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REDOXIT

Reactive oxygen species (ROS) as Elixirs against chronic Disease: OXidative regulatory mechanisms In T cells and neutrophils.

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

REDOXIT project word cloud

Explore the words cloud of the REDOXIT project. It provides you a very rough idea of what is the project "REDOXIT" about.

university uk chronic immune ros biochemical career industrial researcher biomarker animal area aston complementary partite uker mix balanced sle oxidation redox identification germany inflammation relevance proposing surrey tri erythematosus universitat cross groups uses models arthritis nox2 science exchange diseases ex modulate immunology collaborative human enzyme biology friedrich tomorrow systemic regulation vivo brings emergent expertise reactive modulators alexander leaders networking disease autoimmunity thiol ageing small extend molecule stimulate mediated interchange reaching cutting generate transfer drug vitro training health species academia population benefit ab edge cells candidate oxygen sweden skills basic lupus drugs redoxis innovative industry encourage anticipate

Project "REDOXIT" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITY OF SURREY Organization address address: Stag Hill city: GUILDFORD postcode: GU2 7XH website: www.surrey.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	https://www.surrey.ac.uk/redoxit
Total cost	144˙000 €
EC max contribution	144˙000 € (100%)
Programme	1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
Code Call	H2020-MSCA-RISE-2014
Funding Scheme	MSCA-RISE
Starting year	2015
Duration (year-month-day)	from 2015-07-01 to 2019-06-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITY OF SURREY UNIVERSITY OF SURREY Organization address address: Stag Hill city: GUILDFORD postcode: GU2 7XH website: www.surrey.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (GUILDFORD)	coordinator	40˙500.00
2	UNIVERSITATSKLINIKUM ERLANGEN UNIVERSITATSKLINIKUM ERLANGEN Organization address address: MAXIMILIANSPLATZ 2 city: ERLANGEN postcode: 91054 website: www.uk-erlangen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (ERLANGEN)	participant	58˙500.00
3	ASTON UNIVERSITY ASTON UNIVERSITY Organization address address: ASTON TRIANGLE city: BIRMINGHAM postcode: B4 7ET website: www.aston.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (BIRMINGHAM)	participant	31˙500.00
4	REDOXIS AB REDOXIS AB Organization address address: MEDICON VILLAGE SCHEELEVAGEN 2 city: LUND postcode: 223 81 website: http://www.redoxis.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (LUND)	participant	13˙500.00

Map

Project objective

We are proposing a four-year programme of knowledge transfer and networking between University of Surrey (SURREY, UK), Aston University (ASTON, UK), Friedrich-Alexander Universitat (UKER, Germany) and Redoxis AB (Redoxis, Sweden). The project targets an emerging area of biology, i.e. reactive oxygen species (ROS)-mediated regulation of immunology and ageing; it brings together the application of small molecule candidate drugs to generate ROS and uses innovative approaches to biomarker identification in models of chronic immune disease. This research has significant potential for application in human health and is of particular relevance to the ageing population. Training, knowledge transfer and skills exchange in this emergent area is important to extend the EU’s reach through cutting edge expertise. Interchange in this way will facilitate and promote early career researcher development into tomorrow’s research leaders. It will encourage new, cross-European collaboration between academia and industry. This tri-partite consortium brings together groups with very complementary expertise for knowledge exchange to benefit early career researchers: ASTON – in the biochemical analyses of ROS; SURREY in thiol oxidation and effects in vitro and ex vivo on and within immune cells relevant for biomarker development in chronic disease; UKER - in animal models of chronic diseases such as systemic lupus erythematosus (SLE) and arthritis; and Redoxis on development of novel drugs that stimulate production of ROS from the NOX2 enzyme as means to modulate chronic inflammation. The project objectives and challenges present a balanced mix between industrial application and basic science, with a focus on knowledge transfer and drug development. Through future collaborative funding, we anticipate far-reaching applications of redox modulators to manage chronic disease and increase the knowledge of both autoimmunity and ageing of the immune system.

Deliverables

List of deliverables.
Winter School on cell analysis	Other	2019-11-29 10:50:34
Summer School on advances in free radical research	Other	2019-11-29 10:50:34
Open workshop on inter-sectoral drug development	Other	2019-11-29 10:50:34

Take a look to the deliverables list in detail: detailed list of REDOXIT deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2018	Markus H. Hoffmann, Helen R. Griffiths The dual role of ROS in autoimmune and inflammatory diseases: Evidence from preclinical models published pages: , ISSN: 0891-5849, DOI: 10.1016/j.freeradbiomed.2018.03.016	Free Radical Biology and Medicine	2019-11-29
2018	Viktor Reshetnikov, Jonas Hahn, Christian MauerÃ¶der, Christine Czegley, Luis Enrique Munoz, Martin Herrmann, Markus H. Hoffmann, Andriy Mokhir Chemical Tools for Targeted Amplification of Reactive Oxygen Species in Neutrophils published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.01827	Frontiers in Immunology 9	2019-11-29
2017	Deborah KienhÃ¶fer, Jonas Hahn, Julia Stoof, Janka ZsÃ³fia Csepregi, Christiane Reinwald, Vilma Urbonaviciute, Caroline Johnsson, Christian MauerÃ¶der, Malgorzata J. Podolska, Mona H. Biermann, Moritz Leppkes, Thomas Harrer, Malin Hultqvist, Peter Olofsson, Luis E. Munoz, Attila Mocsai, Martin Herrmann, Georg Schett, Rikard Holmdahl, Markus H. Hoffmann Experimental lupus is aggravated in mouse strains with impaired induction of neutrophil extracellular traps published pages: e92920, ISSN: 2379-3708, DOI: 10.1172/jci.insight.92920	JCI Insight 2/10	2019-11-29

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The information about "REDOXIT" are provided by the European Opendata Portal: CORDIS opendata.