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OSS SIGNED

Spatio-temporal control of the Src kinase activation through Optogenetics in Cell invasion

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

OSS project word cloud

Explore the words cloud of the OSS project. It provides you a very rough idea of what is the project "OSS" about.

activation powerful hosts dynamically expertise acting multifarious pleiotropic biological intensities first migration induce cross networks temporal space biosensors contractility spatio tyrosine actively adhesive biotechnology pleiotropicity signal equilibrium actions globally invasion kinase area independently dynamic structures create cell oss questions regulation road acto live theory basis innovative correlate environmental adhesion dependent explore manipulate off biology function poorly cellular coordinates induction dynamics invadosome invadosomes hypothesis signaling signals ultimate encoded fundamental optogenetics patterns organization outputs inputs secondly time mimic src cells observe

Project "OSS" data sheet

The following table provides information about the project.

Coordinator	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Organization address address: RUE MICHEL ANGE 3 city: PARIS postcode: 75794 website: www.cnrs.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Project website	https://www.facebook.com/OSS-project-158060481556584/
Total cost	185˙076 €
EC max contribution	185˙076 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-EF-ST
Starting year	2016
Duration (year-month-day)	from 2016-03-01 to 2018-02-28

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Organization address address: RUE MICHEL ANGE 3 city: PARIS postcode: 75794 website: www.cnrs.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	coordinator	185˙076.00

Map

Project objective

Cell signaling is a complex system that coordinates cell actions in response to environmental inputs. Signaling pathways are often seen and investigated as on/off networks, but the reality of the intensities and spatio-temporal organization of these networks has been poorly integrated with the dynamics of cellular outputs in response to specific environmental inputs. In the OSS project we aim to approach this general problem by focusing on a specific cellular function, cell invasion (the hosts area of expertise). We propose to 1) use the formation of invadosomes, characteristic acto-adhesive structures important for cell invasion as a specific cellular function, to address these fundamental questions 2) and target the pleiotropic tyrosine kinase Src that has the ability to induce cell invasion globally by acting on cell adhesion, migration, contractility and invadosome dynamics independently of any environmental regulation, to investigate how a biological signal can be dynamically encoded into specific multifarious cellular outputs. Our hypothesis is that specific spatio-temporal patterns of Src activation could be the basis of its pleiotropicity. Thus, the first step of the OSS project will be to use Src biosensors to observe different patterns of Src activation and correlate them with the dynamics of Src-dependent cellular outputs (such as induction of invadosomes). Secondly, we will directly control spatio-temporal Src activity in live cells using optogenetics, a powerful and innovative approach that will allow us to mimic the observed patterns of Src activation and to create new patterns in order to explore dynamic equilibrium between Src signaling and its specific cellular outputs. This project is at the cross-road of signaling theory in biology, cell biology of acto-adhesive structures and biotechnology fields. The goal of the OSS project is to actively manipulate signals in space and time with the ultimate aim to control dynamic process of cell invasion.

Publications

List of publications.
year	authors and title	journal	last update
2018	Carlos Pardo-Pastor, Fanny Rubio-Moscardo, Marina Vogel-GonzÃ¡lez, Selma A. Serra, Alexandros Afthinos, Sanela Mrkonjic, Olivier Destaing, Juan F. Abenza, JosÃ© M. FernÃ¡ndez-FernÃ¡ndez, Xavier Trepat, Corinne Albiges-Rizo, Konstantinos Konstantopoulos, Miguel A. Valverde Piezo2 channel regulates RhoA and actin cytoskeleton to promote cell mechanobiological responses published pages: 1925-1930, ISSN: 0027-8424, DOI: 10.1073/pnas.1718177115	Proceedings of the National Academy of Sciences 115/8	2019-06-14
2017	Sanela Mrkonjic, Olivier Destaing, Corinne Albiges-Rizo Mechanotransduction pulls the strings of matrix degradation at invadosome published pages: 190-203, ISSN: 0945-053X, DOI: 10.1016/j.matbio.2016.06.007	Matrix Biology 57-58	2019-06-14

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