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PIOMES

Pbx proteins as pioneer factors promoting signal specificity in mesodermal differentiation

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 PIOMES project word cloud

Explore the words cloud of the PIOMES project. It provides you a very rough idea of what is the project "PIOMES" about.

skeletal    diseases    cellular    embryos    immunoprecipitation    embryonic    promotes    postdoctoral    transcription    genetic    stem    embryo    routinely    mastered    strength    training    strategies    healthy    signalling    insights    treating    rational    life    differentiation    degenerative    progenitors    chromatin    had    extensively    combines    expressed    danstem    somitic    streak    recruitment    acquisition    opening    landscape    murine    ultimately    organisms    fate    shape    converting    critical    primitive    tf    efficiency    ways    specified    pools    date    central    epiblast    mesoderm    question    cells    purpose    assays    transcriptional    proteins    pbx    analogous    competence    human    region    vitro    types    regenerative    pioneer    mouse    cell    mps    tools    regulation    conceive    limited    muscle    combat    specify    bone    binding    wnt    dynamics    arise    blood    hescs    lineage    specification    tfs    muscular    mesodermal    esc    dystrophies    muscles   

Project "PIOMES" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Project website http://danstem.ku.dk/research1/ferretti-lab/
 Total cost 200˙194 €
 EC max contribution 200˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2017-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 200˙194.00

Map

 Project objective

The development of healthy organisms requires the formation of different cellular systems, such as a blood, bone and muscle. All these different cell types arise during embryonic life from specific pools of mesodermal progenitors (MPs). A central question is how distinct MPs are specified and ultimately why different cells respond to signalling pathways in different ways? Critical insights here are directly relevant to conceive strategies for increasing the efficiency of mesodermal differentiation aimed for treating muscular degenerative diseases. To date, in vitro, somitic mesoderm differentiation for regenerative purpose has had limited success. Wnt signalling promotes Embryonic Stem Cell (ESC) differentiation of all the MPs, including skeletal muscles. The activity of specific pioneer transcription factors (TFs) may be the key for converting Wnt signalling pathways into a specific transcriptional program. Pioneer TFs shape the chromatin landscape by opening the chromatin and allowing the recruitment of lineage specific TFs, and thus ultimately control the TF binding dynamics and the acquisition of a specific cell fate. Pbx proteins are pioneer TFs, which are specifically expressed in the primitive streak, the region of the embryo that will produce all mesoderm, and are critical for promoting mesodermal specification. Here, I will establish how Pbx proteins specify MPs and determine the competence of early mesoderm to respond to Wnt signalling. To this end, I will use mouse embryos and murine epiblast stem cells, which are analogous to human ESC (hESCs). My approach combines the strength of an in vitro ESC differentiation method, routinely used at DanStem, with chromatin immunoprecipitation and transcriptional regulation assays, which I have extensively mastered during my postdoctoral training. I expect that my findings will provide novel tools for rational design of strategies to combat genetic and degenerative muscular diseases, such as muscular dystrophies.

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The information about "PIOMES" are provided by the European Opendata Portal: CORDIS opendata.

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