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BBFGEN

Genetic analysis of rare and common variation in a large Brazilian bipolar family

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

BBFGEN project word cloud

Explore the words cloud of the BBFGEN project. It provides you a very rough idea of what is the project "BBFGEN" about.

act variants disorders will mood genome prevention bp psychiatric periods effect accounting elevated loci heritability 37 underpinnings self resource score pleasure utilizing provides enjoyable profiles assortative 75 utility individual context describes esteem persistent featuring picture treatment depression size bipolar shed something architecture genetic mating pervasive diminishing estimates variation disease me brazilian light individuals family mdd incorporate model incidence powerful mapping burden aiding rare generations bbf predictive individually risk contributors multigenerational broad marriages normally genes offers depressive onset pathology disorder unclear uniquely understand global consisting polygenic whereby age association utilize

Project "BBFGEN" data sheet

The following table provides information about the project.

Coordinator	KING'S COLLEGE LONDON Organization address address: STRAND city: LONDON postcode: WC2R 2LS website: www.kcl.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	https://www.kcl.ac.uk/ioppn/depts/mrc/index.aspx
Total cost	183˙454 €
EC max contribution	183˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-EF-ST
Starting year	2015
Duration (year-month-day)	from 2015-05-01 to 2017-04-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	KING'S COLLEGE LONDON KING'S COLLEGE LONDON Organization address address: STRAND city: LONDON postcode: WC2R 2LS website: www.kcl.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	coordinator	183˙454.00

Map

Project objective

This proposal describes my aim to use a uniquely large multigenerational family to better understand the genetic underpinnings of mood disorders: the Brazilian Bipolar Family (BBF). The family has a high incidence of mood disorders, featuring diminishing age of onset over generations and assortative mating, whereby many of the marriages in the family are between individuals with a psychiatric disorder. Mood disorders are leading contributors to the global burden of disease. Bipolar disorder is characterized by periods of elevated mood and periods of depression. Major depressive disorder is characterized by pervasive and persistent low mood, low self-esteem and loss of interest or pleasure in normally enjoyable activities. Heritability estimates are 37% for MDD and up to 75% for BP. The current picture for complex disorders is of a genetic architecture consisting of both common and rare variants contributing risk. Genetic studies of mood disorders have not yet individual variants/genes accounting for a large increase in risk. The effect of common variants in the family context is unclear. I propose to utilize the BBF as a unique resource for studying both common and rare variation in mood disorders. Its size offers a powerful means for mapping genetic loci for mood disorders that are individually rare but common within the family. It also provides us with a unique model in which to analyse individual genetic risk profiles, utilizing the large sample size of and predictive ability of previous case-control association studies for each family member into a polygenic risk score. This will also allow me to assess assortative mating, which may act to increase polygenic risk to mood disorders over generations. I will develop an approach which will allow me to incorporate genome-wide case-control study results into family studies – something with broad utility for the field. My study will shed light on the genetic pathology of mood disorders, aiding prevention and treatment.

Publications

List of publications.
year	authors and title	journal	last update
2017	Danai Dima; Gerome Breen; Sophia Frangou; Simone de Jong The polygenic risk for bipolar disorder influences brain regional function relating to visual and default state processing of emotional information published pages: , ISSN: 2213-1582, DOI: 10.1016/j.nicl.2016.10.022	Neuroimage: Clinical 1	2019-06-14
2017	Mateus Jose Abdalla Diniz, Andiara Calado Saloma Rodrigues, View ORCID ProfileAry Gadelha, Shaza Alsabban, Camila Guindalini, Jose Paya-Cano, View ORCID ProfileSimone de Jong, View ORCID ProfilePeter McGuffin, View ORCID ProfileRodrigo Affonseca Bressan, View ORCID ProfileGerome Breen Whole genome linkage analysis in a large Brazilian multigenerational family reveals distinct linkage signals for Bipolar Disorder and Depression. published pages: , ISSN: , DOI: 10.1101/106260	bioRxiv - the preprint server for biology	2019-06-14
2017	Simone de Jong, Mateus Jose Abdalla Diniz, Andiara C Saloma Rodrigues, Ary Gadelha, Marcos L Santoro, Vanessa K Ota, Cristiano Noto, MDD & BIP groups of Psychiatric Genomics Consortiu, Charles Curtis, Hamel Patel, Lynsey S Hall, Paul F O\'Reilly, Sintia I Belangero, Rodrigo Bressan, Gerome Breen Applying polygenic risk scoring for psychiatric disorders within a family context published pages: , ISSN: , DOI: 10.1101/103713	bioRxiv - the preprint server for biology	2019-06-14

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The information about "BBFGEN" are provided by the European Opendata Portal: CORDIS opendata.