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fetISC SIGNED

Characterizing drivers of intestinal tissue maturation in vitro and in vivo

Total Cost €

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EC-Contrib. €

0

Partnership

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 fetISC project word cloud

Explore the words cloud of the fetISC project. It provides you a very rough idea of what is the project "fetISC" about.

profiling    counterpart    sources    isc    suitability    govern    progression    adult    decipher    mature    transferability    secretory    intestinal    mapping    generate    intestines    techniques    teratoma    overexpressed    murine    exposure    calf    vitro    immature    trigger    stage    precise    developmental    platform    impede    differentiated    cell    fetal    differentiation    incubators    lineages    cells    epithelium    specified    acquire    differentially    expressed    intestine    notably    clinics    pluripotent    stem    purposes    hypothesize    tracing    mice    regenerative    transplantation    host    location    expression    instrumental    protocols    direct    initiated    models    responsible    fine    either    serum    combine    constitute    gene    one    endodermal    maturation    disease    therapies    tissue    molecular    modulation    hipsc    iscs    driving    structures    medicine    laboratory    human    transcription    physiological    origin    neonatal    culture    absence    elucidated    mechanisms   

Project "fetISC" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Project website https://www.bric.ku.dk/Research/jensen_group/
 Total cost 212˙194 €
 EC max contribution 212˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-02-01   to  2018-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 212˙194.00

Map

 Project objective

One of the challenges in regenerative medicine is to generate adult intestinal stem cells (ISCs) from human induced pluripotent stem cells (hiPSC) in vitro in defined conditions. This will be important in order to establish intestinal cell transplantation therapies and a platform for neonatal disease modelling. These issues constitute the main goal of the proposal. The current protocols to direct intestinal differentiation from hiPSC impede their suitability for human transplantation purposes either because they require mice as tissue culture incubators (teratoma formation), long exposure to calf serum, or generate cells with fetal properties. The immature fetal intestine is distinct from its mature counterpart most notably by its absence of differentiated secretory lineages. Moreover the precise location and developmental stage from which ISCs are specified in fetal intestine as well as the mechanisms that govern the progression towards an adult epithelium remain to be elucidated. In order to generate adult ISCs from pluripotent sources it is instrumental to decipher the molecular mechanisms driving ISC maturation under physiological conditions. The project will be initiated with the fine mapping of ISC origin in the fetal epithelium using cell tracing techniques. Then I will characterize how fetal ISCs acquire adult properties at the molecular level. In the host laboratory we hypothesize that differentially expressed transcription factors are responsible for the unique characteristics of fetal and adult ISCs. Recently, using gene expression profiling comparing fetal and adult intestinal cells I have identified specific endodermal transcription factors overexpressed in the immature structures. I expect through the modulation of such factors to trigger the intestinal maturation. To ensure the transferability of the results into clinics I will combine studies with murine models and cells from human fetal and adult intestines.

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