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ICSIS

The interaction and clearance of senescent vascular cells by the innate immune system

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

ICSIS project word cloud

Explore the words cloud of the ICSIS project. It provides you a very rough idea of what is the project "ICSIS" about.

tissue cardiovascular city sectorial significantly founded drugs erasmus mechanisms age disciplinary molecular disease cardiology vivo life transferable plays contributes molecule intersectorial physiology therapeutic coordinated ageing scientific impacted paradoxical clinical eliminating cell delineate cross sectors small collaborations centred efficacy leader organisms nl drug talented complementary redoxis fibrotic cellular later uk protects vascular exceptionally clearance techniques fellow sites aston purpose metabolism interaction accumulate biology deepen senescent predominantly vitro hospital hosts strategies context models function cells cancer immune explore sb skills training pathologies swe innate understand ten senescence immunity ex

Project "ICSIS" data sheet

The following table provides information about the project.

Coordinator	ASTON UNIVERSITY Organization address address: ASTON TRIANGLE city: BIRMINGHAM postcode: B4 7ET website: www.aston.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	https://www.researchgate.net/project/The-interaction-and-clearance-of-senescent-vascular-cells-by-the-innate-immune-system
Total cost	183˙454 €
EC max contribution	183˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-EF-ST
Starting year	2015
Duration (year-month-day)	from 2015-06-01 to 2017-05-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	ASTON UNIVERSITY ASTON UNIVERSITY Organization address address: ASTON TRIANGLE city: BIRMINGHAM postcode: B4 7ET website: www.aston.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (BIRMINGHAM)	coordinator	183˙454.00

Map

Project objective

Cell senescence plays a paradoxical but important role in physiology; it protects organisms against cancer but also contributes to age-related loss of tissue function. Senescent cells accumulate during ageing, particularly at sites of age-related pathologies such as vascular tissue, contributing to fibrotic cardiovascular disease , . Therefore, the aim of this research is to understand why senescent cells accumulate later in life for the purpose of identifying potential therapeutic strategies for eliminating senescent cells. This project, founded in an emerging field of ageing research, will determine the interaction and clearance of senescent cells by ageing innate immune cells. Using in vitro, ex vivo and in vivo approaches the fellow will delineate the mechanisms of interaction between senescent vascular cells and the innate immune system and how they are impacted by age. This will significantly advance knowledge and lead to novel molecular targets to explore for eliminating age-associated vascular senescent cells. Since the field of cellular senescence is predominantly centred within molecular cell biology and cancer, this coordinated cross-disciplinary and cross-sectorial approach will provide novel insight into vascular senescence. Through an ambitious research training programme, the fellow will develop scientific, complementary and transferable skills in metabolism, innate immunity and vascular function in age-related disease from Aston, UK with intersectorial training to develop small molecule drugs from Redoxis SB, SWE; evaluate drug efficacy in models of ageing (Erasmus, NL); in the context of clinical cardiology (Aston/City Hospital, UK). It will deepen collaborations for partners, provide new techniques to the hosts and enhance the skills of exceptionally talented research fellow, with over ten years’ experience in the field of cellular senescence, forward as a research leader with experience of working effectively across sectors.

Publications

List of publications.
year	authors and title	journal	last update
2017	O. S. Ademowo, H. K. I. Dias, D. G. A. Burton, H. R. Griffiths Lipid (per) oxidation in mitochondria: an emerging target in the ageing process? published pages: , ISSN: 1389-5729, DOI: 10.1007/s10522-017-9710-z	Biogerontology	2019-06-13

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The information about "ICSIS" are provided by the European Opendata Portal: CORDIS opendata.