MITOsmORFs SIGNED
Identification and analysis of novel mitochondrial proteins encoded by small open reading frames
Total Cost €
0EC-Contrib. €
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Project "MITOsmORFs" data sheet
The following table provides information about the project.
| Coordinator |
UNIVERSITAETSKLINIKUM FREIBURG
Organization address contact info |
| Coordinator Country | Germany [DE] |
| Project website | http://www.biochemie.uni-freiburg.de/ag/wiedemann/ERC |
| Total cost | 2˙000˙000 € |
| EC max contribution | 2˙000˙000 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2014-CoG |
| Funding Scheme | ERC-COG |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-09-01 to 2020-08-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | UNIVERSITAETSKLINIKUM FREIBURG | DE (FREIBURG) | coordinator | 1˙094˙166.00 |
| 2 | ALBERT-LUDWIGS-UNIVERSITAET FREIBURG | DE (FREIBURG) | participant | 905˙833.00 |
Map
Project objective
Mitochondria are essential organelles with crucial roles in cellular energy metabolism, Fe-S cluster biogenesis, signaling and apoptosis. Mitochondrial dysfunction causes encephalomyopathy and neurodegenerative diseases. Mitochondria possess a remarkably high content of small proteins compared to other cellular compartments. About one third of the cellular proteins ≤15 kDa characterized to date are located in mitochondria. Functional examples of such small proteins cover the whole mitochondrial biology like cristae morphology, Fe-S cluster formation, metabolite transport, protein biogenesis and respiration. However, the intracellular localization and function of most small proteins is unknown. These small proteins constitute one third of the uncharacterized open reading frames and even three quarters of the dubious open reading frames in the model organism budding yeast. Taken together we predict that more than 10% of the mitochondrial proteome deserves to be discovered. In an initial study we demonstrated the mitochondrial localization of several uncharacterized small open reading frame (smORF) proteins. MITOsmORFs aims to identify over 100 novel small mitochondrial proteins. MITOsmORFs will determine the submitochondrial localization and the functional role of the novel mitochondrial proteins by genetic, proteomic, metabolomic and lipidomic analysis, including interaction mapping and characterization of mitochondrial activities in vivo and in organello to explore the unknown biology of smORF proteins localized to mitochondria.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Daqiang Pan, Nils Wiedemann, Bernd Kammerer Heat Stress-Induced Metabolic Remodeling in Saccharomyces cerevisiae published pages: 266, ISSN: 2218-1989, DOI: 10.3390/metabo9110266 |
Metabolites 9/11 | 2020-04-09 |
| 2020 |
Heike Rampelt, Iva Sucec, Beate Bersch, Patrick Horten, Inge Perschil, Jean-Claude Martinou, Martin van der Laan, Nils Wiedemann, Paul Schanda, Nikolaus Pfanner The mitochondrial carrier pathway transports non-canonical substrates with an odd number of transmembrane segments published pages: , ISSN: 1741-7007, DOI: 10.1186/s12915-019-0733-6 |
BMC Biology 18/1 | 2020-04-09 |
| 2017 |
Moritz Niemann, Anke Harsman, Jan Mani, Christian D. Peikert, Silke Oeljeklaus, Bettina Warscheid, Richard Wagner, André Schneider tRNAs and proteins use the same import channel for translocation across the mitochondrial outer membrane of trypanosomes published pages: E7679-E7687, ISSN: 0027-8424, DOI: 10.1073/pnas.1711430114 |
Proceedings of the National Academy of Sciences 114/37 | 2020-04-09 |
| 2017 |
Nataliia Naumenko, Marcel Morgenstern, Robert Rucktäschel, Bettina Warscheid, Peter Rehling INA complex liaises the F1Fo-ATP synthase membrane motor modules published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-01437-z |
Nature Communications 8/1 | 2020-04-09 |
| 2018 |
Lena Böttinger, Christoph U. Mårtensson, Jiyao Song, Nicole Zufall, Nils Wiedemann, Thomas Becker Respiratory chain supercomplexes associate with the cysteine desulfurase complex of the iron–sulfur cluster assembly machinery published pages: 776-785, ISSN: 1059-1524, DOI: 10.1091/mbc.E17-09-0555 |
Molecular Biology of the Cell 29/7 | 2020-04-09 |
| 2017 |
Vivien Krüger, Thomas Becker, Lars Becker, Malayko Montilla-Martinez, Lars Ellenrieder, F.-Nora Vögtle, Helmut E. Meyer, Michael T. Ryan, Nils Wiedemann, Bettina Warscheid, Nikolaus Pfanner, Richard Wagner, Chris Meisinger Identification of new channels by systematic analysis of the mitochondrial outer membrane published pages: 3485-3495, ISSN: 0021-9525, DOI: 10.1083/jcb.201706043 |
The Journal of Cell Biology 216/11 | 2020-04-09 |
| 2018 |
Daqiang Pan, Caroline Lindau, Simon Lagies, Nils Wiedemann, Bernd Kammerer Metabolic profiling of isolated mitochondria and cytoplasm reveals compartment-specific metabolic responses published pages: , ISSN: 1573-3882, DOI: 10.1007/s11306-018-1352-x |
Metabolomics 14/5 | 2020-04-09 |
| 2017 |
Marcel Morgenstern, Sebastian B. Stiller, Philipp Lübbert, Christian D. Peikert, Stefan Dannenmaier, Friedel Drepper, Uri Weill, Philipp Höß, Reinhild Feuerstein, Michael Gebert, Maria Bohnert, Martin van der Laan, Maya Schuldiner, Conny Schütze, Silke Oeljeklaus, Nikolaus Pfanner, Nils Wiedemann, Bettina Warscheid Definition of a High-Confidence Mitochondrial Proteome at Quantitative Scale published pages: 2836-2852, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2017.06.014 |
Cell Reports 19/13 | 2020-04-09 |
| 2018 |
Ulrike Topf, Ida Suppanz, Lukasz Samluk, Lidia Wrobel, Alexander Böser, Paulina Sakowska, Bettina Knapp, Martyna K. Pietrzyk, Agnieszka Chacinska, Bettina Warscheid Quantitative proteomics identifies redox switches for global translation modulation by mitochondrially produced reactive oxygen species published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-02694-8 |
Nature Communications 9/1 | 2020-04-09 |
| 2018 |
Isotta Lorenzi, Silke Oeljeklaus, Abhishek Aich, Christin Ronsör, Sylvie Callegari, Jan Dudek, Bettina Warscheid, Sven Dennerlein, Peter Rehling The mitochondrial TMEM177 associates with COX20 during COX2 biogenesis published pages: 323-333, ISSN: 0167-4889, DOI: 10.1016/j.bbamcr.2017.11.010 |
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1865/2 | 2020-04-09 |
| 2016 |
Nils Wiedemann, Nikolaus Pfanner Mitochondrial Machineries for Protein Import and Assembly published pages: , ISSN: 0066-4154, DOI: 10.1146/annurev-biochem-060815-014352 |
Annual Review of Biochemistry 86/1 | 2020-04-09 |
| 2016 |
Lars Ellenrieder, Åukasz OpaliÅ„ski, Lars Becker, Vivien Krüger, Oliver Mirus, Sebastian P. Straub, Katharina Ebell, Nadine Flinner, Sebastian B. Stiller, Bernard Guiard, Chris Meisinger, Nils Wiedemann, Enrico Schleiff, Richard Wagner, Nikolaus Pfanner, Thomas Becker Separating mitochondrial protein assembly and endoplasmic reticulum tethering by selective coupling of Mdm10 published pages: 13021, ISSN: 2041-1723, DOI: 10.1038/ncomms13021 |
Nature Communications 7 | 2020-04-09 |
| 2016 |
Sebastian B. Stiller, Jan Höpker, Silke Oeljeklaus, Conny Schütze, Sandra G. Schrempp, Jens Vent-Schmidt, Susanne E. Horvath, Ann E. Frazier, Natalia Gebert, Martin van der Laan, Maria Bohnert, Bettina Warscheid, Nikolaus Pfanner, Nils Wiedemann Mitochondrial OXA Translocase Plays a Major Role in Biogenesis of Inner-Membrane Proteins published pages: 901-908, ISSN: 1550-4131, DOI: 10.1016/j.cmet.2016.04.005 |
Cell Metabolism 23/5 | 2020-04-09 |
| 2016 |
Sebastian P. Straub, Sebastian B. Stiller, Nils Wiedemann, Nikolaus Pfanner Dynamic organization of the mitochondrial protein import machinery published pages: , ISSN: 1431-6730, DOI: 10.1515/hsz-2016-0145 |
Biological Chemistry 397/11 | 2020-04-09 |
| 2016 |
Ido Yofe, Uri Weill, Matthias Meurer, Silvia Chuartzman, Einat Zalckvar, Omer Goldman, Shifra Ben-Dor, Conny Schütze, Nils Wiedemann, Michael Knop, Anton Khmelinskii, Maya Schuldiner One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy published pages: 371-378, ISSN: 1548-7091, DOI: 10.1038/nmeth.3795 |
Nature Methods 13/4 | 2020-04-09 |
| 2018 |
Stefan Dannenmaier, Sebastian B. Stiller, Marcel Morgenstern, Philipp Lübbert, Silke Oeljeklaus, Nils Wiedemann, Bettina Warscheid Complete Native Stable Isotope Labeling by Amino Acids of Saccharomyces cerevisiae for Global Proteomic Analysis published pages: 10501-10509, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.8b02557 |
Analytical Chemistry 90/17 | 2020-04-09 |
| 2018 |
Katharina Weinhäupl, Caroline Lindau, Audrey Hessel, Yong Wang, Conny Schütze, Tobias Jores, Laura Melchionda, Birgit Schönfisch, Hubert Kalbacher, Beate Bersch, Doron Rapaport, Martha Brennich, Kresten Lindorff-Larsen, Nils Wiedemann, Paul Schanda Structural Basis of Membrane Protein Chaperoning through the Mitochondrial Intermembrane Space published pages: 1365-1379.e25, ISSN: 0092-8674, DOI: 10.1016/j.cell.2018.10.039 |
Cell 175/5 | 2020-04-09 |
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