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LIMB NETWORKS SIGNED

Network Analysis of Musculoskeletal Evolution and Modularity during the Fin-to-Limb Transition

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

LIMB NETWORKS project word cloud

Explore the words cloud of the LIMB NETWORKS project. It provides you a very rough idea of what is the project "LIMB NETWORKS" about.

vertebrates phylogenetic muscles quantify evolution training topological extant network forelimb species central evolutionary morphology techniques quantified land limb frontline imaging independent sophisticated semi globally context combination embodied not fossils anatomy hindlimb history vertebrate biology reconstruction models parts life anatomical data transition modules time acquired modular innovative fins multidisciplinary biodiversity morphologies question transformative fin fellow musculoskeletal candidate occurred unravel muscle forms adapting strength modularity autonomously limbs relations attachments morphological shaped facilitated extinct remarkable milestone integration theory theoretical revolutionize newly tools algorithms first gross graph researcher

Project "LIMB NETWORKS" data sheet

The following table provides information about the project.

Coordinator	THE ROYAL VETERINARY COLLEGE Organization address address: ROYAL COLLEGE STREET city: LONDON postcode: NW1 OTU website: www.rvc.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	https://osf.io/uqtf8/
Total cost	251˙857 €
EC max contribution	251˙857 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-GF
Starting year	2015
Duration (year-month-day)	from 2015-08-15 to 2018-08-14

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE ROYAL VETERINARY COLLEGE THE ROYAL VETERINARY COLLEGE Organization address address: ROYAL COLLEGE STREET city: LONDON postcode: NW1 OTU website: www.rvc.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	coordinator	251˙857.00
2	howard university howard university Organization address address: Howard University College of Medicine, 2400 Sixth Street, NW city: Washington postcode: 20059 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (Washington)	partner	0.00

Map

Project objective

The fin-to-limb transition was a major milestone in the history of life that shaped the morphology and remarkable biodiversity of land vertebrates. A central question in vertebrate evolution is how the various anatomical parts of limbs evolved semi-autonomously (modularity) while still growing and adapting in coordination (integration). The main goal of this project is to unravel (i) the evolutionary changes in modularity of the musculoskeletal system that occurred during the evolution from fins to limbs and (ii) how these newly acquired modular organizations facilitated the evolution of different morphologies for the forelimb and hindlimb. To this end, we will evaluate the modularity of limbs and the strength of topological integration among modules by using an innovative approach–anatomical network analysis–¬¬based on the topological relations that anatomical parts establish among them; these anatomical relations are embodied in network models and quantified globally using sophisticated algorithms from Graph Theory. We propose a multidisciplinary combination, for the first time, of (i) new data on fin/limb muscle anatomy in extant species, (ii) reconstruction of muscle attachments in extinct forms, and (iii) the use of innovative tools such as Anatomical Network Analysis to identify morphological modules and quantify their integration within a phylogenetic context. The results of this unique and transformative project have the potential to revolutionize our understanding of limb evolution during the fin-limb transition. The training in gross anatomy, imaging techniques, and reconstruction of muscles in fossils by the leading researchers involved in this project will foster the development of the candidate Fellow as an independent and innovative frontline researcher in theoretical, evolutionary, and comparative biology in the EU.

Publications

List of publications.
year	authors and title	journal	last update
2018	Diego Rasskin-Gutman, Borja Esteve-Altava Concept of Burden in Evo-Devo published pages: 1-11, ISSN: , DOI: 10.1007/978-3-319-33038-9_48-1	Evolutionary Developmental Biology	2019-06-12
2018	Borja Esteve-Altava, Diego Rasskin-Gutman Anatomical network analysis in Evo-Devo published pages: 1-19, ISSN: , DOI: 10.1007/978-3-319-33038-9_57-1	Evolutionary Developmental Biology	2019-06-12
2017	Borja Esteve-Altava Challenges in identifying and interpreting organizational modules in morphology published pages: , ISSN: 0362-2525, DOI: 10.1002/jmor.20690	Journal of Morphology	2019-06-12
2018	Rui Diogo, Julia L. Molnar, Campbell Rolian, Borja Esteve-Altava First anatomical network analysis of fore- and hindlimb musculoskeletal modularity in bonobos, common chimpanzees, and humans published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-25262-6	Scientific Reports 8/1	2019-06-12
2016	Rui Diogo, Peter Johnston, Julia L. Molnar, Borja Esteve-Altava Characteristic tetrapod musculoskeletal limb phenotype emerged more than 400 MYA in basal lobe-finned fishes published pages: 37592, ISSN: 2045-2322, DOI: 10.1038/srep37592	Scientific Reports 6	2019-06-12
2016	Borja Esteve-Altava In search of morphological modules: a systematic review published pages: , ISSN: 1464-7931, DOI: 10.1111/brv.12284	Biological Reviews	2019-06-12
2018	Borja Esteve-Altava, Julia L. Molnar, Peter Johnston, John R. Hutchinson, Rui Diogo Anatomical network analysis of the musculoskeletal system reveals integration loss and parcellation boost during the fins-to-limbs transition published pages: 601-618, ISSN: 0014-3820, DOI: 10.1111/evo.13430	Evolution 72/3	2019-06-12
2018	Borja Esteve-Altava, Stephanie E Pierce, Julia L Molnar, Peter Johnston, Rui Diogo, John R Hutchinson Evolutionary parallelisms of pectoral and pelvic network-anatomy from fins to limbs published pages: , ISSN: , DOI: 10.1101/374504	bioRxiv 374504	2019-06-12

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