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LQTS-HORSES

Platform for diagnosing long QT syndrome in horses - Step II: Identification of long QT syndrome

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

LQTS-HORSES project word cloud

Explore the words cloud of the LQTS-HORSES project. It provides you a very rough idea of what is the project "LQTS-HORSES" about.

model equine university gated cardiac pool rhythm horses copenhagen backgrounds syndrome screen triple exclude mechanism voltage sequencing negative performance disturbance diagnostic sport men arrhythmias death racing performed tools channels perception electrophysiologically qt sudden causes repolarisation platform safety genetic potassium reduce diagnosing describe welfare economic trained similitudes clamp regard group screening public samples population sports pathophysiological ecgs ventricular form sequences severe lqts events generating function insights animal polymorphisms athletes disturbances occurring pathophysiology benefit blood identification valuable deaths industry mutations techniques delayed

Project "LQTS-HORSES" data sheet

The following table provides information about the project.

Coordinator	KOBENHAVNS UNIVERSITET Organization address address: NORREGADE 10 city: KOBENHAVN postcode: 1165 website: www.ku.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Denmark [DK]
Project website	http://ecg.ku.dk/
Total cost	200˙194 €
EC max contribution	200˙194 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-EF-ST
Starting year	2015
Duration (year-month-day)	from 2015-10-01 to 2017-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	KOBENHAVNS UNIVERSITET KOBENHAVNS UNIVERSITET Organization address address: NORREGADE 10 city: KOBENHAVN postcode: 1165 website: www.ku.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KOBENHAVN)	coordinator	200˙194.00

Map

Project objective

The Equine Cardiac Group at the University of Copenhagen has established a platform for diagnosing long QT syndrome (LQTS) in horses. In men, this condition is a cause of severe ventricular arrhythmias leading to death in some cases. The pathophysiological mechanism behind this disturbance of the cardiac rhythm is a delayed repolarisation often associated with reduced function of voltage gated potassium (K-) channels. LQTS is one of the cardiac causes of sudden death in athletes. Sudden deaths occurring during public events have a highly negative impact on the public perception about high performance sports, both in men and in horses, and raise concerns about animal welfare especially in the racing industry. With the new tools developed by the Equine Cardiac Group the presence of LQTS will be investigated in horses by screening ECGs from a large pool of horses with different genetic backgrounds. Genetic sequencing will be performed on blood samples from this population and from horses with sudden death to describe genetic polymorphisms or mutations in the K-channels. The identified equine sequences will be compared to those described for men and the function of the identified mutations will be characterized electrophysiologically using voltage-clamp techniques, generating then new insights into the pathophysiology of LQTS in horses. The benefit of the proposed project will be triple: 1) It will allow for identification of LQTS in horses and will aim at developing a reliable diagnostic test to screen horses for LQTS; 2) It will enable us to exclude them form racing and to reduce sudden deaths during sport events and therefore it will increase safety and animal welfare in racing industry, an important economic factor for many European areas; 3) Similitudes between men and horses in regard to the pathophysiology of LQTS might establish horses as a valuable model for investigating disturbances of repolarisation, especially those occurring in highly trained athletes.

Publications

List of publications.
year	authors and title	journal	last update
2017	Philip J. Pedersen, Kirsten B. Thomsen, Jon B. Flak, Maria A. Tejada, Frank Hauser, Dagmar Trachsel, Rikke Buhl, Theodore Kalbfleisch, Michael Scott DePriest, James N. MacLeod, Kirstine Calloe, Dan A. Klaerke Molecular cloning and functional expression of the K + channel K V 7.1 and the regulatory subunit KCNE1 from equine myocardium published pages: 79-86, ISSN: 0034-5288, DOI: 10.1016/j.rvsc.2017.09.010	Research in Veterinary Science 113	2019-07-23
2016	P.J. Pedersen, M. Karlsson, M. FlethÃ¸j, D.S. Trachsel, J.K. Kanters, D.A. Klaerke, R. Buhl Differences in the electrocardiographic QT interval of various breeds of athletic horses during rest and exercise published pages: 255-264, ISSN: 1760-2734, DOI: 10.1016/j.jvc.2016.02.002	Journal of Veterinary Cardiology 18/3	2019-07-23

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The information about "LQTS-HORSES" are provided by the European Opendata Portal: CORDIS opendata.