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CoordinGrowthDev

Characterization of the mechanism of inter-organ communication coordinating tissue growth and developmental timing

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

CoordinGrowthDev project word cloud

Explore the words cloud of the CoordinGrowthDev project. It provides you a very rough idea of what is the project "CoordinGrowthDev" about.

nature signaling fitness setting conduct tissues characterization genetic skills molecular period progression adult transition block combined regulation tissue laboratory coupling survival appropriate biased couple screen scientific traits steroid exist light functions transitions biology expertise proportions ensures gain hormone discovered experimental stumbled size parts career possibility fruit newly organisms over adults frame characterizing successful peptide synchronized developmental signals timing mediating flies emergence proper inter peptides until allowed life unraveling insulin first feedback biological conceptual coordinates unravel started drosophila organ shed body me organs mechanisms receptor host species communication roles vertebrates dilp8

Project "CoordinGrowthDev" data sheet

The following table provides information about the project.

Coordinator	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Organization address address: RUE MICHEL ANGE 3 city: PARIS postcode: 75794 website: www.cnrs.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Project website	https://science.institut-curie.org/research/biology-cancer-genetics-and-epigenetics/developmental-biology-and-genetics/genetics-and-physiology-of-growth/
Total cost	173˙076 €
EC max contribution	173˙076 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-EF-ST
Starting year	2016
Duration (year-month-day)	from 2016-03-01 to 2018-06-20

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Organization address address: RUE MICHEL ANGE 3 city: PARIS postcode: 75794 website: www.cnrs.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	coordinator	173˙076.00

Map

Project objective

Over the recent years, research in developmental biology has stumbled upon the problem of how development ensures that organisms achieve appropriate body and organ size. The coordination of organ growth with the developmental program is essential for the emergence of adults with proper body size and proportions. These species-specific features condition many traits of adult life such as fitness and survival. Studies on fruit flies have allowed setting up the conceptual frame for this research. Our current understanding is that tissue growth and the developmental program are synchronized by feedback control mechanisms that block the transition to the next developmental period until all tissues have completed growth.

Recent work in Drosophila has started unraveling the nature of the signals that couple tissue growth with developmental progression. A newly discovered Drosophila insulin-like peptide called Dilp8 is key in this coupling, raising the possibility that peptides with similar roles may exist in vertebrates. The current project aims at characterizing the molecular mechanisms by which Dilp8 coordinates development of the different body parts. First, I will conduct a biased genetic screen to identify the receptor for Dilp8. This will allow a better characterization of the biological functions of Dilp8. On one hand, I will unravel the target tissues of Dilp8 mediating regulation of steroid hormone and developmental transitions. On the other hand, I will investigate the role of Dilp8 signaling in coordinating growth among developing organs.

The project will shed light on the mechanisms of inter-organ communication that ensure the coordination of growth between tissues and with the developmental timing. The expertise of the host laboratory, combined the conceptual frame and experimental approaches of the project, will allow me to gain new skills and scientific knowledge, and to develop a successful research career in the field of growth control.

Publications

List of publications.
year	authors and title	journal	last update
2015	Julien Colombani, DitteÂ S. Andersen, Laura Boulan, Emilie Boone, Nuria Romero, Virginie Virolle, Michael Texada, Pierre LÃ©opold Drosophila Lgr3 Couples Organ Growth with Maturation and Ensures Developmental Stability published pages: 2723-2729, ISSN: 0960-9822, DOI: 10.1016/j.cub.2015.09.020	Current Biology 25/20	2019-06-13
2017	Emilie Boone, Laura Boulan, Ditte S. Andersen, Nuria Romero, Pierre LÃ©opold, Julien Colombani Des insulines pour orchestrer laÂ croissance published pages: 637-641, ISSN: 0767-0974, DOI: 10.1051/medsci/20173306021	mÃ©decine/sciences 33/6â€“7	2019-06-13

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The information about "COORDINGROWTHDEV" are provided by the European Opendata Portal: CORDIS opendata.