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ReprObesity SIGNED

Overweight-induced Hypogonadism as major factor for the generation and/or perpetuation of Metabolic Co-morbidities of Obesity: Contribution of Epigenetic Regulatory Mechanisms

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

ReprObesity project word cloud

Explore the words cloud of the ReprObesity project. It provides you a very rough idea of what is the project "ReprObesity" about.

time preclinical sexual relevance medical aid neurons steroids co perturbed molecular gated models epigenetic health suggests pathophysiological disorder homeostasis frequently obesity perturbations underlying generation elucidate alterations nkb metabolic linked phenomenon prevalence vicious axes hypogonadism expression contribution influence experimental likewise tools stage unknown involvement circle kiss1 substantially epigenetics lifestyle hormonal modifications stress reproductive treatment metabolically serious deregulation morbidities puberty context regulatory maintenance suggested responsible gonadal setting complications course overweight global perpetuation hypothalamic mechanisms

Project "ReprObesity" data sheet

The following table provides information about the project.

Coordinator	UNIVERSIDAD DE CORDOBA Organization address address: AVENIDA DE MEDINA AZAHARA 5 city: CORDOBA postcode: 14005 website: www.uco.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Total cost	158˙121 €
EC max contribution	158˙121 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-EF-RI
Starting year	2016
Duration (year-month-day)	from 2016-10-01 to 2018-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSIDAD DE CORDOBA UNIVERSIDAD DE CORDOBA Organization address address: AVENIDA DE MEDINA AZAHARA 5 city: CORDOBA postcode: 14005 website: www.uco.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (CORDOBA)	coordinator	158˙121.00

Map

Project objective

Obesity is a global health problem whose prevalence is increasing substantially due to lifestyle changes. This complex medical condition is frequently linked to serious metabolic complications and deregulation of hormonal axes, which lead to perturbed homeostasis in conditions of overweight. Different studies have suggested that obesity is often associated to hypogonadism, a reproductive disorder that might also promote metabolic alterations, thus setting a vicious circle in the generation/perpetuation of obesity co-morbidities. While the targets and molecular mechanisms underlying this phenomenon are still unknown, emerging evidence from experimental models of metabolic stress linked to hypogonadism strongly suggests the potential role of perturbations of hypothalamic Kiss1/NKB neurons. Likewise, the recently identified involvement of epigenetics in the control of Kiss1 expression at puberty, a crucial stage in sexual development that is metabolically gated, suggests also the contribution of these regulatory mechanisms to this phenomenon. In this context, this project aims to elucidate the pathophysiological relevance of epigenetic regulatory mechanisms in obesity-induced hypogonadism and their influence in the generation/ maintenance of the metabolic complications of overweight. To this end, we will characterize the time-course of alterations of key hormonal and epigenetic factors in preclinical models of obesity and will evaluate the contribution of epigenetic modifications in deregulation of hypothalamic Kiss1/NKB neurons in conditions of overweight. In addition, we will analyse the potential role of gonadal steroids in this phenomenon. This project will help to identify the molecular targets and epigenetic mechanisms responsible for the metabolic perturbations linked to obesity-induced hypogonadism, and will aid to define better tools for the treatment of these complications.

Publications

List of publications.
year	authors and title	journal	last update
2018	M. J. Vazquez, C. A. Toro, J. M. Castellano, F. Ruiz-Pino, J. Roa, D. Beiroa, V. Heras, I. Velasco, C. Dieguez, L. Pinilla, F. Gaytan, R. Nogueiras, M. A. Bosch, O. K. RÃ¸nnekleiv, A. Lomniczi, S. R. Ojeda, M. Tena-Sempere SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-06459-9	Nature Communications 9/1	2019-04-18

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