-26 |
2015 |
Rita Vicente, Danièle Noël, Yves-Marie Pers, Florence Apparailly, Christian Jorgensen Deregulation and therapeutic potential of microRNAs in arthritic diseases published pages: 211-220, ISSN: 1759-4790, DOI: 10.1038/nrrheum.2015.162 |
Nature Reviews Rheumatology 12/4 | 2020-02-26 |
2017 |
C. Manferdini, F. Paolella, E. Gabusi, L. Gambari, A. Piacentini, G. Filardo, S. Fleury-Cappellesso, A. Barbero, M. Murphy, G. Lisignoli Adipose stromal cells mediated switching of the pro-inflammatory profile of M1-like macrophages is facilitated by PGE2: in vitro evaluation published pages: 1161-1171, ISSN: 1063-4584, DOI: 10.1016/j.joca.2017.01.011 |
Osteoarthritis and Cartilage 25/7 | 2020-02-26 |
2016 |
Claire Bony, Mailys Cren, Sophie Domergue, Karine Toupet, Christian Jorgensen, Danièle Noël Adipose Mesenchymal Stem Cells Isolated after Manual or Water-jet-Assisted Liposuction Display Similar Properties published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2015.00655 |
Frontiers in Immunology 6 | 2020-02-26 |
2015 |
Y.-M. Pers, M. Ruiz, D. Noël, C. Jorgensen Mesenchymal stem cells for the management of inflammation in osteoarthritis: state of the art and perspectives published pages: 2027-2035, ISSN: 1063-4584, DOI: 10.1016/j.joca.2015.07.004 |
Osteoarthritis and Cartilage 23/11 | 2020-02-26 |
2016 |
Claire Bony, Mailys Cren, Sophie Domergue, Karine Toupet, Christian Jorgensen, Danièle Noël Adipose Mesenchymal Stem Cells Isolated after Manual or Water-jet-Assisted Liposuction Display Similar Properties published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2015.00655 |
Frontiers in Immunology 6 | 2020-02-26 |
2015 |
Maxime Ruiz, Stella Cosenza, Marie Maumus, Christian Jorgensen, Danièle Noël Therapeutic application of mesenchymal stem cells in osteoarthritis published pages: 33-42, ISSN: 1471-2598, DOI: 10.1517/14712598.2016.1093108 |
Expert Opinion on Biological Therapy 16/1 | 2020-02-26 |
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